公开(公告)号：US20240207045A1

公开(公告)日：2024-06-27

申请号：US17906332

申请日：2022-06-16

Applicant: SHEBA IMPACT LTD.

Inventor： Boris Orlov ,  Ehud Raanani

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2220/0008 ,  A61F2230/005 ,  A61F2250/001

Abstract: Apparatus and methods are described for use with a native tricuspid valve of a heart of a mammalian subject. A valve frame (22) includes a valve-frame body (32) that is configured to support prosthetic valve leaflets (20) within the native tricuspid valve. Chord-recruiting arms (30) are configured to extend from the valve-frame body at circumferential regions corresponding to the anterior leaflet and the posterior leaflet of the native tricuspid valve. An anchoring arm (28) is configured to extend from the valve-frame body at a circumferential region corresponding to the septal leaflet of the native tricuspid valve, the anchoring arm (28) being longer than each of the chord-recruiting arms (30). Other applications are also described.

公开(公告)号：US20240148315A1

公开(公告)日：2024-05-09

申请号：US18281374

申请日：2022-03-10

Applicant: SHEBA IMPACT LTD.

Inventor： Meir PLOTNIK-PELEG ,  Yotam HAGUR-BAHAT ,  Oran BEN-GAL ,  Lotem KRIBUS-SHMIEL ,  Evyatar ARAD ,  Meytal WILF ,  Noam GALOR

IPC: A61B5/00 ,  A61B5/11 ,  G06F3/01 ,  G06T19/00 ,  G16H50/30

CPC classification number: A61B5/4088 ,  A61B5/1124 ,  A61B5/1127 ,  A61B5/4884 ,  A61B5/7246 ,  G06F3/011 ,  G06F3/017 ,  G06T19/006 ,  G16H50/30

Abstract: A method of implementing an extended reality (XR) neuropsychological test of a person, including projecting onto an immersive display configured to display to the person three-dimensionally a series of virtual objects and conducting a cognitive test measuring executive functions using the virtual objects; simultaneously commanding sensors to monitor motor skills including at least one of: (i) gross hand movement by commanding a motion sensor, (ii) head movement by commanding a motion sensor, (iii) an eye movement of the person by commanding eye tracking, (iv) a gait by commanding at least one of mobility sensors, motion capture system sensors, force plate sensors or insole sensors and (v) postural stability by commanding at least one of mobility sensors, force plate sensors and insole sensors, and integrating the signals from the sensors so as to determine a neurocognitive and/or motor level of the person and produce output. Affect may also be measured.

公开(公告)号：US12208003B2

公开(公告)日：2025-01-28

申请号：US18103671

申请日：2023-01-31

Applicant: SHEBA IMPACT LTD.

Inventor： Boris Orlov ,  Ehud Raanani

IPC: A61F2/24 ,  A61F2/95

Abstract: Apparatus and methods are described herein including an expandable prosthetic mitral valve device that includes a first component configured to be deployed in a left atrium of the subject and a second component configured to be deployed in a left ventricle of the subject. At least one approximating component approximates the first and second components with respect to each other, such that, when the first and said second components are in an approximated configuration with respect to each other, one or more leaflets of the native mitral valve are trapped within the gap between a ventricular part and an annulus part. The approximating component secures the annulus part and the ventricular part in the approximated configuration. Other applications are also described.

公开(公告)号：US20240428415A1

公开(公告)日：2024-12-26

申请号：US18684119

申请日：2022-08-15

Applicant: SHEBA IMPACT LTD. ,  A.Y.Y.T. - TECHNOLOGICAL APPLICATIONS AND DATA UPDATE LTD.

Inventor： Tima DAVIDSON ,  Johnatan NISSAN ,  Amit MELAMED ,  Moriel GINDI ,  Dror MALKA

IPC: G06T7/00 ,  G06T7/11 ,  G06T7/174 ,  G06T7/32

Abstract: A system for monitoring treatment of a patient includes data input and output utilities, memory, and a data processor, and communicates with an image data provider to receive therefrom image data indicative of combined PET-CT scan images including at least one first and at least one second pre-treatment full body scan image of a patient. The data processor includes an identifier utility that processes the image data to identify matching first and second 2D regions in, respectively, first 2D slices forming the first scan image and second 2D slices forming the second scan image, and locate at least one pair of corresponding first and second 3D regions in the scan images; and an analyzer that analyzes each pair of the first and second 3D regions and determine a change in at least one parameter in the first and second 3D regions, and generate output data indicative of said change.

公开(公告)号：US20240416147A1

公开(公告)日：2024-12-19

申请号：US18732657

申请日：2024-06-04

Applicant: Vision RT Limited ,  Sheba Impact Ltd.

