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公开(公告)号：US20210010984A1
公开(公告)日：2021-01-14
申请号：US16763139
申请日：2018-09-06
发明人： Zhenqing Zhang , Yangyang Zeng
摘要： The invention belongs to the technical field of natural medicinal chemistry and quality control thereof, and relates to a method for determining the weight average molecular weight and the purity of a soluble salt of an acidic saccharide. The method comprises using metal ion content in the soluble salt of an acidic saccharide to correct the weight average molecular weight and the content of the of acid saccharide obtained by the combined use of the molecular sieve chromatography and a multi-angle laser scattering detector SEC-MALS. The method of the present invention can be used to more quickly and accurately determine the weight average molecular weight and content of acidic saccharide soluble salts.
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公开(公告)号：US20210032374A1
公开(公告)日：2021-02-04
申请号：US16967345
申请日：2019-02-02
摘要： The present application relates to the field of medicine. The present application relates to an isolated Saposhnikovia divaricata polysaccharide and use thereof in the manufacture of a medicament for treating diabetes mellitus or hyperlipoidemia. In particular, the present application relates to an isolated Saposhnikovia divaricata polysaccharide comprising L-arabinose, D-galacturonic acid, D-mannose, D-glucose and D-galactose, wherein the molar ratio of the L-arabinose: D-galacturonic acid: D-mannose: D-glucose: D-galactose is 1-15:1-10:1-10:10-40:1-15, preferably 1-5:5-10:1-5:20-25:1-5.
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公开(公告)号：US11366086B2
公开(公告)日：2022-06-21
申请号：US16763139
申请日：2018-09-06
发明人： Zhenqing Zhang , Yangyang Zeng
摘要： The invention belongs to the technical field of natural medicinal chemistry and quality control thereof, and relates to a method for determining the weight average molecular weight and the purity of a soluble salt of an acidic saccharide. The method comprises using metal ion content in the soluble salt of an acidic saccharide to correct the weight average molecular weight and the content of the of acid saccharide obtained by the combined use of the molecular sieve chromatography and a multi-angle laser scattering detector SEC-MALS. The method of the present invention can be used to more quickly and accurately determine the weight average molecular weight and content of acidic saccharide soluble salts.
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公开(公告)号：US20200376021A1
公开(公告)日：2020-12-03
申请号：US16967391
申请日：2019-02-02
IPC分类号： A61K31/715 , A61P3/06
摘要： Provided herein are an isolated Imperata cylindrica polysaccharide and use thereof in the manufacture of a medicament for treating hyperlipoidemia. The Imperata cylindrica polysaccharide comprises L-arabinose, D-xylose, D-mannose, D-glucose and D-galactose, wherein the molar ratio of the L-arabinose:D-xylose:D-mannose:D-glucose:D-galactose is 1-20:1-15:1-15:15-40:25-60.
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公开(公告)号：US10898508B2
公开(公告)日：2021-01-26
申请号：US15576454
申请日：2016-05-20
发明人： Zhenqing Zhang , Jie Hao , Shichang Sun , Huiling Zhang
摘要： An oxidized β-1,4-oligoglucuronic acid, and a preparation method therefor and uses thereof. By using abundant cellulose in the natural world as the raw material, all 6-site hydroxyl groups of the cellulose β-1,4-polyglucose is oxidized into carboxyl groups to form glucuronic acid under the action of a sodium bromide (NaBr)-2,2,6,6-tetramethyl piperidine oxide (TEMPO)-sodium hypochlorite (NaClO) oxidation system, and the oxidized oligoglucuronic acid having an open ring at an end is prepared by controlling reaction conditions. The compound has obvious anti-cerebral ischemia activity, and can be developed into a potential anti-cerebral ischemia drug.
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公开(公告)号：US20210322449A1
公开(公告)日：2021-10-21
申请号：US17256889
申请日：2019-06-28
申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Meiyu Geng , Xianliang Xin , Zhenqing Zhang , Jian Ding
IPC分类号： A61K31/702 , A61K31/7012 , A61K31/7016 , A61K31/715 , A61P3/10
摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of diabetes.
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公开(公告)号：US20200055888A1
公开(公告)日：2020-02-20
申请号：US16325961
申请日：2016-08-15
发明人： Zhongping Xiao , Zhenqing Zhang , Meiyu Geng , Jian Ding
摘要： The invention relates to a new method of preparing oligomannuronic diacids, important bioactives. The method utilizes oligomannuronic acids as starting materials and the target substances are obtained by acid degradation and active hypobromous acid oxidation steps. The method of preparing oligomannuronic diacids according to the invention employs moderate reaction conditions, has few side reactions, does not need further purification, achieves a yield of more than 90%, or even more than 95%, and is suitable for production with an on-line continuous reactor device, with reaction processes easy to implement automatic control.
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公开(公告)号：US20210268006A1
公开(公告)日：2021-09-02
申请号：US17256738
申请日：2019-06-28
申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Meiyu Geng , Xianliang Xin , Xiaoguang Du , Zhenqing Zhang , Jian Ding
IPC分类号： A61K31/702 , A61P25/28
摘要： The present invention relates to the application of mannuronic diacid oligosaccharide composition in the treatment of vascular dementia.
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公开(公告)号：US20210260089A1
公开(公告)日：2021-08-26
申请号：US17256807
申请日：2019-06-28
申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Meiyu Geng , Xianliang Xin , Xiaoguang Du , Zhenqing Zhang , Jian Ding
IPC分类号： A61K31/7032 , A61K31/716 , A61P25/16
摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of Parkinson's disease.
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公开(公告)号：US20210361684A1
公开(公告)日：2021-11-25
申请号：US17256950
申请日：2019-06-28
申请人： SHANGHAI GREEN VALLEY PHARMACEUTICAL CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Meiyu Geng , Xianliang Xin , Zhenqing Zhang , Jian Ding
IPC分类号： A61K31/702 , A61K31/715 , A61K31/7016 , A61K31/7004 , A61P25/04 , A61P25/06
摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of pain.
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