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公开(公告)号:US20210330736A1
公开(公告)日:2021-10-28
申请号:US17271978
申请日:2019-09-05
IPC分类号: A61K38/10 , A61K31/52 , A61K31/53 , A61K31/522 , A61K31/404 , A61K31/437 , A61K31/519 , C07K7/08 , A61P25/28
摘要: In embodiments the invention relates to means and methods for the treatment of Parkinson's disease. In some embodiments the means and methods involve a PDE2 inhibitor, a PDE11 inhibitor or a combination thereof, optionally together with a GUCY2C agonist.
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公开(公告)号:US10774308B2
公开(公告)日:2020-09-15
申请号:US16114483
申请日:2018-08-28
发明人: Hergen Spits
IPC分类号: A61K38/00 , C07K16/00 , C12N5/18 , C12N5/0781
摘要: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号:US20200239516A1
公开(公告)日:2020-07-30
申请号:US16467138
申请日:2017-12-06
发明人: Gaston Julia Johannes Richelle , Dieuwertje Emma Streefkerk , Jan Herman van Maarseveen , Peter Timmerman
摘要: The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.
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公开(公告)号:US20200009213A1
公开(公告)日:2020-01-09
申请号:US16490192
申请日:2018-03-02
摘要: In embodiments the invention relates to means and methods for the treatment of Parkinson's disease. In some embodiments the means and methods involve a GUCY2C agonist. The invention also relates to test systems and cells that are suited to identify new candidate compounds for the treatment of Parkinson's disease.
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公开(公告)号:US20180371410A1
公开(公告)日:2018-12-27
申请号:US16114483
申请日:2018-08-28
发明人: Hergen SPITS
IPC分类号: C12N5/0781 , C07K16/00
CPC分类号: C12N5/0635 , C07K16/00 , C12N2501/23 , C12N2501/60
摘要: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.
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公开(公告)号:US09826950B2
公开(公告)日:2017-11-28
申请号:US14524806
申请日:2014-10-27
CPC分类号: A61B6/502 , A61B6/04 , A61B6/0407 , A61B6/0414 , A61B6/10 , A61B90/17 , A61B2090/033 , A61B2090/034 , A61B2090/036 , A61B2090/064 , A61B2090/065 , A61B2576/02 , F04C2270/041 , G01G19/00 , G01G19/52 , H05G1/02
摘要: A method to adjust or tune mechanical settings of a mammography apparatus comprising an x-ray source, a paddle and a detector with a detector cover, wherein before executing an x-ray measurement a patient's breast is placed and compressed between the detector cover and the paddle, wherein prior to the x-ray measurement reaction forces between the mammography apparatus and the patient's breast are minimized. The invention relates further to a mammography apparatus comprising an x-ray source, a paddle and a detector with a detector cover, which apparatus is provided with at least one weighing means to measure the downwards forces exerted by (the part of) the apparatus above the weighing means towards the ground.
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公开(公告)号:US20210171413A1
公开(公告)日:2021-06-10
申请号:US17253816
申请日:2019-06-21
发明人: Robert BAARD , Wishwas ABHYANKAR , Stanley BRUL
摘要: The present invention relates to a liquid composition comprising living green microalgae for improving plant growth. The liquid composition is prepared by growing green microalgae at a pH of 10-12 in the presence of hydrogen carbonate as the inorganic carbon source. The liquid composition may be stored at 4 to 25 degrees C. until use. The liquid composition may be used to improve fertilizers.
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8.
公开(公告)号:US20200232931A1
公开(公告)日:2020-07-23
申请号:US16751104
申请日:2020-01-23
申请人: ASML Netherlands B.V. , Stichting Nederlandse Wetenschappelijk Onderzoek Instituten , Stichting VU , Universiteit van Amsterdam
发明人: Stefan Michiel WITTE , Gijsbert Simon Matthijs JANSEN , Lars Christian FREISEM , Kjeld Sijbrand Eduard EIKEMA , Simon Gijsbert Josephus MATHIJSSEN
摘要: A metrology apparatus (302) includes a higher harmonic generation (HHG) radiation source for generating (310) EUV radiation. Operation of the HHG source is monitored using a wavefront sensor (420) which comprises an aperture array (424, 702) and an image sensor (426). A grating (706) disperses the radiation passing through each aperture so that the image detector captures positions and intensities of higher diffraction orders for different spectral components and different locations across the beam. In this way, the wavefront sensor can be arranged to measure a wavefront tilt for multiple harmonics at each location in said array. In one embodiment, the apertures are divided into two subsets (A) and (B), the gratings (706) of each subset having a different direction of dispersion. The spectrally resolved wavefront information (430) is used in feedback control (432) to stabilize operation of the HGG source, and/or to improve accuracy of metrology results.
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9.
公开(公告)号:US20190107781A1
公开(公告)日:2019-04-11
申请号:US16150879
申请日:2018-10-03
申请人: Stichting VU , Stichting Nederlandse Wetenschappelijk Onderzoek Instituten , Universiteit van Amsterdam , ASML Netherlands B.V.
发明人: Patricius Aloysius Jacobus TINNEMANS , Arie Jeffrey Den Boef , Armand Eugene Albert Koolen , Nitesh Pandey , Vasco Tomas Tenner , Willem Marie Julia Marcel Coene , Patrick Warnaar
摘要: Described is a metrology system for determining a characteristic of interest relating to at least one structure on a substrate, and associated method. The metrology system comprises a processor being configured to computationally determine phase and amplitude information from a detected characteristic of scattered radiation having been reflected or scattered by the at least one structure as a result of illumination of said at least one structure with illumination radiation in a measurement acquisition, and use the determined phase and amplitude to determine the characteristic of interest.
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公开(公告)号:US20170269482A1
公开(公告)日:2017-09-21
申请号:US15453049
申请日:2017-03-08
申请人: Stichting VU , Universiteit van Amsterdam , Stichting voor Fundamenteel Onderzoek der Materie , ASML Netherlands B.V.
IPC分类号: G03F7/20 , G01B11/00 , G01N21/956 , G01N21/47
CPC分类号: G03F7/7065 , G01B11/00 , G01N21/4788 , G01N21/956 , G01N2201/061 , G01N2201/0635 , G02B21/16 , G03F7/70625 , G03F7/70633 , H05G2/003 , H05G2/008
摘要: In an inspection apparatus, a target on the surface is illuminated with illuminating radiation that comprises first and second illuminating components. The illuminating components form one or more periodic illuminating patterns on the surface. A plurality of scattered radiation patterns formed by the illuminating radiation after scattering by the target is captured at a detector for a number of values of a controllable characteristic of at least one of the illuminating components. The captured radiation is then used to reconstruct data describing the target.
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