公开(公告)号：US20220291233A1

公开(公告)日：2022-09-15

申请号：US17627953

申请日：2020-06-30

Applicant: Universiteit Antwerpen

Inventor： Annemieke Smet ,  Benedicte De Winter ,  Tom Breugelmans

IPC: G01N33/68 ,  C12Q1/6883

Abstract: The present invention relates to the field of mucin isoforms, more in particular for use in the diagnosis, monitoring, prevention and/or treatment of a disease characterized by barrier dysfunction, such as but not limited to a gastrointestinal disorder (e.g. Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), cancer, gastro-intestinal infections, obesitas, non-alcoholic fatty liver disease (NAFLD)), neurodegenerative disorders, respiratory infections, . . . In a specific embodiment, said mucin isoform is selected from the list comprising: MUC1 isoforms and MUC13 isoforms.

公开(公告)号：US20220157559A1

公开(公告)日：2022-05-19

申请号：US17431849

申请日：2020-02-25

Applicant: UNIVERSITEIT ANTWERPEN ,  IMEC VZW ,  UNIVERSITEIT GENT

Inventor： Wouter VAN PUTTE ,  Jean-Pierre TIMMERMANS ,  Jan VANFLETEREN

IPC: H01J37/26 ,  B01J19/00

Abstract: An electron microscopy grid, includes: (i) a perforated substrate, (ii) a support film on the perforated substrate, the support film having a thickness of 60 Å or less, and (iii) linkers attached on top of the support film. The linkers has at least one affinity group for immobilizing an analyte; wherein the linkers form a non-random pattern on the support film.

公开(公告)号：US20210184334A1

公开(公告)日：2021-06-17

申请号：US17187128

申请日：2021-02-26

Applicant: IMEC VZW ,  UNIVERSITEIT ANTWERPEN

Inventor： Maarten WEYN ,  Philip Ludovic E SANDERS

IPC: H01Q1/22 ,  H02J50/20 ,  H01Q21/28 ,  H04B5/00

Abstract: A wireless communication device comprises a control unit, an antenna interface, an active wireless transceiver operable together with the control unit and antenna interface, a passive wireless transceiver operable together with the antenna interface and operable by harvesting power from received radio messages. The device is further configured to deactivate the one or more active wireless transceivers and control unit to an inactive state and, subsequently, by the passive wireless transceiver, activate the control unit and an active wireless transceiver to an active state when the passive wireless transceiver receives a message from the antenna interface.

公开(公告)号：US20210130273A1

公开(公告)日：2021-05-06

申请号：US16635795

申请日：2018-08-02

Applicant: Universiteit Antwerpen

Inventor： Bert Maes ,  Jeroen Bomon ,  Serguei Sergueev ,  Enguerrand Blondiaux

IPC: C07C37/055

Abstract: The present invention in general relates to a method for the deacylation and/or dealkylation (both O-dealkylation as well as C-dealkylation) of compounds, more specifically of aromatic compounds. The method is characterized by contacting the compound with an acid-containing aqueous reaction mixture using high temperature and high pressure conditions. The invention also provides a method for preparing a compound suitable for further deacylation using the method of the invention.

公开(公告)号：US20210128648A1

公开(公告)日：2021-05-06

申请号：US16496719

申请日：2018-03-23

Applicant: KU Leuven Research & Development ,  Universiteit Antwerpen

Inventor： Camille Allonsius ,  Ilke De Boeck ,  Stijn Wittouck ,  Sander Wuyts ,  Sarah Lebeer ,  Peter Hellings

IPC: A61K35/747 ,  C12N1/20 ,  A23L33/135

Abstract: The present invention is directed to a novel isolated bacterial strain of the Lactobacillus casei (L. casei) species. More in particular, the strain of the Lactobacillus casei species deposited under accession number LMG P-30039. The present invention further relates to the novel L. casei strain for use in the treatment and/or prevention of infections and/or immune-related diseases. Also the use of the isolated novel L. casei strain or a composition comprising said strain as an adjuvant to promote an immune response during vaccination is disclosed. Further, the use of said novel L. casei strain or a composition comprising said strain in personal hygiene industry, cleaning industry, biomass production, air purification and food industry is disclosed. In another aspect of the present invention, the use of a L. casei species that has a whole genome G/C content of at least 47.5% and expresses one or more catalase genes or a composition comprising one or more of said L. casei species in personal hygiene industry, cleaning industry, biomass production, air purification and food industry is disclosed.

