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公开(公告)号：US10077427B2
公开(公告)日：2018-09-18
申请号：US14669916
申请日：2015-03-26
Inventor： Hergen Spits
IPC: C12N5/06 , C12N5/0781 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/60
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号：US09822339B2
公开(公告)日：2017-11-21
申请号：US14836335
申请日：2015-08-26
Inventor： Hergen Spits , Ferenc A. Scheeren , Tim Beaumont , Sean A. Diehl
IPC: A61K38/00 , C12N15/63 , C12N5/18 , C12N5/0781 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/231 , C12N2501/2321 , C12N2501/52 , C12N2501/60 , C12N2502/99 , C12N2510/02 , C12N2510/04
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号：US20170306293A1
公开(公告)日：2017-10-26
申请号：US15612096
申请日：2017-06-02
Inventor： HERGEN SPITS , FERENC A. SCHEEREN , TIM BEAUMONT , SEAN A. DIEHL
IPC: C12N5/0781 , C07K16/00
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/231 , C12N2501/2321 , C12N2501/52 , C12N2501/60 , C12N2502/99 , C12N2510/02 , C12N2510/04
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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14.发明授权Nickel-based complexes and their use in a process for the transformation of olefins 有权镍基络合物及其在烯烃转化方法中的应用公开(公告)号：US09308528B2
公开(公告)日：2016-04-12
申请号：US14694216
申请日：2015-04-23
Applicant: IFP Energies Nouvelles , UNIVERSITEIT VAN AMSTERDAM
Inventor： Pierre Boulens , Pierre-Alain Breuil , Joost Reek , Helene Olivier-Bourbigou
CPC classification number: B01J31/2295 , B01J31/188 , B01J31/24 , B01J2231/20 , B01J2531/847 , B01J2540/30 , C07C2/34 , C07C2531/22 , C07F15/04
Abstract: The invention describes a novel type of nickel-based complex and its preparation method. The invention also concerns the use of said complex in a process for the transformation of olefins.
Abstract translation: 本发明描述了一种新型的镍基络合物及其制备方法。 本发明还涉及所述络合物在烯烃转化方法中的用途。
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15.发明申请公开(公告)号：US20160060598A1
公开(公告)日：2016-03-03
申请号：US14836335
申请日：2015-08-26
Inventor： Hergen Spits , Ferenc A. Scheeren , Tim Beaumont , Sean A. Diehl
IPC: C12N5/0781
CPC classification number: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/231 , C12N2501/2321 , C12N2501/52 , C12N2501/60 , C12N2502/99 , C12N2510/02 , C12N2510/04
Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
Abstract translation: 本发明提供了影响抗体产生细胞的稳定性的方法，其包括直接或间接地影响所述抗体产生细胞内的BCL6和/或Blimp1表达产物的量。 还提供稳定的抗体产生细胞和细胞系，以及使用这种细胞和/或细胞系产生抗体的方法。
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Patent Agency Ranking
16.发明申请NOVEL CYCLIC NICKEL-BASED COMPLEXES AND THEIR USE IN A PROCESS FOR THE TRANSFORMATION OF OLEFINS 有权新型循环镍基复合物及其在烯烃转化过程中的应用公开(公告)号：US20150307537A1
公开(公告)日：2015-10-29
申请号：US14698500
申请日：2015-04-28
Applicant: IFP Energies nouvelles , Universiteit Van Amsterdam
Inventor： Pierre BOULENS , Pierre-Alain BREUIL , Joost REEK , Helene OLIVIER-BOURBIGOU
IPC: C07F15/04 , C07C211/65 , C07F9/28 , C07C2/32 , B01J31/18
CPC classification number: C07F15/045 , B01J31/1845 , B01J31/188 , B01J31/2247 , B01J31/2256 , B01J31/24 , B01J2231/20 , B01J2531/0213 , B01J2531/847 , C07C2/32 , C07C211/65 , C07C2531/22 , C07F9/28
Abstract: The invention describes a novel type of nickel-based complex and its preparation method. The invention also concerns the use of said complex in a process for the transformation of olefins.
Abstract translation: 本发明描述了一种新型的镍基络合物及其制备方法。 本发明还涉及所述络合物在烯烃转化方法中的用途。
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17.发明申请Mammography Apparatus and Method to Adjust or Tune the Mechanical Settings of Such a Mammography Apparatus 有权用于调整或调节这种乳房X线摄影装置的机械设置的乳房摄影装置和方法公开(公告)号：US20150043711A1
公开(公告)日：2015-02-12
申请号：US14524806
申请日：2014-10-27
CPC classification number: A61B6/502 , A61B6/04 , A61B6/0407 , A61B6/0414 , A61B6/10 , A61B90/17 , A61B2090/033 , A61B2090/034 , A61B2090/036 , A61B2090/064 , A61B2090/065 , A61B2576/02 , F04C2270/041 , G01G19/00 , G01G19/52 , H05G1/02
Abstract: A method to adjust or tune mechanical settings of a mammography apparatus comprising an x-ray source, a paddle and a detector with a detector cover, wherein before executing an x-ray measurement a patient's breast is placed and compressed between the detector cover and the paddle, wherein prior to the x-ray measurement reaction forces between the mammography apparatus and the patient's breast are minimized. The invention relates further to a mammography apparatus comprising an x-ray source, a paddle and a detector with a detector cover, which apparatus is provided with at least one weighing means to measure the downwards forces exerted by (the part of) the apparatus above the weighing means towards the ground.
