公开(公告)号：US06321122B1

公开(公告)日：2001-11-20

申请号：US09121018

申请日：1998-07-22

Applicant: Avram Scheiner ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  John E. Heil ,  William Hsu ,  Ronald W. Heil, Jr.

Inventor： Avram Scheiner ,  Curtis C. Lindstrom ,  Robert S. Booker, III ,  Yayun Lin ,  Peter T. Kelley ,  John E. Heil ,  William Hsu ,  Ronald W. Heil, Jr.

IPC: A61N100

CPC classification number: A61N1/0573

Abstract: A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The second electrode is adapted for positioning and fixation to the wall of the atrium of the heart. A passive fixation element may be used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and passive fixation of the second electrode.

Abstract translation: 适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统的单程心内膜引导电极包括具有周向外表面的引线体。 引线包括具有第一导电表面的第一远端电极。 引线体还具有具有第二导电表面的第二电极。 第二电极适于定位并固定在心脏心房的壁上。 被动固定元件可以用作第二电极的一部分。 引线体还包括有助于第二电极的定位和被动固定的弯曲部分。

公开(公告)号：US08942791B2

公开(公告)日：2015-01-27

申请号：US13483387

申请日：2012-05-30

Applicant: Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

Inventor： Yanting Dong ,  Shijie Zhang ,  Deepa Mahajan ,  Chenguang Liu ,  Dan Li ,  Yayun Lin ,  Derek D. Bohn

IPC: A61B5/04 ,  A61N1/39

CPC classification number: A61B5/04012 ,  A61B5/0245 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/7217 ,  A61N1/3704 ,  A61N1/3937

Abstract: A system and method for performing independent, off-line evaluation of event sensing for collected electrograms, comprising: sensing an electrogram using an implantable medical device (IMD); determining locations of heart beats on at least one channel of the electrogram using a multi-pass process, resulting in a group of multi-pass beat locations; storing the electrogram and device-identified beat locations in a memory location; and retrieving the electrogram and device-identified beat locations from the memory location. The multi-pass process determines locations of heart beats on at least a first channel of the electrogram. The device-identified group of beat locations are then compared to the multi-pass group of beat locations identified using the multi-pass method. Based on the comparing step, oversensing of beats, undersensing of beats, or noise from the device can be detected.

Abstract translation: 一种用于对收集的电描记图执行事件感测的独立离线评估的系统和方法，包括：使用可植入医疗装置（IMD）感测电描记图; 使用多遍处理确定心电图的至少一个通道上的心跳位置，从而产生一组多通拍位置; 将电描记图和设备识别的节拍位置存储在存储器位置中; 以及从存储器位置检索电描记图和设备标识的拍摄位置。 多遍处理确定心电图的至少第一个通道的位置。 然后将设备识别的拍摄位置组与使用多遍方法识别的拍摄位置的多通道组进行比较。 基于比较步骤，可以检测节拍过度，节拍不足或来自装置的噪音。

公开(公告)号：US07938781B2

公开(公告)日：2011-05-10

申请号：US12813073

申请日：2010-06-10

Applicant: Gerrard M. Carlson ,  Yayun Lin

Inventor： Gerrard M. Carlson ,  Yayun Lin

IPC: A61B5/02

CPC classification number: A61N1/3962 ,  A61B5/02028 ,  A61B5/024 ,  A61B5/02405 ,  A61B7/04 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36578 ,  A61N1/37247 ,  A61N1/37282

Abstract: A method comprises detecting at least one episode of ventricular tachyarrhythmia in a subject using an implantable medical device (IMD), sensing at least one heart sound signal for the subject using the IMD, the heart sound signal associated with mechanical vibration of a heart of the subject; initiating, in response to and during the detected episode of tachyarrhythmia, a measurement of hemodynamic stability of the ventricular tachyarrhythmia from the heart sound signal, and deeming whether the ventricular tachyarrhythmia is stable according to the measurement of hemodynamic stability. The measurement of hemodynamic stability is determined using linear prediction.

Abstract translation: 一种方法包括使用可植入医疗装置（IMD）检测受试者中的至少一次心室快速性心律失常，使用IMD感测对象的至少一个心音信号，与心脏的心脏的机械振动相关的心音信号 学科; 响应于和在检测到的快速性心律失常发作期间，从心脏声音信号测量心室快速性心律失常的血液动力学稳定性，并且根据血液动力学稳定性的测量来确定心室性心律失常是否稳定。 使用线性预测确定血液动力学稳定性的测量。

公开(公告)号：US20110077541A1

公开(公告)日：2011-03-31

申请号：US12879147

申请日：2010-09-10

Applicant: Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

Inventor： Yanting Dong ,  Shijie Zhang ,  Dan Li ,  Yayun Lin

IPC: A61B5/04

CPC classification number: A61B5/04525 ,  G06K9/00536

Abstract: A system and method for automatically analyzing a cardiac signal, including the step of providing an episode database on a computer storage medium including a plurality of episode data records of one or more patients. Each episode data record includes a cardiac signal from at least one data-generating device. The method also includes the step of selecting one or more of the N beats to be one or more beat templates, for at least a first cardiac signal having N beats. Another step is determining a value K for the cardiac signal using a computer system where K beat templates can represent all the N beats in the cardiac signal.

