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公开(公告)号：US07769449B2
公开(公告)日：2010-08-03
申请号：US11257715
申请日：2005-10-25
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/365
摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.
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公开(公告)号：US20100114230A1
公开(公告)日：2010-05-06
申请号：US12263423
申请日：2008-10-31
申请人： Sarah A. Audit , James K. Carney , William J. Combs , Tommy D. Bennett , Barbro M.L. Kjellstrom
发明人： Sarah A. Audit , James K. Carney , William J. Combs , Tommy D. Bennett , Barbro M.L. Kjellstrom
IPC分类号： A61N1/365
CPC分类号： A61B5/02055 , A61B5/0215 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61N1/36514 , A61N1/36564 , A61N1/37258
摘要： The present disclosure provides an apparatus and method of detecting ischemia with a pressure sensor. The method can include obtaining a pressure signal and determining a pressure rate of change. The method can also include identifying at least one of impaired relaxation and impaired contractility in order to detect ischemia.
摘要翻译： 本公开提供了利用压力传感器检测缺血的装置和方法。 该方法可以包括获得压力信号并确定压力变化率。 该方法还可以包括鉴定减轻的松弛和受损的收缩力中的至少一种以便检测缺血。
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13.发明申请Heart Monitoring Systems, Apparatus and Methods Adapted to Detect Myocardial Ischemia 有权心脏监测系统，适用于检测心肌缺血的装置和方法公开(公告)号：US20080228094A1
公开(公告)日：2008-09-18
申请号：US11684794
申请日：2007-03-12
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0402 , A61B5/721 , A61B5/7475
摘要： Embodiments include heart monitoring systems, apparatus, and methods adapted to detect myocardial ischemia. An apparatus includes at least one first-tier sensor/analyzer adapted to sense a first input related to cardiac function, and to produce a first-tier trigger signal when the first input indicates myocardial ischemia. In an embodiment, a first-tier sensor/analyzer includes an ECG sensor/analyzer. In another embodiment, a first-tier sensor/analyzer includes a patient activator. An apparatus further includes at least one second-tier sensor/analyzer adapted to sense a second input related to cardiac function, and to produce a second-tier trigger signal when the second input indicates myocardial ischemia. In an embodiment, a second-tier sensor-analyzer includes a heart sound sensor/analyzer. A triggering element is adapted to produce a response-invoking signal in response to the first-tier trigger signal and the second-tier trigger signal. The response-invoking signal may invoke a patient alert, a message to an external system, and/or a cardiac stimulus.
摘要翻译： 实施例包括适于检测心肌缺血的心脏监测系统，装置和方法。 一种装置包括适于感测与心脏功能相关的第一输入的至少一个第一层传感器/分析器，以及当第一输入指示心肌缺血时产生第一层触发信号。 在一个实施例中，第一层传感器/分析器包括ECG传感器/分析器。 在另一个实施例中，第一层传感器/分析器包括患者激活器。 装置还包括适于感测与心脏功能相关的第二输入的至少一个第二层传感器/分析器，并且当第二输入指示心肌缺血时产生第二层触发信号。 在一个实施例中，第二层传感器分析仪包括心音传感器/分析器。 触发元件适于响应于第一层触发信号和第二层触发信号产生响应调用信号。 响应调用信号可以调用患者警报，到外部系统的消息和/或心脏刺激。
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公开(公告)号：US06795732B2
公开(公告)日：2004-09-21
申请号：US10002338
申请日：2001-10-30
IPC分类号： A61N1365
CPC分类号： A61N1/36528 , A61B8/00 , A61N1/3627 , A61N1/36578
摘要： Implantable medical devices (IMDs) for detection and measurement of cardiac mechanical and electrical function employ a system and method for determining mechanical heart function and measuring mechanical heart performance of upper and lower and left and right heart chambers without intruding into a left heart chamber through use of a dimension sensor. The dimension sensor or sensors comprise at least a first sonomicrometer piezoelectric crystal mounted to a first lead body implanted into or in relation to one heart chamber that operates as an ultrasound transmitter when a drive signal is applied to it and at least one second sonomicrometer crystal mounted to a second lead body implanted into or in relation to a second heart chamber that operates as an ultrasound receiver.