公开(公告)号：US20210094909A1

公开(公告)日：2021-04-01

申请号：US16967871

申请日：2019-02-05

Applicant: VIB VZW ,  Universiteit Antwerpen ,  Universiteit Gent

Inventor： Peter VANDENABEELE ,  Tom VANDEN BERGHE ,  Koen AUGUSTYNS ,  Sam HOFMANS ,  Pieter VAN DER VEKEN ,  Lars DEVISSCHER

IPC: C07C311/39

Abstract: The present invention relates to 3-(benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 (Fer-1) analogues as cell death inhibitors by inhibition of ferroptosis and/or oxytosis for the treatment of stroke, myocardial infarction, diabetes, sepsis, the prevention of transplant rejection, neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, dementia with Lewy bodies and Friedreich's ataxia. The present invention further relates to pharmaceutical compositions of these compounds and discloses methods for making the compounds and the corresponding intermediate.

公开(公告)号：US10481587B2

公开(公告)日：2019-11-19

申请号：US15572328

申请日：2016-05-09

Applicant: Universiteit Antwerpen ,  VZW More Institute

Inventor： Toon Huysmans ,  Jan Jozef Maria Sijbers ,  Frederik Verstreken

IPC: A61F5/01 ,  G05B19/4099 ,  A61F5/02 ,  B33Y80/00 ,  A61B5/107 ,  B33Y50/00 ,  G16H50/50

Abstract: Method for making an orthosis of a body part of a person, wherein the method comprises of: —measuring the body part with a shape and in a pose in order to obtain measurement data of the body part; —correlating the measurement data of the body part to a predetermined statistical shape model of a corresponding reference body part in order to calculate parameters of the statistical shape model; —digitally forming an orthosis model on the basis of the statistical shape model with the known parameters; —producing the orthosis via a CAD/CAM system on the basis of the digitally formed orthosis model.

公开(公告)号：US20190274937A1

公开(公告)日：2019-09-12

申请号：US16347267

申请日：2017-11-03

Applicant: Yun NV ,  Universiteit Antwerpen

Inventor： Tim Henkens ,  Filip Kiekens ,  Sarah Lebeer ,  Ingmar Claes

IPC: A61K8/368 ,  A61K8/37 ,  A61K8/39 ,  A61Q19/10 ,  A61Q19/00

Abstract: The present invention relates to microbiome-safe cosmetic cleaning compositions (i.e. soaps) and uses thereof in preserving the natural microflora of the human or animal skin/vagina. These cleaning compositions may also be beneficially used in combination with topical probiotic therapies, which may be compromised when using classical soaps. In particular, the present invention provides cosmetic cleaning compositions comprising at least one organic acid, as preservative; and at least one glycerol ester as surfactant. For these compositions it was found that they have the typical characteristics of a soap without the negative effects on the natural microflora of the skin/vagina.

公开(公告)号：US10322377B2

公开(公告)日：2019-06-18

申请号：US15120484

申请日：2015-02-24

Applicant: VITO NV ,  UNIVERSITEIT ANTWERPEN

Inventor： Anita Buekenhoudt ,  Kenny Wyns ,  Ghulam Mustafa ,  Vera Meynen

IPC: B01D65/08 ,  B01D61/02 ,  B01D67/00 ,  B01D69/14 ,  B01D71/02 ,  C02F1/44

Abstract: Provided herein are filtration membranes for water treatment, and methods for preventing fouling of such membranes. The method described herein comprises grafting the membrane surface with an organic moiety, by reacting the surface with an organometallic reagent, a phosphonate, a phosphinate, or an organosilane.

公开(公告)号：US20190145912A1

公开(公告)日：2019-05-16

申请号：US16093275

申请日：2017-04-06

Applicant: UNIVERSITEIT ANTWERPEN

Inventor： Jan SIJBERS ,  Jan Jozef Victor DE BEENHOUWER

IPC: G01N23/046 ,  G01V5/00

Abstract: A system for imaging a target object comprises a first unmanned vehicle including a source of penetrating radiation. The first vehicle positions the source such as to direct the radiation toward the target object. A second unmanned vehicle comprises an image detector for registering a spatial distribution of the radiation as an image, in which the second vehicle positions the detector to register the distribution of radiation when transmitted through the target object. These unmanned vehicles are autonomous vehicles adapted for independent propelled motion, and comprise a positioning unit for detecting a position of the vehicle. A processing unit controls the motion of the unmanned vehicles to acquire at least two images corresponding to at least two different projection directions of the radiation through the target object. The processing unit is adapted for generating data representative of an internal structure of the target object from the at least two images.