摘要:
The present invention relates to new heterocyclic compounds containing nitrogen atoms or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same for treatment of cancer. The compounds according to the present invention induce DNA damage due to reactive oxygen species to activate c-abl and p53, induce RhoB to generate apoptosis, and induce cell death by down-regulating Bcl2 involved in cell survival, which is generated by dysregulated signals via the mitochondria pathway, thereby inhibiting tumor cell growth and inducing apoptosis. Accordingly, the composition according to the present invention can be used to treat cancer.
摘要:
Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.
摘要:
Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.
摘要:
There is provided a novel carbamoyloxy arylalkan arylpiperazine derivative compound having abundant racemic or enantiomeric characteristics, represented by the formula 1, and pharmaceutically available salts or hydrates thereof. Also, there are provided a pharmaceutical composition for treating pain (i.e., acute or chronic pain, neuropathic pain, inflammatory pain, diabetic pain, postherpetic neuralgia, etc.), anxiety or depression including an effective amount of the compound, and a method for treating pain, anxiety or depression in mammals by administering an effective amount of the compound to the mammals in need of treatment thereof.
摘要:
The front-end integrated circuit includes a first clock unit receiving a reference clock signal from an oscillator and generating a first clock signal, a first analog front end module receiving and processing a first broadcast signal using the first clock signal, a second clock unit receiving the reference clock signal and generating a second clock signal, and a second analog front end module receiving and processing a second broadcast signal using the second clock signal.
摘要:
There is provided a novel carbamoyloxy arylalkanoyl arylpiperazine derivative compound having abundant racemic or enantiomeric characteristics, represented by the Formula 1, and pharmaceutically available salts or hydrates thereof. Also, there are provided a pharmaceutical composition for treating pain, anxiety or depression including an effective amount of the compound, and a method for treating pain, anxiety or depression in mammals by administering an effective amount of the compound to the mammals in need of treatment thereof.
摘要:
An engine-driven vehicle cooling device includes an engine room for reception of an engine, a radiator provided within the engine room for cooling down a cooling water circulating through the engine, a cooling fan positioned between the engine and the radiator for blowing an internal air present in the engine room toward the radiator, a charged air cooler smaller in size than the radiator and disposed between the radiator and the cooling fan in a parallel relationship with the radiator, a shroud provided at an intake side of the cooling fan in the engine room for obstructing a stream of the internal air heading for the charged air cooler, and an external air inlet opening provided between the shroud and the cooling fan for allowing an external air present outside the engine room to be supplied to the charged air cooler as the cooling fan is caused to rotate.
摘要:
The front-end integrated circuit includes a first clock unit receiving a reference clock signal from an oscillator and generating a first clock signal, a first analog front end module receiving and processing a first broadcast signal using the first clock signal, a second clock unit receiving the reference clock signal and generating a second clock signal, and a second analog front end module receiving and processing a second broadcast signal using the second clock signal.
摘要:
There is provided a novel carbamoyloxy arylalkanoyl arylpiperazine derivative compound having abundant racemic or enantiomeric characteristics, represented by the Formula 1, and pharmaceutically available salts or hydrates thereof. Also, there are provided a pharmaceutical composition for treating pain, anxiety or depression including an effective amount of the compound, and a method for treating pain, anxiety or depression in mammals by administering an effective amount of the compound to the mammals in need of treatment thereof.
摘要:
A method of a relay node transmitting data is provided. The method includes receiving scheduling information about a backhaul link and data from a base station; receiving channel information about an access link from relay node user equipment; performing scheduling on the access link based on the scheduling information about the backhaul link and the channel information about the access link; and relaying the data to the relay node user equipment according to a result of the scheduling. The backhaul link means a link between the base station and the relay node, and the access link means a link between the relay node and the relay node user equipment.