公开(公告)号：US20210330736A1

公开(公告)日：2021-10-28

申请号：US17271978

申请日：2019-09-05

Applicant: UNIVERSITEIT VAN AMSTERDAM

Inventor： Marten Piet SMIDT ,  Lars Philip VAN DER HEIDE

IPC: A61K38/10 ,  A61K31/52 ,  A61K31/53 ,  A61K31/522 ,  A61K31/404 ,  A61K31/437 ,  A61K31/519 ,  C07K7/08 ,  A61P25/28

Abstract: In embodiments the invention relates to means and methods for the treatment of Parkinson's disease. In some embodiments the means and methods involve a PDE2 inhibitor, a PDE11 inhibitor or a combination thereof, optionally together with a GUCY2C agonist.

公开(公告)号：US10774308B2

公开(公告)日：2020-09-15

申请号：US16114483

申请日：2018-08-28

Applicant: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ,  AIMM THERAPEUTICS B.V.

Inventor： Hergen Spits

IPC: A61K38/00 ,  C07K16/00 ,  C12N5/18 ,  C12N5/0781

Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.

公开(公告)号：US20200239516A1

公开(公告)日：2020-07-30

申请号：US16467138

申请日：2017-12-06

Applicant: Stichting voor de Technische Wetenschappen ,  Universiteit van Amsterdam

Inventor： Gaston Julia Johannes Richelle ,  Dieuwertje Emma Streefkerk ,  Jan Herman van Maarseveen ,  Peter Timmerman

IPC: C07K1/04 ,  C07K1/107 ,  C07K7/56 ,  C07K7/64 ,  C40B30/04 ,  G01N33/543

Abstract: The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

公开(公告)号：US20200009213A1

公开(公告)日：2020-01-09

申请号：US16490192

申请日：2018-03-02

Applicant: Universiteit van Amsterdam

Inventor： Lars Philip van der Heide

IPC: A61K38/10 ,  A61P25/16 ,  A61K31/522 ,  C12N9/88 ,  C12N9/02 ,  G01N33/50

Abstract: In embodiments the invention relates to means and methods for the treatment of Parkinson's disease. In some embodiments the means and methods involve a GUCY2C agonist. The invention also relates to test systems and cells that are suited to identify new candidate compounds for the treatment of Parkinson's disease.

公开(公告)号：US20180371410A1

公开(公告)日：2018-12-27

申请号：US16114483

申请日：2018-08-28

Applicant: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ,  AIMM THERAPEUTICS B.V.

Inventor： Hergen SPITS

IPC: C12N5/0781 ,  C07K16/00

CPC classification number: C12N5/0635 ,  C07K16/00 ,  C12N2501/23 ,  C12N2501/60

Abstract: The invention provides a method for influencing the stability of an antibody producing cell, comprising directly or indirectly influencing the amount of BCL6 and/or Blimp 1 expression product within said antibody producing cell. Stable antibody producing cells and cell lines are also provided, as well as methods for producing antibodies using such cells and/or cell lines.

公开(公告)号：US09826950B2

公开(公告)日：2017-11-28

申请号：US14524806

申请日：2014-10-27

Applicant: Academisch Medisch Centrum bij de Universiteit van Amsterdam

Inventor： Gerardus Johannes Den Heeten ,  Cornelis Antonius Grimbergen ,  Christiaan Neeleman

IPC: A61B6/04 ,  A61B6/10 ,  H05G1/02 ,  A61B6/00 ,  A61B90/17 ,  A61B90/00 ,  G01G19/52 ,  G01G19/00

CPC classification number: A61B6/502 ,  A61B6/04 ,  A61B6/0407 ,  A61B6/0414 ,  A61B6/10 ,  A61B90/17 ,  A61B2090/033 ,  A61B2090/034 ,  A61B2090/036 ,  A61B2090/064 ,  A61B2090/065 ,  A61B2576/02 ,  F04C2270/041 ,  G01G19/00 ,  G01G19/52 ,  H05G1/02

