公开(公告)号：US08754210B2

公开(公告)日：2014-06-17

申请号：US13382235

申请日：2010-07-07

Applicant: Young Lag Cho ,  Sang Eun Chae ,  Seong Jin Kim ,  Ho Young Song ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim ,  Jinhwa Lee ,  Suk Ho Lee

Inventor： Young Lag Cho ,  Sang Eun Chae ,  Seong Jin Kim ,  Ho Young Song ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim ,  Jinhwa Lee ,  Suk Ho Lee

IPC: C07D413/10 ,  C07D413/14 ,  C07D253/065 ,  C07D409/10

CPC classification number: C07D413/14 ,  C07D253/06 ,  C07D409/12

Abstract: Disclosed are: a method for preparing a 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)thiophene-2-carboxamide derivative, which is a inhibitor of blood coagulation factor Xa, in a high purity and yield; and a novel intermedicate used therein.

Abstract translation: 公开的是：制备5-氯-N - （{（5S）-2-氧-3- [4-（5,6-二氢-4H- [1,2,4]三嗪-1-基 ）苯基] -1,3-恶唑烷-5-基} - 甲基）噻吩-2-甲酰胺衍生物，其是凝血因子Xa的抑制剂，其纯度高，产率高; 和其中使用的新颖的介入。

公开(公告)号：US20130072482A1

公开(公告)日：2013-03-21

申请号：US13699970

申请日：2011-05-26

Applicant: Beom-Seok Yang ,  Yong-Zu Kim ,  Tae-Kyo Park ,  Sung-Ho Woo ,  Hyang-Sook Lee ,  Sun-Young Kim ,  Jong-Un Cho ,  Hong-Bum Lee

Inventor： Beom-Seok Yang ,  Yong-Zu Kim ,  Tae-Kyo Park ,  Sung-Ho Woo ,  Hyang-Sook Lee ,  Sun-Young Kim ,  Jong-Un Cho ,  Hong-Bum Lee

IPC: A61K31/519 ,  A61K31/5377 ,  A61K31/4545 ,  A61P17/02 ,  A61K31/4365 ,  A61P29/00 ,  A61P37/00 ,  C07D495/04 ,  A61K31/496

CPC classification number: C07D495/04

Abstract: The present invention is for the anti-inflammatory compounds that have an inhibitory activity against protein tyrosine kinases and their pharmaceutical composition(s) containing the compound as the active ingredient. Since the compounds of the present invention can inhibit multiple protein kinases associated with inflammatory diseases and immune disorders, they are useful for their prevention or treatment.

Abstract translation: 本发明涉及对蛋白酪氨酸激酶具有抑制活性的抗炎化合物及其含有该化合物作为活性成分的药物组合物。 由于本发明的化合物可以抑制与炎性疾病和免疫疾病相关的多种蛋白激酶，因此它们可用于其预防或治疗。

公开(公告)号：US08288423B2

公开(公告)日：2012-10-16

申请号：US12598010

申请日：2008-05-09

Applicant: Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

Inventor： Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC: A01N43/64 ,  A01N43/76 ,  A01N43/50 ,  A01N43/02 ,  A01N43/06 ,  A61K31/41 ,  A61K31/42 ,  A61K31/415 ,  A61K31/38

CPC classification number: C07D413/14

Abstract: The present invention relates to novel oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof, and processes for preparing the same, and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof can be usefully employed as an anticoagulant for treating thromboembolism and tumors via inhibition of coagulation factor Xa.

Abstract translation: 本发明涉及具有环脒的新的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐及其制备方法，以及包含其的药物组合物。 具有环脒的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐可有效地用作通过抑制凝血因子Xa治疗血栓栓塞和肿瘤的抗凝血剂。

公开(公告)号：US20110178293A1

公开(公告)日：2011-07-21

申请号：US13120568

申请日：2009-09-22

Applicant: Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

Inventor： Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC: C07D413/10 ,  C07D403/10 ,  C07D403/14

CPC classification number: C07D403/08

Abstract: Disclosed is a novel oxazolidinone derivative, particularly a novel oxazolidinone compound with a cyclic amidoxime or cyclic amidrazone group. Also disclosed is a pharmaceutical antibiotic composition including a novel oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof as an effective ingredient. Because the novel oxazolidinone derivative, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof or a pharmaceutically acceptable salt thereof exhibits a wide antibacterial spectrum against resistant bacteria, a low toxicity, and a strong antibacterial activity against Gram-positive and Gram-negative bacteria, it can be usefully used as an antibiotic.

