公开(公告)号：US06368855B1

公开(公告)日：2002-04-09

申请号：US09205995

申请日：1998-12-04

申请人： Minzhen Xu ,  Gang Qiu ,  Robert Humphreys

发明人： Minzhen Xu ,  Gang Qiu ,  Robert Humphreys

IPC分类号： C12N508

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521

摘要： Disclosed is a specific regulator of Ii protein expression or immunoregulatory function. Specifically disclosed are several forms of the specific regulator of Ii, including those which function through the formation of a duplex molecule with an RNA molecule encoding mammalian Ii protein to inhibit Ii protein synthesis at the translation level. This class includes copolymers comprised of nucleotide bases which hybridize specifically to the RNA molecule encoding mammalian Ii protein, and also expressible reverse gene constructs. In other aspects, the disclosure relates to MHC class II-positive antigen presenting cells containing a specific regulator of Ii expression. Such cells are useful, for example, in the display of autodeterminant peptides in association with MHC class II proteins. Compositions of the invention find application in methods for treating diseases, for example malignancies and autoimmune disorders, in a patient by enhancing immunological attack on undesired cells. An additional application is the isolation of autodeterminant peptides from a cell.

摘要翻译： 公开了Ii蛋白表达或免疫调节功能的特异性调节剂。 具体公开的是Ii的特异性调节剂的几种形式，包括通过形成具有编码哺乳动物Ii蛋白的RNA分子的双链体分子起作用以抑制翻译水平的Ii蛋白质合成的那些形式。 该类包括与编码哺乳动物Ii蛋白的RNA分子特异性杂交的核苷酸碱基以及可表达的反向基因构建体的共聚物。 在其他方面，本公开涉及含有Ii表达特异性调节剂的MHC II类阳性抗原呈递细胞。 这样的细胞可用于例如与MHC II类蛋白相关的显示自身决定肽。 本发明的组合物可用于通过增强对不想要的细胞的免疫攻击来治疗患者中的疾病，例如恶性肿瘤和自身免疫性疾病的方法。 另外的应用是从细胞中分离出自身决定肽。

公开(公告)号：US06211583B1

公开(公告)日：2001-04-03

申请号：US09395267

申请日：1999-09-13

申请人： Scott Robert Humphreys

发明人： Scott Robert Humphreys

IPC分类号： H03M166

CPC分类号： H03K17/04106 ,  H03K17/162 ,  Y10T307/865

摘要： A high-speed current switch (36) comprises a differential switch (14), a current source (12), an op-amp (32), a feedback switch (38), a hold capacitor (40), a biasing transistor (42), and a second current switch (44). The high-speed current switch (36) receives a complementary control signal (46) and a control signal (48), and generates an output current (26).

摘要翻译： 高速电流开关（36）包括差分开关（14），电流源（12），运算放大器（32），反馈开关（38），保持电容器（40），偏置晶体管 42）和第二电流开关（44）。 高速电流开关（36）接收互补控制信号（46）和控制信号（48），并产生输出电流（26）。

公开(公告)号：US5805095A

公开(公告)日：1998-09-08

申请号：US781252

申请日：1997-01-10

申请人： Scott Robert Humphreys ,  Raymond Louis Barrett, Jr. ,  Lawrence Loren Case

发明人： Scott Robert Humphreys ,  Raymond Louis Barrett, Jr. ,  Lawrence Loren Case

IPC分类号： H03M1/66

CPC分类号： H03M1/66

摘要： A two's complement digital to analog converter (300) is for converting a two's complement binary value to an analog output current, and includes a control circuit (310) which generates controlled value bits, a digital to analog current converter (DACC) (320), and an augmenter (330). The DACC (320) generates a DACC analog current which is a portion of the analog output current and which has an absolute value which is related to the binary value of the controlled value bits. The augmenter (330), which is coupled to a most significant bit of the two's complement binary value, generates a portion of the analog output current by modifying the absolute value of the DACC analog current by a least significant bit current increment when the most significant bit indicates a negative value of the two's complement binary value.