Abstract translation: 一种用于自动分析心脏信号的系统和方法，包括在包括一个或多个患者的多个发作数据记录的计算机存储介质上提供情节数据库的步骤。 每个剧集数据记录包括来自至少一个数据生成装置的心脏信号。 该方法还包括为至少具有N次拍子的第一个心脏信号选择N个节拍中的一个或多个作为一个或多个节拍模板的步骤。 另一步是使用计算机系统确定心脏信号的值K，其中K搏动模板可以表示心脏信号中的所有N个搏动。

公开(公告)号：US07908001B2

公开(公告)日：2011-03-15

申请号：US11209976

申请日：2005-08-23

Applicant: Dan Li ,  Yayun Lin

Inventor： Dan Li ,  Yayun Lin

IPC: A61N1/39

CPC classification number: A61N1/3622 ,  A61B5/04525 ,  A61B5/0464 ,  A61N1/36585 ,  A61N1/3962

Abstract: Methods and systems for selecting tachyarrhythmia therapy based on the morphological organization level of the arrhythmia are described. Morphological organization levels of arrhythmias are associated with cardiac therapies. The morphological organization levels are related to cardiac signal morphologies of the arrhythmias. An arrhythmia episode is detected and the morphological organization level of the arrhythmia episode is determined. A cardiac therapy associated with the morphological organization level of the arrhythmia episode is delivered to treat the arrhythmia. For example, the morphological organization levels may be associated with the cardiac therapies based on one or more of retrospective database analysis, patient therapy tolerance, and physician input. The associations may be static or may be dynamically adjusted based on therapy efficacy.

Abstract translation: 描述了基于心律失常形态组织水平选择快速性心律失常治疗的方法和系统。 心律失常的形态学组织水平与心脏治疗有关。 形态组织水平与心律失常的心脏信号形态有关。 检测到心律失常发作，确定心律失常发作的形态组织水平。 与心律失常发作的形态组织水平相关的心脏治疗被递送以治疗心律失常。 例如，形态组织水平可以基于回顾性数据库分析，患者治疗耐受性和医师输入中的一种或多种与心脏疗法相关联。 协会可以是静态的，或者可以基于治疗功效来动态调整。

公开(公告)号：US07780606B2

公开(公告)日：2010-08-24

申请号：US11277773

申请日：2006-03-29

Applicant: Gerrard M. Carlson ,  Yayun Lin

Inventor： Gerrard M. Carlson ,  Yayun Lin

IPC: A61B5/02

CPC classification number: A61N1/3962 ,  A61B5/02028 ,  A61B5/024 ,  A61B5/02405 ,  A61B7/04 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36578 ,  A61N1/37247 ,  A61N1/37282

Abstract: A system comprising an implantable medical device (IMD). The IMD includes an implantable sensor operable to produce an electrical signal representative of mechanical activity of a heart of a subject and a controller circuit coupled to the sensor. The IMD also includes a heart sound sensor interface circuit to produce a heart sound signal, a tachyarrhythmia detector, and a controller circuit. The controller circuit includes a hemodynamic stability assessment module configured to determine that at least one episode of ventricular tachyarrhythmia is detected in a subject and obtain a measurement of hemodynamic stability of the ventricular tachyarrhythmia from the heart sound signal.

Abstract translation: 一种包括可植入医疗装置（IMD）的系统。 IMD包括可植入传感器，其可操作以产生代表受试者心脏的机械活动的电信号和耦合到传感器的控制器电路。 IMD还包括产生心脏声音信号的心脏声音传感器接口电路，快速心律失常检测器和控制器电路。 控制器电路包括血液动力学稳定性评估模块，其被配置为确定在受试者中检测到至少一次心室快速性心律失常发作，并且从心脏声音信号获得心室快速性心律失常的血液动力学稳定性的测量。

公开(公告)号：US20080281370A1

公开(公告)日：2008-11-13

申请号：US11744952

申请日：2007-05-07

Applicant: Yayun Lin ,  Shelley M. Cazares ,  Donald L. Hopper

Inventor： Yayun Lin ,  Shelley M. Cazares ,  Donald L. Hopper

IPC: A61N1/02

CPC classification number: A61N1/3702 ,  A61B5/02028 ,  A61B5/02405 ,  A61B5/0464 ,  A61N1/3627 ,  A61N1/36592

Abstract: An indication of an actual or potential heart failure condition is computed. One example includes monitoring a first heart rate preceding a first onset of a first sinus tachyarrhythmia episode. Upon detecting the first sinus tachyarrhythmia episode, the indication is automatically provided using information about the first heart rate and how quickly the first onset occurs.