Abstract: A method to adjust or tune mechanical settings of a mammography apparatus comprising an x-ray source, a paddle and a detector with a detector cover, wherein before executing an x-ray measurement a patient's breast is placed and compressed between the detector cover and the paddle, wherein prior to the x-ray measurement reaction forces between the mammography apparatus and the patient's breast are minimized. The invention relates further to a mammography apparatus comprising an x-ray source, a paddle and a detector with a detector cover, which apparatus is provided with at least one weighing means to measure the downwards forces exerted by (the part of) the apparatus above the weighing means towards the ground.

公开(公告)号：US20220088853A1

公开(公告)日：2022-03-24

申请号：US17604870

申请日：2020-04-20

Applicant: UNIVERSITEIT VAN AMSTERDAM

Inventor： Suhas NAWADA

IPC: B29C64/129 ,  B33Y30/00 ,  B33Y10/00 ,  B29C64/286

Abstract: The invention provides a stereo lithographic 3D printing assembly comprising a digital projection system for projecting a first pattern having a first resolution at a projection location, and a photo mask system for projecting a second pattern having a second resolution at said projection location.
This provides a fast 3D printing assembly allowing high resolution details.

公开(公告)号：US11192918B2

公开(公告)日：2021-12-07

申请号：US16467138

申请日：2017-12-06

Applicant: Universiteit van Amsterdam ,  Stichting voor de Technische Wetenschappen

Inventor： Gaston Julia Johannes Richelle ,  Dieuwertje Emma Streefkerk ,  Jan Herman van Maarseveen ,  Peter Timmerman

IPC: C07K1/107 ,  C07K1/04 ,  C07K7/56 ,  C07K7/64 ,  C40B30/04 ,  G01N33/543

Abstract: The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

公开(公告)号：US20190265028A1

公开(公告)日：2019-08-29

申请号：US16277317

申请日：2019-02-15

Applicant: Stichting VU ,  Stichting Nederlandse Wetenschappelijk Onderzoek Instituten ,  Universiteit van Amsterdam ,  ASML Netherlands B.V.

Inventor： Patricius Aloysius Jacobus TINNEMANS ,  Vasco Tomas Tenner ,  Arie Jeffrey Den Boef ,  Hugo Augustinus Joseph Cramer ,  Patrick Warnaar ,  Grzegorz Grzela ,  Martin Jacobus Johan Jak

IPC: G01B11/25 ,  G03F7/20

Abstract: Disclosed is a method and associated apparatus for measuring a characteristic of interest relating to a structure on a substrate. The method comprises calculating a value for the characteristic of interest directly from the effect of the characteristic of interest on at least the phase of illuminating radiation when scattered by the structure, subsequent to illuminating said structure with said illuminating radiation.

公开(公告)号：US20180374700A1

公开(公告)日：2018-12-27

申请号：US16064613

申请日：2016-12-22

Applicant: UNIVERSITEIT VAN AMSTERDAM

Inventor： Emanuele MARINO ,  Thomas Edward KODGER ,  Peter SCHALL

IPC: H01L21/02 ,  C01B19/00 ,  C30B29/48 ,  C30B33/06

Abstract: A method for assembling semiconductor nanocrystals including: providing a binary system including semiconductor nanocrystals with an effective particle diameter of at most 20 nm, a first and a second solvent, the system having: a Ta, which is the temperature at which aggregation starts, a Ts, which is the solvent separation temperature of the system, an aggregation temperature range between Ta and Ts with Ta being included and Ts not, a homogeneous temperature range which is below Ta when Ta is lower than Ts and which is above Ta when Ta is higher than Ts, a heterogeneous temperature range which is above Ts when Ta is lower than Ts and below Ts when Ta is higher than Ts, and, bringing the temperature of the binary system from a value in the homogeneous temperature range to a value in the aggregation temperature range, thereby causing formation of an aggregate of the nanocrystals.