摘要翻译： 二进制补码数模转换器（300）用于将二进制补码二进制值转换为模拟输出电流，并且包括产生受控值位的控制电路（310），数模转换器（DACC）（320） ，以及增强器（330）。 DACC（320）产生作为模拟输出电流的一部分的DACC模拟电流，其具有与控制值位的二进制值相关的绝对值。 耦合到二进制补码二进制值的最高有效位的增益器（330）通过在最高有效位电流增量时修改DACC模拟电流的绝对值来产生模拟输出电流的一部分 位表示二进制补码二进制值的负值。

公开(公告)号：US5329024A

公开(公告)日：1994-07-12

申请号：US40316

申请日：1993-03-30

申请人： Sharon H. Jureller ,  Judith L. Kerschner ,  Robert Humphreys

发明人： Sharon H. Jureller ,  Judith L. Kerschner ,  Robert Humphreys

IPC分类号： B01J31/16 ,  B01J31/18 ,  B01J31/22 ,  C07B61/00 ,  C07D301/06 ,  C07D301/12 ,  C07D303/04 ,  C07D303/38 ,  C07D301/14

CPC分类号： C07D303/38 ,  B01J31/182 ,  C07D301/12 ,  B01J2231/72 ,  B01J2531/72 ,  B01J2531/96

摘要： A method for epoxidizing olefins is provided wherein an olefin and an oxygenating agent are contacted together in the presence of a manganese complex catalyst having at least one manganese atom coordinated with a nitrogen-containing ligand such that the manganese atom to coordinated nitrogen atom is 1:3 and thereafter isolating the resultant epoxide product. Catalyst compositions are also provided formed from the adsorption of the manganese complex catalyst onto a solvent insoluble support.

摘要翻译： 提供了一种环氧化烯烃的方法，其中烯烃和氧化剂在具有与含氮配体配位的至少一个锰原子的锰络合物催化剂存在下接触在一起，使得锰原子与配位氮原子为1： 3，然后分离所得环氧化物产物。 还提供催化剂组合物，其通过将锰络合物催化剂吸附到溶剂不溶性载体上而形成。

公开(公告)号：US08857983B2

公开(公告)日：2014-10-14

申请号：US13358579

申请日：2012-01-26

申请人： Randall Braxton Pugh ,  Daniel B. Otts ,  Frederick A. Flitsch ,  Adam Toner ,  Scott Robert Humphreys

发明人： Randall Braxton Pugh ,  Daniel B. Otts ,  Frederick A. Flitsch ,  Adam Toner ,  Scott Robert Humphreys

IPC分类号： G02C7/08 ,  G02C7/04

CPC分类号： G02C7/049 ,  A61F2/1624 ,  A61F2250/0001 ,  A61F2250/0002 ,  B29D11/00038 ,  B29D11/00817 ,  G02C7/04 ,  G02C7/083 ,  H01Q1/22 ,  H01Q1/2225 ,  H01Q7/00

摘要： Antennas and antenna systems may be designed and configured for incorporation into mechanical devices, including medical devices, such as ophthalmic devices, including contact lenses. These antennas and antenna systems may be utilized to transmit data from the mechanical device to a receiver, to receive data from a transmitter, and/or to inductively charge an electromechanical cell or the like incorporated into the mechanical device.

摘要翻译： 天线和天线系统可以被设计和配置成并入到机械装置中，包括医疗装置，诸如眼科装置，包括隐形眼镜。 这些天线和天线系统可用于将数据从机械设备传送到接收机，从发射机接收数据，和/或感应地对组装在机械设备中的机电电池等进行充电。

公开(公告)号：US20130343248A1

公开(公告)日：2013-12-26

申请号：US13531874

申请日：2012-06-25

申请人： Adam Toner ,  Scott Robert Humphreys ,  Randall Braxton Pugh ,  Daniel B. Otts ,  William Chester Neeley

发明人： Adam Toner ,  Scott Robert Humphreys ,  Randall Braxton Pugh ,  Daniel B. Otts ,  William Chester Neeley

IPC分类号： H04W52/02

CPC分类号： H04W56/0085 ,  Y02D70/00 ,  Y02D70/26

摘要： A wireless protocol for a communication system is set forth herein which may be utilized for communication between a transmitter and a receiver over any type of communication channel. The wireless communication protocol provides for the reduction of receiver active or on time which in turn lowers power consumption. The wireless communication protocol enables the complexity and receiver size to be reduced. The methodology employed in the protocol utilizes a unique message frame in conjunction with repeated transmission and periodic receiver searching.