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15.发明授权Impedance monitor for discerning edema through evaluation of respiratory rate 失效阻抗监测仪通过评估呼吸频率进行辨认性水肿
公开(公告)号：US5957861A
公开(公告)日：1999-09-28
申请号：US791206
申请日：1997-01-31
申请人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrandl
发明人： William J. Combs , Catherine R. Condie , Roy Martin , Dwight H. Warkentin , John D. Wahlstrandl
CPC分类号： A61B5/4878 , A61B5/0535 , A61B5/0809 , A61N1/3702 , A61N1/3627
摘要： An impedance monitor for discerning edema through evaluation of respiratory rate. Preferred embodiment includes edema monitor and trigger to initiate diagnostic reporting or corrective action when activated. Recording of Long Term Average and Short Term Average values for secondary edema measure based on DC signal level are described as are methods and apparatus for removing unwanted recurring noise.
摘要翻译： 通过评估呼吸频率来辨别水肿的阻抗监测仪。 优选实施例包括水肿监测和触发以在被激活时启动诊断报告或纠正动作。 长期平均和短期记录基于直流信号电平的次级水肿测量的平均值被描述为用于消除不期望的重复噪声的方法和装置。
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16.发明授权Heart monitoring systems, apparatus and methods adapted to detect myocardial ischemia 有权适用于检测心肌缺血的心脏监测系统，装置和方法公开(公告)号：US09179852B2
公开(公告)日：2015-11-10
申请号：US11684794
申请日：2007-03-12
IPC分类号： A61B5/04 , A61B5/0452 , A61B5/0402 , A61B5/00
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0402 , A61B5/721 , A61B5/7475
摘要： Embodiments include heart monitoring systems, apparatus, and methods adapted to detect myocardial ischemia. An apparatus includes at least one first-tier sensor/analyzer adapted to sense a first input related to cardiac function, and to produce a first-tier trigger signal when the first input indicates myocardial ischemia. In an embodiment, a first-tier sensor/analyzer includes an ECG sensor/analyzer. In another embodiment, a first-tier sensor/analyzer includes a patient activator. An apparatus further includes at least one second-tier sensor/analyzer adapted to sense a second input related to cardiac function, and to produce a second-tier trigger signal when the second input indicates myocardial ischemia. In an embodiment, a second-tier sensor-analyzer includes a heart sound sensor/analyzer. A triggering element is adapted to produce a response-invoking signal in response to the first-tier trigger signal and the second-tier trigger signal. The response-invoking signal may invoke a patient alert, a message to an external system, and/or a cardiac stimulus.
摘要翻译： 实施例包括适于检测心肌缺血的心脏监测系统，装置和方法。 一种装置包括适于感测与心脏功能相关的第一输入的至少一个第一层传感器/分析器，以及当第一输入指示心肌缺血时产生第一层触发信号。 在一个实施例中，第一层传感器/分析器包括ECG传感器/分析器。 在另一个实施例中，第一层传感器/分析器包括患者激活器。 装置还包括适于感测与心脏功能相关的第二输入的至少一个第二层传感器/分析器，并且当第二输入指示心肌缺血时产生第二层触发信号。 在一个实施例中，第二层传感器分析仪包括心音传感器/分析器。 触发元件适于响应于第一层触发信号和第二层触发信号产生响应调用信号。 响应调用信号可以调用患者警报，到外部系统的消息和/或心脏刺激。
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17.发明授权公开(公告)号：US08498705B2
公开(公告)日：2013-07-30
申请号：US13037780
申请日：2011-03-01
IPC分类号： A61N1/08
CPC分类号： A61N1/368 , A61N1/3682
摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.