Abstract translation: 计算出实际或潜在的心力衰竭状况的指示。 一个例子包括监测在第一次窦性心律失常发作的第一次发作之前的第一心率。 在检测到第一窦性心律失常发作时，使用关于第一心率的信息以及第一次发作发生的速度自动提供指示。

公开(公告)号：US20070142736A1

公开(公告)日：2007-06-21

申请号：US11312279

申请日：2005-12-20

Applicant: Shelley Cazares ,  Carlos Ricci ,  Dan Li ,  Yayun Lin ,  Yi Zhang ,  Jaeho Kim ,  Joseph Bocek

Inventor： Shelley Cazares ,  Carlos Ricci ,  Dan Li ,  Yayun Lin ,  Yi Zhang ,  Jaeho Kim ,  Joseph Bocek

IPC: A61B5/04

CPC classification number: A61N1/3622 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/7264 ,  A61N1/3702 ,  A61N1/3962

Abstract: Cardiac arrhythmias are classified based on the morphology of the arrhythmia episode beats. Templates are formed using morphological features of the cardiac beats of the episode. The arrhythmia episode is classified as a monomorphic tachyarrhythmia or polymorphic tachyarrhythmia based on the one or more templates. The arrhythmia episode may be classified based on a number templates formed from the arrhythmia episode. The templates are formed by determining a measure of similarity between morphological features of a cardiac beat to a template. The similarities can be determined based on a pairing rule that determines which beat morphologies are compared. Selection of therapy for treating the arrhythmia episode may depend on the historical success of a therapy at mitigating previous arrhythmias of the same type as the arrhythmia episode.

Abstract translation: 心律失常根据心律失常发作的形态进行分类。 使用情节心脏搏动的形态学特征形成模板。 基于一个或多个模板，心律失常发作被分类为单形性快速性心律失常或多态性快速性心律失常。 心律失常发作可以基于由心律失常发作形成的数字模板进行分类。 模板通过确定心跳的形态特征与模板之间的相似性的度量来形成。 可以基于确定哪些拍子形态进行比较的配对规则来确定相似度。 选择治疗心律失常发作的治疗可能取决于治疗在缓解与心律失常事件相同类型的以前心律失常方面的历史成功。

公开(公告)号：US20060111643A1

公开(公告)日：2006-05-25

申请号：US10996340

申请日：2004-11-23

Applicant: Shelley Cazares ,  Julie Thompson ,  Yayun Lin

Inventor： Shelley Cazares ,  Julie Thompson ,  Yayun Lin

IPC: A61B5/04

CPC classification number: A61B5/04525 ,  A61B5/0031 ,  A61B5/0464 ,  A61B5/726 ,  A61N1/3622

Abstract: This document discusses, among other things, a method of identifying a non-fatal tachyarrhythmia episode by determining a degree of similarity between the episode and a template generated from a previous tachyarrhythmia episode.

Abstract translation: 本文件尤其涉及通过确定发作与从先前的快速性心律失常发作产生的模板之间的相似程度来识别非致命性快速性心律失常发作的方法。

公开(公告)号：US06917830B2

公开(公告)日：2005-07-12

申请号：US10643770

申请日：2003-08-19

Applicant: Surekha Palreddy ,  Carlos Ricci ,  Yayun Lin

Inventor： Surekha Palreddy ,  Carlos Ricci ,  Yayun Lin

IPC: A61B5/0452 ,  A61B5/046 ,  A61N1/37 ,  A61B5/04

CPC classification number: A61B5/0452 ,  A61B5/046 ,  A61B5/7221 ,  A61N1/37 ,  A61N1/3704 ,  A61N1/3718 ,  Y10S128/901

Abstract: An implantable cardiac rhythm management device is configured to estimating the noise level and noise floor in a sensing channel by measuring the magnitude of signal in the sensing channel when noise is determined to be present or absent, respectively. The presence or absence of noise may be determined by computing the density of local peaks or inflection points in an electrogram waveform. The computed local peak density is then used to set or clear a noise flag, which signifies whether noise is present or not. A noise statistic computed from samples of the electrogram signal obtained through a sensing channel may then be used to estimate a noise level or a noise floor.

Abstract translation: 可植入心律管理装置被配置为通过分别在确定噪声存在或不存在时通过测量感测通道中的信号的幅度来估计感测通道中的噪声电平和噪声底限。 噪声的存在或不存在可以通过计算电描记图波形中局部峰值或拐点的密度来确定。 然后使用计算的局部峰值密度来设置或清除噪声标志，其表示是否存在噪声。 然后可以使用从通过感测通道获得的电描记图信号的样本计算的噪声统计量来估计噪声水平或噪声底噪。