摘要翻译： 本文阐述了用于通信系统的无线协议，其可以用于任何类型的通信信道上的发射机和接收机之间的通信。 无线通信协议提供减少接收器的有效或准时，从而降低功耗。 无线通信协议使复杂度和接收机尺寸得以减小。 在协议中使用的方法利用独特的消息帧结合重复的传输和周期性的接收机搜索。

公开(公告)号：US20110038488A1

公开(公告)日：2011-02-17

申请号：US12851200

申请日：2010-08-05

申请人： Scott Robert Humphreys

发明人： Scott Robert Humphreys

IPC分类号： H04B3/00

CPC分类号： G10H1/0083

摘要： A wireless musical instrument network (400, 500) may comprise one or more wireless link modules (100, 200, 300). In some embodiments a first wireless link module may be adapted to receive a first input audio signal and transmit a first wireless signal having a modulation component based on the first input audio signal. A second wireless link module may be adapted to receive the first wireless signal and a second input audio signal. The second wireless link module may be further adapted to demodulate the first wireless signal to provide a first received audio signal, and combine the first received audio signal and the second input audio signal to provide a combined audio signal. The second wireless link module may provide a second wireless signal having a modulation component based on the combined audio signal, whereby the combined audio signal and the second wireless signal contain information based on both the first input audio signal and the second input audio signal

摘要翻译： 无线乐器网络（400,500）可以包括一个或多个无线链路模块（100,200,300）。 在一些实施例中，第一无线链路模块可以适于接收第一输入音频信号，并且基于第一输入音频信号发送具有调制分量的第一无线信号。 第二无线链路模块可以适于接收第一无线信号和第二输入音频信号。 第二无线链路模块还可以适于解调第一无线信号以提供第一接收音频信号，并且组合第一接收音频信号和第二输入音频信号以提供组合音频信号。 第二无线链路模块可以提供具有基于组合音频信号的调制分量的第二无线信号，由此组合音频信号和第二无线信号基于第一输入音频信号和第二输入音频信号两者包含信息

公开(公告)号：US07774274B2

公开(公告)日：2010-08-10

申请号：US10656798

申请日：2003-09-05

申请人： Peter Jones ,  Jim Mitchell ,  Mike Brumfitt ,  Deborah Falkingbridge ,  Robert Humphreys ,  Stewart MacPhail ,  Jeremy Schreurs ,  Amanda Atherton ,  Ros Marshall ,  Lockie Carolan ,  Jeffrey V. Manchester ,  Paul F. Richards

发明人： Peter Jones ,  Jim Mitchell ,  Mike Brumfitt ,  Deborah Falkingbridge ,  Robert Humphreys ,  Stewart MacPhail ,  Jeremy Schreurs ,  Amanda Atherton ,  Ros Marshall ,  Lockie Carolan ,  Jeffrey V. Manchester ,  Paul F. Richards

IPC分类号： G06Q40/00 ,  G07F19/00

CPC分类号： G06Q30/06 ,  G06Q20/10 ,  G06Q20/342 ,  G07F7/025

摘要： A payment card processing system and method is provided that allows an account holder to upgrade a private label card to a dual card. The dual card may be used for both private label transactions and bankcard transactions. Methods for upgrading to the dual card account include selecting a private label account having associated monetary and non-monetary data and maintained on a first processing platform for upgrade to a dual card account, creating the dual card account on a second processing platform, transferring the non-monetary data associated with the private label account from the first processing platform to the second processing platform for association with the dual card account, and initiating a trailing activity process to identify monetary and non-monetary activity associated with the private label account and update a cross reference table to associate the trailing activity with the dual card account.

