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公开(公告)号：US20110197290A1
公开(公告)日：2011-08-11
申请号：US13025373
申请日：2011-02-11
IPC分类号： A01K67/027 , C12N5/07 , C12N5/10 , C12N15/87
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/108 , A01K2267/03 , A01K2267/0306 , C07K14/4702 , C07K14/4708 , C07K14/705 , C12N15/873 , C12N15/907 , C12N2015/8536
摘要： Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells to a transfection agent and reseeding the group with additional cells that have not been exposed to the agent. The transgenic animals are useful for medical and scientific animal models of human diseases and conditions, as well as sources for cells, tissues, and biomaterials.
摘要翻译： 包括选自低密度脂蛋白受体基因LDLR，杜丝肌营养不良（DMD）基因和无毛基因（HR））的内源基因的基因组破坏的猪动物模型。 制备用于制备转基因动物的转染细胞的方法，包括将第一组细胞暴露于转染试剂，并用未暴露于该试剂的另外的细胞重新接种该组。 转基因动物可用于人类疾病和病症的医学和科学动物模型，以及细胞，组织和生物材料的来源。
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公开(公告)号：US09074224B2
公开(公告)日：2015-07-07
申请号：US12869232
申请日：2010-08-26
CPC分类号： C12N15/85 , A61K48/00 , C07K14/00 , C07K2319/09 , C07K2319/81 , C12N15/90 , C12N2770/14022 , C12N2800/30
摘要： Disclosed herein are methods and compositions for gene targeting utilizing fusion molecules comprising a recombinase domain and a sequence-specific DNA-binding domain.
摘要翻译： 本文公开了利用包含重组酶结构域和序列特异性DNA结合结构域的融合分子进行基因靶向的方法和组合物。
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公开(公告)号：US08518701B2
公开(公告)日：2013-08-27
申请号：US13467588
申请日：2012-05-09
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/108 , A01K2267/03 , A01K2267/0306 , C07K14/4702 , C07K14/4708 , C07K14/705 , C12N15/873 , C12N15/907 , C12N2015/8536
摘要： Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells to a transfection agent and reseeding the group with additional cells that have not been exposed to the agent. The transgenic animals are useful for medical and scientific animal models of human diseases and conditions, as well as sources for cells, tissues, and biomaterials.
摘要翻译： 包括选自低密度脂蛋白受体基因LDLR，杜丝肌营养不良（DMD）基因和无毛基因（HR））的内源基因的基因组破坏的猪动物模型。 制备用于制备转基因动物的转染细胞的方法，包括将第一组细胞暴露于转染试剂，并用未暴露于该试剂的另外的细胞重新接种该组。 转基因动物可用于人类疾病和病症的医学和科学动物模型，以及细胞，组织和生物材料的来源。
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14.发明申请USING CYTOSINE DEAMINASES TO DIMINISH RETROELEMENT TRANSFER FROM PIGS TO HUMANS 审中-公开使用细胞因子杀伤剂从皮肤转移到人类的二维转移公开(公告)号：US20090049563A1
公开(公告)日：2009-02-19
申请号：US12243711
申请日：2008-10-01
IPC分类号： A01K67/027
CPC分类号： C12N9/78 , A01K67/0273 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/108 , A01K2267/02 , A01K2267/025 , A01K2267/0337 , C12N15/8509 , C12N2517/02 , C12N2740/13011
摘要： Transgenic pigs that express one or more non-porcine cytosine deaminases are described as well as methods of making and using such pigs.
摘要翻译： 描述了表达一种或多种非猪胞嘧啶脱氨酶的转基因猪以及制造和使用这些猪的方法。
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15.发明授权Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell 有权用于将核酸引入细胞DNA的核酸转移载体公开(公告)号：US07160682B2
公开(公告)日：2007-01-09
申请号：US10191698
申请日：2002-07-09
CPC分类号： C12N15/90 , A01K2217/05 , A01K2227/40 , C12N9/22 , C12N2800/60 , C12N2800/90 , C12N2830/006 , C12N2830/80 , C12N2840/203 , C12N2840/44
摘要： The present invention provides for transposon vectors encoding expression control region-traps and gene-traps. Also provided are dicistronic vectors. Certain embodiments of the invention contain internal ribosome entry sites.
摘要翻译： 本发明提供编码表达控制区 - 陷阱和基因陷阱的转座子载体。 还提供了双顺反子载体。 本发明的某些实施方案含有内部核糖体进入位点。
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