公开(公告)号：US11191476B2

公开(公告)日：2021-12-07

申请号：US16316803

申请日：2016-07-18

Applicant: UNIVERSITE D'AIX MARSEILLE (AMU) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE (AP-HM) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Viktor Jirsa ,  Christophe Bernard ,  Fabrice Bartolomei ,  Maxime Guye

IPC: A61B5/00 ,  G16H50/50 ,  A61B34/10 ,  A61B5/0478 ,  A61B5/291 ,  A61B5/369 ,  G16H10/60

Abstract: The method of modulating epileptogenicity in a brain of an epileptic patient includes: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading the model in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in the data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing the at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.

公开(公告)号：US20210340163A1

公开(公告)日：2021-11-04

申请号：US15777365

申请日：2016-11-08

Applicant: UNIVERSITE D'AIX MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

Inventor： Elena ZABOROVA ,  Frédéric FAGES ,  Anthony D'ALEO

IPC: C07F5/02

Abstract: The present invention relates to new borondifluoride complexes of curcuminoid compounds with an enhanced fluorescence quantum yield and emission, and their uses as fluorophore in various fields such as bioimaging, therapeutics, theranostics, display and telecommunication technologies, photovoltaics. The preparation said compounds is also described.

公开(公告)号：US11004220B2

公开(公告)日：2021-05-11

申请号：US16626762

申请日：2018-07-10

Applicant: Universite d'Aix Marseille ,  Centre National de la Recherche Scientifique

Inventor： Arnaud Le Troter ,  David Ben Dahan ,  Augustin Ogier

IPC: G06T7/38 ,  G06T7/11

Abstract: This method (100) for automatic propagation into an (N+1)-th dimension of an image segmentation initialized in dimension N, N≥2, comprises the acquisition (102) of an ordered series of image representations of dimension N and an initial segmentation (104) in dimension N of a region of interest in the first and last image representations of the series, to obtain first and last initial segmentation masks (M0, Mn) of the region of interest.
It further comprises an estimation (106) of registration parameters (La, Ld) between the first and last initial segmentation masks, and upward and downward automatic propagations (108) of the initial segmentation, from the first and last image representations, to all the other image representations of the series by step-by-step registration up to the last and first image representations. The upward and downward automatic propagations are then combined with one another (110, 112) using a reference frame change, between the first and last image representations, obtained by applying the estimated registration parameters (La, Ld).

公开(公告)号：US10948611B2

公开(公告)日：2021-03-16

申请号：US15981321

申请日：2018-05-16

Applicant: STMicroelectronics (Crolles 2) SAS ,  Centre National De La Recherche Scientifique ,  UNIVERSITE D'AIX MARSEILLE ,  UNIVERSITE DE TOULON

Inventor： Martin Cochet ,  Dimitri Soussan ,  Fady Abouzeid ,  Gilles Gasiot ,  Philippe Roche

IPC: G01T1/02 ,  H03K3/03

Abstract: Absorbed ionizing particles differentially effect first and second acquiring circuit stages configured to respectively generate first and second acquisition signals. Each acquisition signal has a characteristic that is variable as a function of an amount of absorbed ionizing particles. A measuring circuit generates, on the basis of the first and second acquisition signals, a relative parameter indicative of a relationship between the variable characteristics. A computation of a total ionizing dose is made using a 1st- or 2nd-degree polynomial relationship in the relative parameter.

公开(公告)号：US20210038682A1

公开(公告)日：2021-02-11

申请号：US16980334

申请日：2019-03-13

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE D'AIX-MARSEILLE (AMU)

Inventor： Brahim Tighilet ,  Christian Chabbert ,  Christiane Mourre ,  David Pericat ,  Jacques Léonard

IPC: A61K38/12 ,  A61P1/08

Abstract: The invention relates to a modulator of small conductance calcium activated K+ channels of the vestibular nuclei cells for use in the treatment of a lesional vestibular disorder in a patient in need thereof, and to a pharmaceutical composition comprising such modulator, for such a use.

