Space Efficient Tool Chest Assembly
    11.
    发明申请
    Space Efficient Tool Chest Assembly 审中-公开
    空间高效工具箱组装

    公开(公告)号:US20070290583A1

    公开(公告)日:2007-12-20

    申请号:US11424279

    申请日:2006-06-15

    CPC classification number: B25H3/026

    Abstract: A tool chest assembly includes a lower cabinet and an upper cabinet. The upper cabinet is configured to fit inside the lower cabinet during shipping or storage to save space. The tool chest assembly is configured for easy set-up and handling.

    Abstract translation: 工具箱组件包括下机柜和上机柜。 上部机柜配置为在运输或存储期间安装在下机柜内部,以节省空间。 工具箱组件配置为便于设置和处理。

    Anti human ovarian cancer-anti CD3 bispecific antibody
    12.
    发明授权
    Anti human ovarian cancer-anti CD3 bispecific antibody 失效
    抗人卵巢癌抗CD3双特异性抗体

    公开(公告)号:US07262276B2

    公开(公告)日:2007-08-28

    申请号:US10478345

    申请日:2002-05-23

    Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.

    Abstract translation: 本发明提供了抗卵巢癌双特异性抗体。 所述抗体包括通过多肽接头连接的两个多肽结构域,一个是抗卵巢癌抗体或其Fab片段,单互补决定区(CDR)抗体或单链Fv(scFv),另一个是抗CD3抗体,或 其Fab片段,单CDR抗体或scFv。 本发明还提供编码所述抗体的DNA序列,含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。

    Attenuation of tumor growth, metastasis and angiogenesis
    13.
    发明授权
    Attenuation of tumor growth, metastasis and angiogenesis 失效
    肿瘤生长,转移和血管生成的衰减

    公开(公告)号:US06979563B1

    公开(公告)日:2005-12-27

    申请号:US09715965

    申请日:2000-11-17

    CPC classification number: A61K38/51

    Abstract: A highly purified and specific glycosaminoglycan degrading enzyme, chondroitinase AC, and to a lesser extent, chondroitinase B, can be used in the treatment of metastatic cancers and in other disorders characterized by angiogenesis. The enzymatic removal of chondroitin sulfates A and C, and to a lesser extent, chondroitin sulfate B, from cell surfaces directly decreases the ability of tumor cells to invade blood vessels and thus prevents the formation of metastatic, or secondary tumors; inhibits tumor cell growth; and decreases angiogenesis by inhibiting both endothelial cell proliferation and capillary formation. Decreasing the formation of new blood vessels into the tumor in turn decreases the potential for tumor growth, and further decreases the ability of tumor cells to invade the bloodstream. These effects are opposite to the prometastatic effects of tumor-secreted heparanase.

    Abstract translation: 高度纯化和特异性的糖胺聚糖降解酶,软骨素酶AC和较小程度的软骨素酶B可用于治疗转移性癌症和其它以血管生成为特征的疾病。 来自细胞表面的硫酸软骨素A和C以及较低程度的硫酸软骨素酶的酶促去除直接降低肿瘤细胞侵入血管的能力,从而防止转移性或继发性肿瘤的形成; 抑制肿瘤细胞生长; 并通过抑制内皮细胞增殖和毛细血管形成来减少血管生成。 减少肿瘤新血管的形成反过来降低了肿瘤生长的可能性,进一步降低了肿瘤细胞侵入血液的能力。 这些作用与肿瘤分泌型肝素酶的前体作用相反。

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