摘要:
Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.
摘要:
An array substrate includes a base substrate and a contact part. The contact part is disposed on the base substrate. The contact part includes a first metal pattern, a disconnection control pattern and a connecting pattern. The second metal pattern is disposed on a layer different from the first metal pattern, the disconnection control pattern overlaps a side surface of the second metal pattern and a connecting pattern is formed on the first and second metal patterns and the disconnection control pattern and connects the first metal pattern with the second metal pattern.
摘要:
A mobile terminal and a method of providing a video call using the same are disclosed. More particularly, a mobile terminal capable of supporting a video call while ensuring user's privacy by mounting a three-dimensional depth camera and a two-dimensional camera in the mobile terminal and a method of providing a video call using the same are disclosed. The mobile terminal of the present invention includes a 2D camera 200 capturing a 2D video and a 3D depth camera 210 capturing a 3D depth video; an individual image separation module 112 extracting boundary information between a user and a background by using depth information regarding a video captured by the 3D depth camera 210; a composite video generation module 114 separating the user video from the video captured by the 2D camera 200 by using the extracted boundary information and composing the separated user video and the set background video.
摘要:
The present invention relates to new heterocyclic compounds containing nitrogen atoms or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same for treatment of cancer. The compounds according to the present invention induce DNA damage due to reactive oxygen species to activate c-abl and p53, induce RhoB to generate apoptosis, and induce cell death by down-regulating Bcl2 involved in cell survival, which is generated by dysregulated signals via the mitochondria pathway, thereby inhibiting tumor cell growth and inducing apoptosis. Accordingly, the composition according to the present invention can be used to treat cancer.
摘要:
A head drum assembly for a compact-size camcorder such as a digital video camera comprised of a drum cover, stationary and rotating drum, a subcircuit board, a stationary and rotating transformer and a motor stator and rotor. By forming the drum cover, which is attached to the shaft of the rotary drum above the rotary drum, with a conductive material such as an aluminum alloy, the need for a conductive bushing member and earthing plate for the insulating drum cover of the head drum assembly can be omitted, resulting in an overall simpler. As the number of components and manufacturing steps decreases, the manufacturing costs decrease and productivity increases.
摘要:
Disclosed is a head drum assembly of a tape recorder. An elastic body is mounted between upper and lower bearings as preloading means, in which the upper and lower bearings are interposed between a rotary drum and the shaft. As a result, the elastic body elastically biases the inner races of the upper and lower bearings upwardly and downwardly, respectively, whereby preload can be applied to each of the upper and lower bearings.
摘要:
An array substrate includes a base substrate and a contact part. The contact part is disposed on the base substrate. The contact part includes a first metal pattern, a disconnection control pattern and a connecting pattern. The second metal pattern is disposed on a layer different from the first metal pattern, the disconnection control pattern overlaps a side surface of the second metal pattern and a connecting pattern is formed on the first and second metal patterns and the disconnection control pattern and connects the first metal pattern with the second metal pattern.
摘要:
A mobile terminal and a method of providing a video call using the same are disclosed. More particularly, a mobile terminal capable of supporting a video call while ensuring user's privacy by mounting a three-dimensional depth camera and a two-dimensional camera in the mobile terminal and a method of providing a video call using the same are disclosed. The mobile terminal of the present invention includes a 2D camera 200 capturing a 2D video and a 3D depth camera 210 capturing a 3D depth video; an individual image separation module 112 extracting boundary information between a user and a background by using depth information regarding a video captured by the 3D depth camera 210; a composite video generation module 114 separating the user video from the video captured by the 2D camera 200 by using the extracted boundary information and composing the separated user video and the set background video.
摘要:
The present invention relates to a long-acting interferon beta formulation having improved in vivo duration and stability, comprising an interferon beta conjugate that is prepared by covalently linking interferon beta with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting interferon beta formulation of the present invention maintains in vivo activity of interferon beta at a relatively high level and remarkably increases the serum half-life thereof, thereby being used for various diseases, for which interferon is efficacious.
摘要:
Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.