公开(公告)号：US20200218147A1

公开(公告)日：2020-07-09

申请号：US16494607

申请日：2018-03-08

Applicant: UNIVERSITE D'AIX-MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  SORBONNE UNIVERSITE ,  UNIVERSITE PARIS-SUD

Inventor： David GROSSO ,  Marco FAUSTINI ,  Olivier DALSTEIN ,  Andréa CATTONI ,  Thomas BOTTEIN

IPC: G03F7/00 ,  B22D21/00

Abstract: The present invention pertains to the field of nanoimprint lithography (NIL) processes and more specifically to a soft NIL process used for providing a sol-gel patterned layer on a substrate. Specifically, this process comprises a step of adjusting the solvent uptake of the sol-gel film to 10 to 50% vol., preferably between 15 and 40% vol., by varying the relative pressure of the solvent while a soft mould is applied onto the substrate coated with the sol-gel film.

公开(公告)号：US10562842B2

公开(公告)日：2020-02-18

申请号：US15279771

申请日：2016-09-29

Applicant: UNIVERSITE D'AIX-MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE CORSE

Inventor： Jean-Michel Bolla ,  Jean Michel Brunel ,  Joseph Pierre Felix Casanova ,  Vannina Lorenzi ,  Liliane Berti

IPC: A61K31/132 ,  C07C211/22 ,  A61K31/16 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4375 ,  A61K31/495 ,  A61K31/5375 ,  A61K45/06 ,  C07C211/21 ,  C07C233/38 ,  C07D207/27 ,  C07D295/13 ,  A01N33/02 ,  A01N37/18 ,  A01N43/36 ,  A01N43/60 ,  A01N43/84 ,  A23L3/3526 ,  A61K8/41 ,  A61K8/42 ,  A61K8/49 ,  A61K31/131 ,  A61K31/165 ,  A61K31/431 ,  A61K31/546 ,  A61K31/65 ,  A61K31/7048 ,  C07D295/15

Abstract: The present invention relates to the use of polyaminoisoprenyl derivatives in antibiotic or antiseptic treatment of bacteria including those presenting multiple drug resistance (MDR), in particular as efflux pump inhibitors. It also relates to novel polyaminoisoprenyl derivatives, compositions comprising the same, process for preparing the same, and use thereof in antibiotic or antiseptic treatment.

公开(公告)号：US20190351079A1

公开(公告)日：2019-11-21

申请号：US16479234

申请日：2018-01-30

Applicant: VECT-HORUS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'AIX-MARSEILLE

Inventor： CÉDRIC MALICET ,  PASCALINE LECORCHE ,  JONATHAN NOWAK ,  MARION DAVID ,  JAMAL TEMSAMANI ,  MICHEL KHRESTCHATISKY

IPC: A61K51/08 ,  A61K51/04 ,  C07K7/06 ,  G01N33/60 ,  G01N33/574 ,  G01N33/92

Abstract: The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.

公开(公告)号：US20190315866A1

公开(公告)日：2019-10-17

申请号：US16452984

申请日：2019-06-26

Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  INSTITUT JEAN PAOLI & IRENE CALMETTES ,  UNIVERSITE D'AIX-MARSEILLE ,  Universite Claude Bernard - Lyon 1 ,  Centre Leon Berard

Inventor： Julien Faget ,  Christophe Caux ,  Christine Menetrier-Caux ,  Jacques Nunes ,  Daniel Olive

IPC: C07K16/28 ,  G01N33/574 ,  G01N33/569

Abstract: The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-O and IFNγ production, induce CD4− T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

公开(公告)号：US10421725B2

公开(公告)日：2019-09-24

申请号：US14897600

申请日：2014-06-13

Applicant: Centre National De La Recherche Scientifique ,  Universite d'Aix Marseille ,  Universite de Bordeaux

Inventor： Philippe Mellet ,  Sylvain Marque ,  Jean-Michel Franconi ,  Pierre Voisin ,  Damien Moncelet ,  Paul Bremond ,  Gérard Audran

IPC: A61K9/00 ,  C07D213/30 ,  C07C239/20 ,  A61K49/06 ,  A61B5/055 ,  A61B5/00 ,  C07F9/58

Abstract: The present invention relates to alkoxyamines of general formula (I), and to compounds of general formula (IIa), (IIb), (IIc), (IId), IIe), (IIf) or (IIg), as such and for the treatment of cancers.