POLYPEPTIDE COMPLEX COMPRISING NON-PEPTIDYL POLYMER HAVING THREE FUNCTIONAL ENDS
    1.
    发明申请
    POLYPEPTIDE COMPLEX COMPRISING NON-PEPTIDYL POLYMER HAVING THREE FUNCTIONAL ENDS 有权
    包含具有三个功能末端的非肽聚合物的多肽复合物

    公开(公告)号:US20110200623A1

    公开(公告)日:2011-08-18

    申请号:US13055406

    申请日:2009-07-23

    摘要: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.

    摘要翻译: 公开了一种蛋白质复合物,其包含生理活性多肽,二聚体蛋白质和具有三个功能性末端(3-臂)的非肽基聚合物,其具有生理活性多肽和二聚体蛋白质与3-臂非 - - 肽基聚合物。 蛋白质复合物保证生理活性多肽的长效和生物稳定性。 具有维持生理活性多肽或肽的生物活性以及显着改善多肽或肽的血清半衰期的能力,蛋白质复合物可用于开发各种生理活性多肽药物的持续释放制剂。 此外,它利用包括生理活性多肽的原料,而不会显着损失,从而提高产量。 此外,它可以容易地纯化。

    Liquid formulation of long-acting human growth hormone conjugate
    5.
    发明授权
    Liquid formulation of long-acting human growth hormone conjugate 有权
    长效人生长激素结合物的液体制剂

    公开(公告)号:US09061072B2

    公开(公告)日:2015-06-23

    申请号:US13809783

    申请日:2011-07-14

    摘要: Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.

    摘要翻译: 公开了长效人生长激素(hGH)缀合物的液体制剂,其不含白蛋白,其可以长期保存长效hGH缀合物的稳定性,其中长效人生长激素 缀合物包括与免疫球蛋白Fc区连接的人生长激素,并且与天然形式相比具有延长的体内稳定性。 包含pH 5.0〜6.0缓冲液,糖醇,盐和非离子表面活性剂的hGH缀合物的液体制剂不含人血清白蛋白和潜在的病毒污染的其他有害因素,可提供优良的储存稳定性 对于由hGH多肽和具有较高分子量和体内耐久性的免疫球蛋白Fc区组成的长效hGH缀合物,与天然产物相比。

    LIQUID FORMULATION OF LONG-ACTING HUMAN GROWTH HORMONE CONJUGATE
    6.
    发明申请
    LIQUID FORMULATION OF LONG-ACTING HUMAN GROWTH HORMONE CONJUGATE 有权
    长寿命人体生长激素联合液的液体配方

    公开(公告)号:US20130115231A1

    公开(公告)日:2013-05-09

    申请号:US13809783

    申请日:2011-07-14

    IPC分类号: A61K47/48

    摘要: Disclosed is a liquid formulation of long-acting human growth hormone (hGH) conjugate, free of albumin, which can guarantee the stability of the long-acting hGH conjugate when stored over a long period of time, wherein the long-acting human growth hormone conjugate includes a human growth hormone linked to an immunoglobulin Fc region, and has a prolonged in vivo stability compared to the native form. The liquid formulation of hGH conjugate including a pH 5.0˜6.0 buffer, a sugar alcohol, a salt and a non-ionic surfactant is free of human serum albumin and other hazardous factors which are potentially contaminated with viruses, and can provide excellent storage stability customized for a long-acting hGH conjugate composed of an hGH polypeptide and an immunoglobulin Fc region which has higher molecular weight and in vivo durability, compared to the native.

    摘要翻译: 公开了长效人生长激素(hGH)缀合物的液体制剂,其不含白蛋白,其可以长期保存长效hGH缀合物的稳定性,其中长效人生长激素 缀合物包括与免疫球蛋白Fc区连接的人生长激素,并且与天然形式相比具有延长的体内稳定性。 包含pH 5.0〜6.0缓冲液,糖醇,盐和非离子表面活性剂的hGH缀合物的液体制剂不含人血清白蛋白和其他可能被病毒污染的危险因素,可以提供优良的储存稳定性 对于由hGH多肽和具有较高分子量和体内耐久性的免疫球蛋白Fc区组成的长效hGH缀合物,与天然产物相比。

    Mobile terminal and method of providing video calls using the same
    8.
    发明授权
    Mobile terminal and method of providing video calls using the same 有权
    使用相同的移动终端和提供视频呼叫的方法

    公开(公告)号:US08633961B2

    公开(公告)日:2014-01-21

    申请号:US13307828

    申请日:2011-11-30

    IPC分类号: H04N7/14

    摘要: A mobile terminal and a method of providing a video call using the same are disclosed. More particularly, a mobile terminal capable of supporting a video call while ensuring user's privacy by mounting a three-dimensional depth camera and a two-dimensional camera in the mobile terminal and a method of providing a video call using the same are disclosed. The mobile terminal of the present invention includes a 2D camera 200 capturing a 2D video and a 3D depth camera 210 capturing a 3D depth video; an individual image separation module 112 extracting boundary information between a user and a background by using depth information regarding a video captured by the 3D depth camera 210; a composite video generation module 114 separating the user video from the video captured by the 2D camera 200 by using the extracted boundary information and composing the separated user video and the set background video.

    摘要翻译: 公开了一种移动终端和使用该移动终端提供视频呼叫的方法。 更具体地,公开了能够通过在移动终端中安装三维深度摄像机和二维摄像机来确保用户隐私的支持视频呼叫的移动终端,以及使用该视频呼叫提供视频呼叫的方法。 本发明的移动终端包括捕获2D视频的2D摄像机200和捕获3D深度视频的3D深度摄像机210; 单独图像分离模块112通过使用关于由3D深度摄像机210拍摄的视频的深度信息来提取用户和背景之间的边界信息; 复合视频生成模块114,通过使用所提取的边界信息并组合分离的用户视频和设置的背景视频,分离用户视频与由2D摄像机200捕获的视频。

    TABLE TYPE INTERACTIVE 3D SYSTEM
    10.
    发明申请
    TABLE TYPE INTERACTIVE 3D SYSTEM 审中-公开
    表类型交互式3D系统

    公开(公告)号:US20120113104A1

    公开(公告)日:2012-05-10

    申请号:US13288239

    申请日:2011-11-03

    IPC分类号: G06T15/00

    摘要: A table type 3D video display device and a table type interactive user interface are disclosed. More particularly, a method for providing services such as games, education, shopping, virtual experience, or the like, of a 3D type is disclosed. The interactive 3D system of the present invention includes a table type 3D display module 210 displaying 3D videos; a spatial touch recognition module 200 monitoring a position of user's fingers interacting with the displayed 3D videos; and an interaction computing module 230 controlling the 3D display module and the spatial touch recognition module 200.

    摘要翻译: 公开了一种表格型3D视频显示装置和表型交互式用户界面。 更具体地,公开了一种用于提供3D类型的诸如游戏,教育,购物,虚拟体验等的服务的方法。 本发明的交互式3D系统包括显示3D视频的表格型3D显示模块210; 空间触摸识别模块200监视与所显示的3D视频交互的用户手指的位置; 以及控制3D显示模块和空间触摸识别模块200的交互计算模块230。