摘要翻译： 可植入医疗装置提供心室起搏功能并优化AV间隔用于多种目的。 通常，通过确定何时机电收缩（EMS）结束并相应地设置AV间隔来促进固有传导。 使用包括QT间隔，传感器输入和算法计算的各种数据来确定EMS。
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18.发明授权公开(公告)号：US08200333B2
公开(公告)日：2012-06-12
申请号：US12716038
申请日：2010-03-02
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/365
摘要： An implantable medical device provides ventricular pacing capabilities and optimizes AV intervals for multiple purposes. In general, intrinsic conduction is promoted by determining when electromechanical systole (EMS) ends and setting an AV interval accordingly. EMS is determined utilizing various data including QT interval, sensor input, and algorithmic calculations.
摘要翻译： 可植入医疗装置提供心室起搏功能并优化AV间隔用于多种目的。 通常，通过确定何时机电收缩（EMS）结束并相应地设置AV间隔来促进固有传导。 使用包括QT间隔，传感器输入和算法计算的各种数据来确定EMS。
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公开(公告)号：US07826895B2
公开(公告)日：2010-11-02
申请号：US11460724
申请日：2006-07-28
申请人： Victor Parsonnet , William J. Combs
发明人： Victor Parsonnet , William J. Combs
IPC分类号： A61B5/05
CPC分类号： A61B5/413 , A61B5/0537
摘要： The invention is directed to techniques for monitoring organ rejection. An implanted device monitors the impedance of the transplanted organ. When the impedance measurements indicate that the organ is being rejected, the device provides early warning of rejection.
摘要翻译： 本发明涉及用于监测器官排斥的技术。 植入装置监测移植器官的阻抗。 当阻抗测量表明器官被拒绝时，器件提供拒收的早期警告。
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20.发明申请Comprehensive System for Detection of Coronary Syndrome, Cardiac Ischemia and Myocardial Infarction 审中-公开冠状动脉综合征，心脏缺血和心肌梗死综合检测系统公开(公告)号：US20100023081A1
公开(公告)日：2010-01-28
申请号：US12181247
申请日：2008-07-28
申请人： Sarah Anne Audet , James Kevin Carney , William J. Combs , Eduardo N. Warman , Edward Chinchoy , Thomas J. Mullen , Brian Bruce Lee , Qingshan (Sam) Ye
发明人： Sarah Anne Audet , James Kevin Carney , William J. Combs , Eduardo N. Warman , Edward Chinchoy , Thomas J. Mullen , Brian Bruce Lee , Qingshan (Sam) Ye
IPC分类号： A61N1/365
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/02028 , A61B5/02055 , A61B5/02405 , A61B5/08 , A61B5/11 , A61B5/14532 , A61B5/14539 , A61B5/7275 , A61B7/00 , A61N1/3627 , A61N1/36514
摘要： Heart-monitoring systems, apparatus, and methods adapted to detect CS, CI and/or MI. In one embodiment, a system comprising at least two first-tier sensors capable of measuring and converting into signals at least two aspects related to cardiac function, at least one second-tier sensor that is also a first-tier sensor, at least one signal processor capable of transmitting a first-tier and second-tier trigger signal when coronary syndrome, cardiac ischemia or myocardial infarction has been detected, at least one communication device capable of communicating, at least one control element adapted to produce a first-tier and second-tier trigger signal when at least one first-tier sensor exceeds its threshold signal level, to exclude the signal from the first-tier sensor that exceeded its threshold and lower at least one threshold of the at least one first-tier sensor is provided.
摘要翻译： 适用于检测CS，CI和/或MI的心脏监测系统，装置和方法。 在一个实施例中，一种系统包括至少两个第一层传感器，能够测量和转换成与心脏功能相关的至少两个方面的信号，至少一个第二层传感器，其也是第一层传感器，至少一个信号 处理器能够在冠状动脉综合征，心脏缺血或心肌梗塞已经被检测时发送第一层和第二层触发信号，至少一个能够通信的通信设备，至少一个适于产生第一层和第二层的控制元件 当至少一个第一层传感器超过其阈值信号电平时，将第一层传感器的信号排除超过其阈值并降低至少一个第一层传感器的至少一个阈值。
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