公开(公告)号：US20040253686A1

公开(公告)日：2004-12-16

申请号：US10680684

申请日：2003-10-07

Applicant: ZymoGenetics, Inc. ,  The University of New Mexico

Inventor： Cindy A. Sprecher ,  Walt Kisiel ,  Donald C. Foster

IPC: C12N009/99 ,  C07H021/04

CPC classification number: C07K14/8114 ,  A61K38/00

Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.

Abstract translation: 本发明提供了分离的DNA分子，其包含编码新型人Kunitz型抑制剂的DNA区段。 还提供了包含编码新型人Kunitz型抑制剂的第一DNA区段的DNA构建体，其中所述第一DNA区段可操作地连接到第一DNA区段的表达所需的另外的DNA区段，以及含有这种DNA构建体的宿主细胞， 从宿主细胞产生蛋白质的方法。

公开(公告)号：US20040110680A1

公开(公告)日：2004-06-10

申请号：US10636968

申请日：2003-08-08

Applicant: Regents of the University of New Mexico

Inventor： Galen D. Knight ,  Paul L. Mann ,  Terence J. Scallen

IPC: C12Q001/68 ,  A61K038/17

CPC classification number: A61K31/16 ,  C12N2501/999

Abstract: null-alethine is employed in the differentiation, phenotypic expression, and vitalization of cells, for both in vivo and in vitro applications. Particular applications include the use of null-alethine in the treatment of immune disorders and diseases, and in the promotion of cell cultures.

Abstract translation: β-alethine用于细胞的分化，表型表达和活化，用于体内和体外应用。 具体应用包括使用β-alethine治疗免疫疾病和疾病，以及促进细胞培养。

公开(公告)号：US20040082020A1

公开(公告)日：2004-04-29

申请号：US10616323

申请日：2003-07-09

Applicant: University of New Mexico

Inventor： Laurence A. Cole

IPC: G01N033/574

CPC classification number: G01N33/57442 ,  G01N33/74 ,  G01N33/76

Abstract: The invention provides methods for detecting the presence or absence of invasive trophoblast cells. In addition, the invention provides methods for distinguishing quiescent trophoblast diseases from invasive trophoblast diseases and methods for monitoring progression of quiescent trophoblast diseases. The invention provides methods for detecting the presence or absence of germ cell tumors.

Abstract translation: 本发明提供了用于检测侵入性滋养细胞存在或不存在的方法。 此外，本发明提供了将静止滋养层疾病与侵入性滋养层疾病区分开来的方法以及监测静息滋养层疾病进展的方法。 本发明提供了用于检测生殖细胞肿瘤的存在或不存在的方法。

公开(公告)号：US10903035B2

公开(公告)日：2021-01-26

申请号：US15918159

申请日：2018-03-12

Applicant: Wisconsin Alumni Research Foundation ,  University of New Mexico

Inventor： Daniel W. van der Weide ,  Max Lagally ,  Francesca Cavallo

IPC: H01J25/02

Abstract: A self-assembling element fabricated using integrated circuit techniques may provide a small diameter helical conductor surrounding an electron beam for the construction of a vacuum electronic device such as a traveling-wave tube for terahertz scale signal.

公开(公告)号：US20030191377A1

公开(公告)日：2003-10-09

申请号：US10116269

申请日：2002-04-04

Applicant: InLight Solutions, Inc. ,  University of New Mexico

Inventor： Mark Ries Robinson ,  Cliona Fleming ,  Howland Jones ,  Mark Rohrscheib

IPC: A61B005/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/1495

Abstract: A method is provided for building improved calibration models or for improving modifications to these models or validation of the models used in the non-invasive spectroscopic measurement of an analyte or attribute of tissue. The method uses a matched reference sample and measurement of that sample to ensure that the correct relationship between the spectra and analyte is made during the model building, modification or calibration process. A matched reference sample is one in which the analyte of interest or attribute of interest in the reference sample is representative of the analyte or attribute at the site being non-invasively sampled or the agreement between the reference concentration and the non-invasively sampled concentration is clinically significant.

Abstract translation: 提供了一种用于构建改进的校准模型或改进对这些模型的修改或验证在分析物或组织属性的非侵入性光谱测量中使用的模型的方法。 该方法使用匹配的参考样本和样本的测量，以确保在模型构建，修改或校准过程中进行光谱和分析物之间的正确关系。 匹配的参考样品是其中参考样品中感兴趣的分析物或感兴趣的属性代表分析物或在非侵入性采样的位点处的属性或参考浓度与非侵入采样浓度之间的一致性的样品 临床意义重大

公开(公告)号：US20210202240A1

公开(公告)日：2021-07-01

申请号：US17134783

申请日：2020-12-28

Applicant: Wisconsin Alumni Research Foundation ,  The Regents of the University of New Mexico

Inventor： Max G. Lagally ,  Francesca Cavallo ,  Vijay Saradhi Mangu

IPC: H01L21/02 ,  H01L29/16 ,  H01L27/088 ,  H01L21/8258 ,  G02B5/30 ,  H01L21/3065 ,  H01L21/027

Abstract: Methods for fabricating thin, high-aspect-ratio Ge nanostructures from high-quality, single-crystalline Ge substrates are provided. Also provided are grating structures made using the methods. The methods utilize a thin layer of graphene between a surface of a Ge substrate, and an overlying resist layer. The graphene passivates the surface, preventing the formation of water-soluble native Ge oxides that can result in the lift-off of the resist during the development of the resist.

公开(公告)号：US10320149B2

公开(公告)日：2019-06-11

申请号：US15741230

申请日：2016-06-29

Applicant: INSTITUT MINES-TELECOM ,  UNIVERSITY OF NEW MEXICO

Inventor： Marek Osinski ,  Frédéric Grillot

IPC: H01S5/10 ,  H01S5/06 ,  H01S5/14 ,  H01S5/022 ,  H01S5/068 ,  H01S5/125 ,  H01S5/343 ,  H01S5/02

Abstract: The invention concerns a wavelength tunable semiconductor laser comprising a laser gain section (510) optically coupled to an underlying optical waveguide (520). According to an embodiment of the invention, a first and a second passive microring resonators (530, 560) having a whistle geometry, are arranged on both sides of the laser gain section and evanescently coupled with the optical waveguide (520). Highly reflective broadband mirrors (541, 571) are provided at the free ends of optical waveguide branches (240, 270) tangentially connected to the microring resonators. The first and second passive microrings resonators provide an optical feedback to the laser gain section and allow to select the desired wavelength. The laser structure can be implemented according to a III-V/Si technology.