摘要翻译： 提供了支付卡处理系统和方法，其允许帐户持有者将私人标签卡升级到双卡。 双卡可用于私人标签交易和银行卡交易。 升级到双卡帐户的方法包括选择具有相关联的货币和非货币数据的私有标签账户，并在第一处理平台上维护以升级到双卡账户，在第二处理平台上创建双卡帐户， 与第一处理平台相关联的第二处理平台与第二处理平台相关联的非货币数据与双卡帐户相关联，以及发起尾随活动过程以识别与私有标签帐户相关联的货币和非货币活动并更新 一个交叉引用表，用于将尾随活动与双卡帐户相关联。

公开(公告)号：US20100150953A1

公开(公告)日：2010-06-17

申请号：US12635656

申请日：2009-12-10

申请人： Robert Humphreys ,  Minzhen Xu

发明人： Robert Humphreys ,  Minzhen Xu

IPC分类号： A61K39/385 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K2039/55516 ,  A61K2039/55522

摘要： Provided are methods and compositions for treating cancer in humans, the cancer being characterized by expression of Her-2/neu. The methods involve vaccinating a patient with an Ii-Key/MHC class II hybrid construct and thereby stimulating an immune response to the native Her-2/neu protein. The construct may be in the form of an Ii-Key hybrid peptide or a nucleic acid encoding an Ii-Key hybrid peptide. Methods are described wherein the cancer being treated is breast cancer. Also claimed is a pharmaceutical composition comprising an Ii-Key/MHC class II hybrid construct with and without an adjuvant. The adjuvant can include GM-CSF. The Ii-Key hybrid construct includes the LRMK residues of Ii-Key protein and an MHC Class II epitope of a protein or portion thereof which is used in the vaccine or a DNA encoding the same hybrid peptide.

摘要翻译： 提供用于治疗人类癌症的方法和组合物，该癌症的特征在于Her-2 / neu的表达。 所述方法涉及用Ii-Key / MHC II类杂交构建体接种患者，从而刺激对天然Her-2 / neu蛋白的免疫应答。 构建体可以是Ii-Key杂交肽或编码Ii-Key杂交肽的核酸的形式。 描述了其中所治疗的癌症是乳腺癌的方法。 还要求保护的是包含具有和不具有佐剂的Ii-Key / MHC II类杂交构建体的药物组合物。 佐剂可以包括GM-CSF。 Ii-Key杂交构建体包括Ii-Key蛋白的LRMK残基和用于疫苗的蛋白质或其部分的MHC II类表位或编码相同杂交肽的DNA。

公开(公告)号：US20090060936A1

公开(公告)日：2009-03-05

申请号：US12002083

申请日：2007-12-13

申请人： Robert Humphreys ,  Minzhen Xu

发明人： Robert Humphreys ,  Minzhen Xu

IPC分类号： A61K39/385 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K2039/55516 ,  A61K2039/55522

摘要： Provided are methods and compositions for treating cancer in humans, the cancer being characterized by expression of Her-2/neu. The methods involve vaccinating a patient with an Ii-Key/MHC class II hybrid construct and thereby stimulating an immune response to the native Her-2/neu protein. The construct may be in the form of an Ii-Key hybrid peptide or a nucleic acid encoding an Ii-Key hybrid peptide. Methods are described wherein the cancer being treated is breast cancer. Also claimed is a pharmaceutical composition comprising an Ii-Key/MHC class II hybrid construct with and without an adjuvant. The adjuvant can include GM-CSF. The Ii-Key hybrid construct includes the LRMK (SEQ ID NO: 2) residues of Ii-Key protein and an MHC Class II epitope of a protein or portion thereof which is used in the vaccine or a DNA encoding the same hybrid peptide.

摘要翻译： 提供用于治疗人类癌症的方法和组合物，该癌症的特征在于Her-2 / neu的表达。 所述方法涉及用Ii-Key / MHC II类杂交构建体接种患者，从而刺激对天然Her-2 / neu蛋白的免疫应答。 构建体可以是Ii-Key杂交肽或编码Ii-Key杂交肽的核酸的形式。 描述了其中所治疗的癌症是乳腺癌的方法。 还要求保护的是包含具有和不具有佐剂的Ii-Key / MHC II类杂交构建体的药物组合物。 佐剂可以包括GM-CSF。 Ii-Key杂交构建体包括用于疫苗的蛋白质或其部分的Ii-Key蛋白的LRMK（SEQ ID NO：2）残基和MHC II类表位或编码相同杂交肽的DNA。