Abstract translation: 一种用于调整或调整包括X射线源，桨和具有检测器盖的检测器的乳房X线照相术设备的机械设置的方法，其中在执行X射线测量之前，将患者的乳房放置并压缩在检测器盖和 桨，其中在x射线测量之前，乳房X线照相术装置和患者乳房之间的反作用力最小化。 本发明进一步涉及包括X射线源，桨和具有检测器盖的检测器的乳房X线照相术装置，该装置设置有至少一个称重装置，以测量上述装置（的一部分）施加的向下的力 称重装置朝向地面。
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公开(公告)号：US20150005403A1
公开(公告)日：2015-01-01
申请号：US14378770
申请日：2013-02-18
Applicant: Universiteit Van Amsterdam
Inventor： Gad Rothenberg , Albert Hendrikus Alberts
IPC: C08J9/228
CPC classification number: C08J9/228 , C08G63/12 , C08J9/02 , C08J9/34 , C08J2205/046 , C08J2205/052 , C08J2300/16 , C08J2367/00
Abstract: The invention pertains to a process for manufacturing a glycerol-tricarboxylic acid polyester foam which comprises the steps of combining glycerol and a tri-carboxylic acid to provide a liquid reaction mixture and contacting the reaction mixture with a substrate under polymerization conditions, wherein the substrate has a top layer comprising one or more of metal, metal oxide, and metal halide. The invention also pertains to a glycerol-tricarboxylic polyester foam, in particular a glycerol-citric acid polyester foam, which has a closed cell foam structure wherein at least 90 vol. % of the foam, preferably at least 95% of the foam, is built up from cells having a diameter below 2 mm. The foamed polyester of the present invention is “green”, biodegradable, and non-toxic, and can be cleanly combusted. It finds application in, int. al., packaging materials, insulation materials, and materials with a short life cycle.
Abstract translation: 本发明涉及一种制备甘油三羧酸聚酯泡沫的方法，其包括将甘油和三羧酸组合以提供液体反应混合物并在聚合条件下使反应混合物与基材接触的步骤，其中基材具有 包括金属，金属氧化物和金属卤化物中的一种或多种的顶层。 本发明还涉及甘油 - 三羧酸聚酯泡沫，特别是甘油 - 柠檬酸聚酯泡沫，其具有闭孔泡沫结构，其中至少90体积％ 泡沫的百分比，优选至少95％的泡沫是由直径小于2mm的细胞构成的。 本发明的发泡聚酯是“绿色”，可生物降解和无毒，并且可以被干净地燃烧。 它在int中找到应用程序。 包装材料，绝缘材料和生命周期短的材料。
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19.发明公开公开(公告)号：US20240003809A1
公开(公告)日：2024-01-04
申请号：US18038590
申请日：2021-10-12
Applicant: STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN , ASML NETHERLAND B.V. , UNIVERSITEIT VAN AMSTERDAM
Inventor： Peter Michael KRAUS , Sylvianne Dorothea Christina ROSCAM ABBING , Filippo CAMPI , ZhuangYan ZHANG , Petrus Wilhelmus SMORENBURG , Nan LIN , Stefan Michiel WITTE , Arie Jeffrey DEN BOEF
CPC classification number: G01N21/4788 , G01B11/0608 , G03F7/70625 , G03F7/706851 , G01N2201/0634
Abstract: Disclosed is a metrology apparatus and method for measurement of a diffractive structure on a substrate. The metrology apparatus comprises a radiation source operable to provide first radiation for excitation of the diffractive structure such that high harmonic second radiation is generated from said diffractive structure and/or substrate; and a detection arrangement operable to detect said second radiation, at least a portion of which having been diffracted by said diffractive structure.
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公开(公告)号：US11771028B2
公开(公告)日：2023-10-03
申请号：US17253816
申请日：2019-06-21
Inventor： Robert Baard , Wishwas Abhyankar , Stanley Brul
Abstract: The present invention relates to a liquid composition comprising living green microalgae for improving plant growth. The liquid composition is prepared by growing green microalgae at a pH of 10-12 in the presence of hydrogen carbonate as the inorganic carbon source. The liquid composition may be stored at 4 to 25 degrees C. until use. The liquid composition may be used to improve fertilizers.
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