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23 条记录 (耗时 0.032 秒)

    Indol-2-one derivatives
    11.
    发明授权
    Indol-2-one derivatives 失效
    吲哚-2-酮衍生物

    公开(公告)号：US5773612A

    公开(公告)日：1998-06-30

    申请号：US640080

    申请日：1996-04-30

    申请人： Jean Wagnon ,  Bernard Tonnerre ,  Alain Di Malta ,  Richard Roux ,  Marie-Sophie Amiel ,  Claudine Serradeil-Legal

    发明人： Jean Wagnon ,  Bernard Tonnerre ,  Alain Di Malta ,  Richard Roux ,  Marie-Sophie Amiel ,  Claudine Serradeil-Legal

    IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/535 ,  A61K31/5377 ,  A61K31/54 ,  A61K31/541 ,  A61P1/00 ,  A61P7/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/24 ,  A61P25/26 ,  A61P43/00 ,  C07D209/34 ,  C07D209/38 ,  C07D209/40 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D209/30

    CPC分类号： C07D401/04 ,  C07D209/34 ,  C07D209/38 ,  C07D209/40 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  Y02P20/55

    摘要： A compound of formula II' ##STR1## in which R.sub.I is an ethoxy group or a chlorine atom; R.sub.II is hydrogen, a chlorine atom or a methyl group; R.sub.III is a chlorophenyl group or a methoxyphenyl group; R.sub.IV is an amino group, a group NR.sub.9 R.sub.10 or NR.sub.9 R.sub.XI, or a piperazin-1-yl radical substituted in the 4-position by a (C.sub.2 -C.sub.10)alkylene group substituted by an amino group which is free or carries a protective group; R.sub.10 is (CH.sub.2).sub.p R.sub.35 or a (C.sub.2 -C.sub.10)alkylene group substituted by R.sub.21 ; R.sub.XI is a (C.sub.1 -C.sub.12)alkyl group or a group .omega.-R.sub.32 R.sub.33 N(C.sub.1 -C.sub.4)-alkylcarbonyl; and R.sub.21 is R.sub.36 ; a group OR.sub.37 ; a group NR.sub.32 R.sub.33 ; a cyano group; a group S(C.sub.1 -C.sub.7)alkyl; a group SO(C.sub.1 -C.sub.7)alkyl; or a group SO.sub.2 (C.sub.1 -C.sub.7)alkyl; R.sub.35 is a piperid-4-yl group which is unsubstituted or substituted in the 1-position by a (C.sub.1 -C.sub.7)alkoxycarbonyl group or by a (C.sub.1 -C.sub.7)alkyl group; or a pyrid-2-yl group; R.sub.37 is R.sub.13 ; a (C.sub.3 -C.sub.7)cycloalkyl group; a (C.sub.1 -C.sub.6)alkylene group substituted by R.sub.24 ; a (C.sub.2 -C.sub.6)alkylene group substituted by a hydroxyl or a (C.sub.1 -C.sub.7)alkoxy group; or a (C.sub.2 -C.sub.6)alkylene group substituted by an amino group which is free or substituted by one or two (C.sub.1 -C.sub.7)alkyl groups or by a protective group; R.sub.24 is a carboxyl group; a (C.sub.1 -C.sub.7)alkoxycarbonyl group; a benzyloxycarbonyl group; or a carbamoyl group which is free or substituted by one or two (C.sub.1 -C.sub.7)alkyl groups.

    摘要翻译： 其中RI是乙氧基或氯原子的式II'化合物（II'）; RII是氢，氯原子或甲基; RIII是氯苯基或甲氧基苯基; RIV是被无取代或携带保护基团的氨基取代的（C2-C10）亚烷基在4-位取代的氨基，NR9R10或NR9RXI基团或哌嗪-1-基; R 10为被R 21取代的（CH 2）p R 35或（C 2 -C 10）亚烷基; RXI是（C 1 -C 12）烷基或ω-R 32 R 33 N（C 1 -C 4） - 烷基羰基; R21为R36; 一组OR37; 一组NR32R33; 氰基; S（C 1 -C 7）烷基; SO（C 1 -C 7）烷基; 或基团SO 2（C 1 -C 7）烷基; R35是未被取代的或被（C1-C7）烷氧基羰基或（C1-C7）烷基取代在1位的哌啶-4-基; 或吡啶-2-基; R37是R13; （C 3 -C 7）环烷基; 被R24取代的（C1-C6）亚烷基; 被羟基或（C 1 -C 7）烷氧基取代的（C 2 -C 6）亚烷基; 或被一个或两个（C 1 -C 7）烷基或保护基取代的氨基取代的（C 2 -C 6）亚烷基; R24是羧基; （C1-C7）烷氧基羰基; 苄氧基羰基; 或不含或被一个或两个（C 1 -C 7）烷基取代的氨基甲酰基。

    4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them
    15.
    发明授权
    4-amidino pyrano (3,2-c) pyridine derivatives, and pharmaceutical compositions containing them 失效
    4-脒基吡喃并（3,2-c）吡啶衍生物，以及含有它们的药物组合物

    公开(公告)号：US5185345A

    公开(公告)日：1993-02-09

    申请号：US850994

    申请日：1992-03-12

    申请人： Georges Garcia ,  Patrick Gautier ,  Dino Nisato ,  Richard Roux

    发明人： Georges Garcia ,  Patrick Gautier ,  Dino Nisato ,  Richard Roux

    IPC分类号： C07D405/04 ,  C07D491/04 ,  C07D491/052

    CPC分类号： C07D405/04 ,  C07D491/04

    摘要： The present invention deals with 4-amidino chroman and 4-amidino pyrano (3,2-c) pyridine derivatives, a process for their preparation and pharmaceutical compositions containing them. Said derivatives have antihypertensive and antiarythmic activities. They respond to formula ##STR1## in which: A+B.dbd.--CH.dbd.CH--CH.dbd.N-- ou --CH.dbd.CR.sub.4 --CR.sub.5 .dbd.CH--; X.dbd.N,N.fwdarw.O, C--Z;R.sub.1 .dbd.H, CN, NO.sub.2, C.sub.1 -C.sub.4, alkyl, OH, C.sub.1 -C.sub.4 alkoxy, CF.sub.3 CO--, CH.sub.3 --SO.sub.2 --, .rho.--SO.sub.2 --;R.sub.2 .dbd.H;R.sub.3 .dbd.OH ou OCOCH.sub.3 ou R.sub.2 +R.sub.3 .dbd.double bond.

    摘要翻译： 本发明涉及4-脒基色满和4-脒基吡喃（3,2-c）吡啶衍生物，其制备方法和含有它们的药物组合物。 所述衍生物具有抗高血压和抗血栓活性。 它们响应式（I）其中：A + B = -CH = CH-CH = N-O -CH = CR4-CR5 = CH-; X = N，N-> O，C-Z; R1 = H，CN，NO2，C1-C4，烷基，OH，C1-C4烷氧基，CF3CO-，CH3-SO2-， R2 = H; R3 = OH o OCOCH3 ou R2 + R3 =双键。