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79 条记录 (耗时 0.012 秒)

    Hyperforin derivatives, use thereof and formulations containing them
    11.
    发明授权
    Hyperforin derivatives, use thereof and formulations containing them 有权
    Hyperforin衍生物，其使用和含有它们的制剂

    公开(公告)号：US06656510B2

    公开(公告)日：2003-12-02

    申请号：US09730536

    申请日：2000-12-07

    申请人： Ezio Bombardelli ,  Paolo Morazzoni

    发明人： Ezio Bombardelli ,  Paolo Morazzoni

    IPC分类号： A61K3578

    CPC分类号： A61K31/122 ,  C07C69/013 ,  C07C69/734 ,  C07C69/92

    摘要： The invention relates to compounds of the formula: in which R is a saturated or unsaturated, straight or branched, C1-C22 acyl group, optionally having one or more substituents, which can be the same or different, selected from halogen atoms, nitro, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, C1-C6-acylamino groups; a cycloaliphatic or aromatic acyl residue in which the aromatic moiety optionally has one or more substituents, which can be the same or different, selected from halogen atoms, hydroxy, methoxy, amino groups; a glycidic residue in which one or more hydroxy groups are optionally alkylated or acylated. The invention further relates to methods for extracting and extracts of these compounds from Hypericum perforatum as well as their use as active ingredients in antidepression medication.

    摘要翻译： 本发明涉及下式的化合物：其中R是饱和或不饱和的直链或支链C 1 -C 22酰基，任选具有一个或多个可以相同或不同的取代基，可以选自卤素原子，硝基， 氨基，C 1 -C 6烷基氨基，二-C 1 -C 6烷基氨基，C 1 -C 6酰基氨基; 芳族部分任选具有一个或多个选自卤素原子，羟基，甲氧基，氨基中的相同或不同的取代基的脂环族或芳族酰基残基; 其中一个或多个羟基任选被烷基化或酰化的缩水甘油基残基。 本发明还涉及从贯叶连翘提取和提取这些化合物的方法以及它们作为抗抑郁药物中的活性成分的用途。

    Pharmaceutical compositions containing flavanolignanes and methods for using same as an antiproliferative
    13.
    发明授权
    Pharmaceutical compositions containing flavanolignanes and methods for using same as an antiproliferative 失效
    含有黄烷醇烷的药物组合物及其用作抗增生剂的方法

    公开(公告)号：US5912265A

    公开(公告)日：1999-06-15

    申请号：US952415

    申请日：1997-11-18

    申请人： Ezio Bombardelli ,  Paolo Morazzoni

    发明人： Ezio Bombardelli ,  Paolo Morazzoni

    IPC分类号： A61K36/00 ,  C07D407/04 ,  A61K31/335 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/366 ,  A61K31/683 ,  A61K36/28 ,  A61K36/48 ,  A61K47/24 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00

    CPC分类号： A61K31/357 ,  A61K36/28 ,  A61K36/48 ,  Y02P20/582

    摘要： The invention relates to methods for preventing, inhibiting, or suppressing tumors by administering to a person in need of such treatment a therapeutically effective amount of one or more flavanolignanes, such as silymarin, silybin, silidianin, silicristin, dehydrosilybin, mixtures thereof, or extracts thereof as an antiproliferative. The invention further relates to the antitumor pharmaceutical composition includes a therapeutically effective amount of the flavanolignane selected from the group of silymarin, silybin, silidianin, silicristin, dehydrosilybin, and mixtures thereof, in combination with a different antitumor agent. In another embodiment, the pharmaceutical composition includes a therapeutically effective amount of a flavanolignane selected from the group of silidianin, silicristin, and mixtures thereof, with a pharmaceutically acceptable carrier or excipient. The compositions and method may be prepared or administered with different antitumoral agents for concurrent or sequential use for treating tumors, such as those typically found in the uterus, ovary, and breast.

    摘要翻译： PCT No.PCT / EP95 / 03993 Sec。 371日期：1997年11月18日 102（e）1997年11月18日日期PCT提交1995年10月10日PCT公布。 WO96 / 37209 PCT公开号 日期：1996年11月28日本发明涉及通过向需要这种治疗的人施用治疗有效量的一种或多种黄烷醇烷，如水飞蓟素，水飞蓟宾，硅胶石，硅胶，脱水滑石， 其混合物或其提取物作为抗增殖剂。 本发明还涉及抗肿瘤药物组合物，其包含与不同的抗肿瘤剂组合的治疗有效量的选自水飞蓟素，水飞蓟宾，硅胶石，硅胶，脱水壳聚糖及其混合物的黄烷醇酮。 在另一个实施方案中，药物组合物包括治疗有效量的选自硅胶蛋白，硅胶，及其混合物的黄烷醇酮与药学上可接受的载体或赋形剂。 组合物和方法可以制备或施用于不同的抗肿瘤剂，用于同时或顺序用于治疗肿瘤，例如通常在子宫，卵巢和乳腺中发现的肿瘤。

    Use of a ginkgo complexes for the enhancement of cognitive functions and the alleviation of mental fatigue
    17.
    发明授权
    Use of a ginkgo complexes for the enhancement of cognitive functions and the alleviation of mental fatigue 有权
    使用银杏复合物来增强认知功能和减轻精神疲劳

    公开(公告)号：US08591965B2

    公开(公告)日：2013-11-26

    申请号：US10587468

    申请日：2005-01-26

    申请人： Paolo Morazzoni ,  Orlando Petrini ,  Andrew Scholey ,  David Kennedy

    发明人： Paolo Morazzoni ,  Orlando Petrini ,  Andrew Scholey ,  David Kennedy

    IPC分类号： A61K36/00 ,  A61K36/16 ,  A61K36/87

    CPC分类号： A61K36/16 ,  A23L33/105 ,  A23V2002/00 ,  A61K2300/00 ,  A23V2200/322 ,  A23V2250/2122 ,  A23V2250/1852

    摘要： The use of Ginkgo complexed with phosphatidylserine for the manufacture of a medicament or a dietary supplement for the enhancement of cognitive function and alleviation of mental fatigue, i.e. to improve the speed of memory and memory quality, to increase accuracy and attention in activities in normal healthy subjects, to prevent deterioration of the speed and quality of memory in people with decreased cognitive functions, to counteract cognitive fatigue, and also having an influence on the mood, particularly in healthy children, young adults, middle-aged and/or old people. It is further provided the use of the Ginkgo-phosphatidylserine complex for the treatment and prevention of disease related with decreased cognitive function and increased mental fatigue such as Dementia, and Alzheimer's Disease.

    摘要翻译： 与磷脂酰丝氨酸配合使用的银杏用于制造用于提高认知功能和减轻精神疲劳的药物或膳食补充剂，即提高记忆和记忆质量的速度，增加正常健康活动中的准确性和注意力 科目，以防止认知功能降低的人的记忆速度和质量下降，抵消认知疲劳，并对心情有影响，特别是对健康儿童，青少年，中老年人的影响。 进一步提供了银杏磷脂酰丝氨酸复合物用于治疗和预防与认知功能降低相关的疾病和增加的精神疲劳如痴呆和阿尔茨海默病的用途。