Inventor： Gideon Matthew HALE ,  Norman Ronald SMITH ,  Zvi SYMON ,  Sergey DUBINSKI ,  Benjamin STRAWBRIDGE

IPC: A61N5/10 ,  A61M16/00

Abstract: The present disclosure relates to a hybrid continuous positive pressure and surface imaging system for use in a radiotherapy system, including: a positive pressure unit adapted to apply a continuous positive pressure to lungs of a patient during radiotherapy; a surface camera system configured to continuously, or at intervals, capture body surface images of the patient; and a processing unit configured to continuously, or at intervals, model chest and/or abdominal movement of the patient in response to the applied continuous positive pressure based on the body surface images. The disclosure further relates to a computer-implemented method of providing real-time feedback to a positive pressure unit.

公开(公告)号：US20240415820A1

公开(公告)日：2024-12-19

申请号：US18702029

申请日：2022-10-16

Applicant: SHEBA IMPACT LTD.

Inventor： Dror MEIROW

IPC: A61K31/439 ,  A61K38/22 ,  A61P15/08

Abstract: The present disclosure provides combinations inhibitors of phosphatidylinositol 3-kinase (PI3K) pathway and agonists of anti-Mullerian hormone receptor type 2 (AMHR2), compositions and kits comprising the same, methods and uses thereof for retaining Primordial Follicle (PMF) reserve and increasing fertility.

公开(公告)号：US20240247315A1

公开(公告)日：2024-07-25

申请号：US18577231

申请日：2022-07-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  SHEBA IMPACT LTD.

Inventor： Shaul Shalev Itzkovitz ,  Keren Bahar Halpern ,  Adi Egozi ,  Shomron Silan Ben-Horin ,  Bella Ungar ,  Shani Ben-Moshe

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: A method of diagnosing an inflammatory bowel disease (IBD) of a subject is disclosed. The method comprises analyzing the RNA expression level of particular human gene in a fecal RNA sample of the subject, wherein when the expression level is above a predetermined amount it is indicative of the inflammatory bowel disease.

公开(公告)号：US20240319194A1

公开(公告)日：2024-09-26

申请号：US18574790

申请日：2022-06-29

Applicant: Sheba Impact Ltd.

Inventor： Doron YABLECOVITCH ,  Ido LAISH

IPC: G01N33/574 ,  A61K45/06

CPC classification number: G01N33/57438 ,  A61K45/06

Abstract: A method of diagnosing pancreatic cancer in a subject in need thereof is provided. The method comprising determining a level of at least syndecan 1 (SDC1) in a blood sample or a fraction thereof of the subject, wherein when the level of SDC1 is above a predetermined threshold, the subject is diagnosed with pancreatic cancer.

公开(公告)号：US20240193764A1

公开(公告)日：2024-06-13

申请号：US18286567

申请日：2022-04-13

Applicant: Sheba Impact Ltd. ,  Sami ShamoonCollege of Engineeringn(R.A0

Inventor： Chen SPETER ,  Doron MANZUR ,  Chen GILADI

IPC: G06T7/00 ,  A61B8/08 ,  G06T7/11 ,  G06T7/70 ,  G06T15/00

CPC classification number: G06T7/0012 ,  A61B8/488 ,  G06T7/11 ,  G06T7/70 ,  G06T15/00 ,  G06T2207/10132 ,  G06T2207/30104

Abstract: There is provided a method for reconstructing a 3D image, comprising: obtaining Doppler ultrasound images depicting a blood vessel and measurement of blood flow in the blood vessel, and 2D camera images captured by a camera depicting fiducial objects randomly distributed within a viscous material and spaced apart by random distances on a surface of the individual, computing 3D coordinates within a world coordinate system for pixels of the Doppler images using an external reference of an ultrasound transducer pose computed by analysis of relative changes in locations of the fiducial objects within sequential camera images, and computing a respective estimated blood flow for pixels of the Doppler images at locations within the blood vessel, reconstructing a 3D image from 3D voxels computed from the 3D coordinates of pixels of the Doppler images, including respective estimated blood flow, wherein the 3D image depicts the blood vessel and blood flow.

公开(公告)号：US20240067742A1

公开(公告)日：2024-02-29

申请号：US18375657

申请日：2023-10-02

Applicant: 4C BIOMED LIMITED ,  SHEBA IMPACT LTD.

Inventor： Eyal GREENBERG ,  Gilli GALORE-HASKEL ,  Efrat MERHAVI-SHOHAM ,  Gal MARKEL

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/68

CPC classification number: C07K16/2878 ,  A61P35/00 ,  G01N33/6863 ,  C07K2317/565 ,  G01N2800/52

Abstract: Antibodies or antigen binding fragments thereof that bind HVEM, inhibit HVEM-BTLA interaction and allow binding to LIGHT are provided. Methods of treating disease with these antibodies or antigen binding fragments thereof, nucleic acid molecules encoding these antibodies or antigen binding fragments thereof and kits comprising these antibodies or antigen binding fragments thereof are also provided.