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11.发明授权公开(公告)号：US09988381B2
公开(公告)日：2018-06-05
申请号：US14895832
申请日：2014-06-18
申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD.
发明人： Jingkang Shen , Meiyu Geng , Jian Ding , Bing Xiong , Jing Al , Yuchi Ma , Xin Wang , Xia Peng , Yuelei Chen , Danqi Chen , Tao Meng , Lanping Ma , Yinchun Ji
IPC分类号： C07D471/04 , C07D519/00 , C07D487/04 , C07D495/04
CPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , C07D519/00
摘要： This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of producing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumors associated with abnormal protein tyrosine kinase.
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12.发明申请公开(公告)号：US20220280541A1
公开(公告)日：2022-09-08
申请号：US17631814
申请日：2020-08-05
申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Meiyu Geng , Guangqiang Sun , Xinyi Wang , Jing Zhang , Teng Feng
摘要： The present invention relates to identification of a carbohydrate drug-sensitive patient in patients having Alzheimer's disease. The present invention provides a method for identifying a carbohydrate drug-sensitive patient in patients having Alzheimer's disease.
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公开(公告)号：US10898508B2
公开(公告)日：2021-01-26
申请号：US15576454
申请日：2016-05-20
发明人： Zhenqing Zhang , Jie Hao , Shichang Sun , Huiling Zhang
摘要： An oxidized β-1,4-oligoglucuronic acid, and a preparation method therefor and uses thereof. By using abundant cellulose in the natural world as the raw material, all 6-site hydroxyl groups of the cellulose β-1,4-polyglucose is oxidized into carboxyl groups to form glucuronic acid under the action of a sodium bromide (NaBr)-2,2,6,6-tetramethyl piperidine oxide (TEMPO)-sodium hypochlorite (NaClO) oxidation system, and the oxidized oligoglucuronic acid having an open ring at an end is prepared by controlling reaction conditions. The compound has obvious anti-cerebral ischemia activity, and can be developed into a potential anti-cerebral ischemia drug.
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14.发明申请公开(公告)号：US20210010984A1
公开(公告)日：2021-01-14
申请号：US16763139
申请日：2018-09-06
发明人： Zhenqing Zhang , Yangyang Zeng
摘要： The invention belongs to the technical field of natural medicinal chemistry and quality control thereof, and relates to a method for determining the weight average molecular weight and the purity of a soluble salt of an acidic saccharide. The method comprises using metal ion content in the soluble salt of an acidic saccharide to correct the weight average molecular weight and the content of the of acid saccharide obtained by the combined use of the molecular sieve chromatography and a multi-angle laser scattering detector SEC-MALS. The method of the present invention can be used to more quickly and accurately determine the weight average molecular weight and content of acidic saccharide soluble salts.
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公开(公告)号：US10259798B2
公开(公告)日：2019-04-16
申请号：US15301265
申请日：2015-02-09
申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES , SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD.
发明人： Lijiang Xuan , Yiping Wang , Weibin Song , Chunguang Chen , Dingxiang Li , Xiaoyu Zhou , Yunlong Gu , Liang Hu , Jing Zhao , Wenwei Xu , Shumei Wang
IPC分类号： A61K36/00 , C07D307/86 , A61K31/343 , A61K36/537
摘要： The present invention relates to a method for preparing magnesium lithospermate B. The method is characterized in that: magnesium lithospermate B is extracted or purified from a Salvia miltiorrhiza plant material or a Salvia miltiorrhiza extract in the presence of an added magnesium salt. The present invention also relates to a high-purity magnesium lithospermate B product prepared by the method of the present invention, wherein the content of magnesium lithospermate B is more than 95% by weight.
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16.发明申请公开(公告)号：US20180207194A1
公开(公告)日：2018-07-26
申请号：US15576454
申请日：2016-05-20
发明人： Zhenqing ZHANG , Jie HAO , Shichang SUN , Huiling ZHANG
IPC分类号： A61K31/715 , A61P9/10 , A61P25/00
摘要： An oxidized β-1,4-oligoglucuronic acid, and a preparation method therefor and uses thereof. By using abundant cellulose in the natural world as the raw material, all 6-site hydroxyl groups of the cellulose β-1,4-polyglucose is oxidized into carboxyl groups to form glucuronic acid under the action of a sodium bromide (NaBr)-2,2,6,6-tetramethyl piperidine oxide (TEMPO)-sodium hypochlorite (NaClO) oxidation system, and the oxidized oligoglucuronic acid having an open ring at an end is prepared by controlling reaction conditions. The compound has obvious anti-cerebral ischemia activity, and can be developed into a potential anti-cerebral ischemia drug.
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公开(公告)号：US20170137399A1
公开(公告)日：2017-05-18
申请号：US15301265
申请日：2015-02-09
申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF SCIENCES , SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD.
发明人： Lijiang Xuan , Yiping Wang , Weibin Song , Chunguang Chen , Dingxiang Li , Xiaoyu Zhou , Yunlong Gu , Liang Hu , Jing Zhao , Wenwei Xu , Shumei Wang
IPC分类号： C07D307/86
CPC分类号： C07D307/86 , A61K31/343 , A61K36/537
摘要： The present invention relates to a method for preparing magnesium lithospermate B. The method is characterized in that: magnesium lithospermate B is extracted or purified from a Salvia miltiorrhiza plant material or a Salvia miltiorrhiza extract in the presence of an added magnesium salt. The present invention also relates to a high-purity magnesium lithospermate B product prepared by the method of the present invention, wherein the content of magnesium lithospermate B is more than 95% by weight.
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公开(公告)号：US20220280589A1
公开(公告)日：2022-09-08
申请号：US17631807
申请日：2020-08-05
申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Meiyu Geng , Guangqiang Sun , Xinyi Wang , Jing Zhang , Teng Feng
摘要： Provided is a use of an agent for regulating an amino acid level in preparing a drug for treating Alzheimer's disease in a subject.
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公开(公告)号：US20220280578A1
公开(公告)日：2022-09-08
申请号：US17631738
申请日：2020-08-05
申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Meiyu Geng , Guangqiang Sun , Xinyi Wang , Jing Zhang , Teng Feng
IPC分类号： A61K35/741 , A61K49/00 , A61K38/17 , A61P25/28
摘要： The present invention relates to the treatment of Alzheimer's disease. Provided is the use of an reagent for regulating the relative abundance of intestinal microorganisms in the preparation of a medicament for treating Alzheimer's disease in a subjet.
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公开(公告)号：US20210361684A1
公开(公告)日：2021-11-25
申请号：US17256950
申请日：2019-06-28
申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Meiyu Geng , Xianliang Xin , Zhenqing Zhang , Jian Ding
IPC分类号： A61K31/702 , A61K31/715 , A61K31/7016 , A61K31/7004 , A61P25/04 , A61P25/06
摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of pain.
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