Abstract translation: 公开了一种新的恶唑烷酮衍生物，特别是具有环偕胺肟或环状氨基腙基团的新型恶唑烷酮化合物。 还公开了包含新型恶唑烷酮衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为有效成分的药物抗生素组合物。 由于新的恶唑烷酮衍生物，其前体药物，其水合物，其溶剂化物，其异构体或其药学上可接受的盐对抗菌细菌具有广泛的抗菌谱，低毒性和抗革兰氏阳性和 革兰氏阴性菌，可有效地用作抗生素。

公开(公告)号：US20100184781A1

公开(公告)日：2010-07-22

申请号：US12598010

申请日：2008-05-09

Applicant: Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

Inventor： Young Lag Cho ,  Ho Young Song ,  Dae Yon Lee ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sang Hui Jo ,  Yeon Ok Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC: A61K31/506 ,  C07D413/14 ,  A61K31/422 ,  C07D409/14 ,  A61K31/4439 ,  A61P9/10 ,  A61P29/00 ,  A61P9/00

CPC classification number: C07D413/14

Abstract: The present invention relates to novel oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof, and processes for preparing the same, and pharmaceutical compositions comprising the same. The oxazolidinone derivatives with cyclic amidines, and prodrugs, hydrates, solvates, isomers and pharmaceutically acceptable salts thereof can be usefully employed as an anticoagulant for treating thromboembolism and tumors via inhibition of coagulation factor Xa.

Abstract translation: 本发明涉及具有环脒的新的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐及其制备方法，以及包含其的药物组合物。 具有环脒的恶唑烷酮衍生物及其前体药物，水合物，溶剂合物，异构体和药学上可接受的盐可有效地用作通过抑制凝血因子Xa治疗血栓栓塞和肿瘤的抗凝血剂。

公开(公告)号：US07723319B2

公开(公告)日：2010-05-25

申请号：US12585229

申请日：2009-09-09

Applicant: Dong-Gyu Cho ,  Jae-Hong Lim ,  Jae-Taeg Hwang ,  Woo-Young Cho ,  Hyun-Sook Jang ,  Chang-Ho Lee ,  Tae-Saeng Choi ,  Chung-Mi Kim ,  Yong-Zu Kim ,  Tae-Kyun Kim ,  Seung-Joo Cho ,  Gyoung-Won Kim ,  Jong-Ryoo Choi ,  Jeong-Min Kim ,  Kee-Yoon Roh

Inventor： Dong-Gyu Cho ,  Jae-Hong Lim ,  Jae-Taeg Hwang ,  Woo-Young Cho ,  Hyun-Sook Jang ,  Chang-Ho Lee ,  Tae-Saeng Choi ,  Chung-Mi Kim ,  Yong-Zu Kim ,  Tae-Kyun Kim ,  Seung-Joo Cho ,  Gyoung-Won Kim ,  Jong-Ryoo Choi ,  Jeong-Min Kim ,  Kee-Yoon Roh

IPC: C07F9/6561 ,  C07F9/6512 ,  C07F9/40 ,  A61K31/675 ,  A61P31/20

CPC classification number: C07H19/10 ,  C07F9/65616 ,  C07H19/20

Abstract: The present invention relates to an acyclic nucleoside phosphonate derivative which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.

Abstract translation: 本发明涉及可用作抗病毒剂（特别是针对乙型肝炎病毒）的无环核苷膦酸酯衍生物，其药学上可接受的盐，立体异构体及其制备方法。

公开(公告)号：US07157448B2

公开(公告)日：2007-01-02

申请号：US10450780

申请日：2002-01-18

Applicant: Jong-Ryoo Choi ,  Jeong-Min Kim ,  Kee-Yoon Roh ,  Dong-Gyu Cho ,  Jae-Hong Lim ,  Jae-Taeg Hwang ,  Woo-Young Cho ,  Hyun-Sook Jang ,  Chang-Ho Lee ,  Tae-Saeng Choi ,  Chung-Mi Kim ,  Yong-Zu Kim ,  Tae-Kyun Kim ,  Seung-Joo Cho ,  Gyoung-Won Kim

Inventor： Jong-Ryoo Choi ,  Jeong-Min Kim ,  Kee-Yoon Roh ,  Dong-Gyu Cho ,  Jae-Hong Lim ,  Jae-Taeg Hwang ,  Woo-Young Cho ,  Hyun-Sook Jang ,  Chang-Ho Lee ,  Tae-Saeng Choi ,  Chung-Mi Kim ,  Yong-Zu Kim ,  Tae-Kyun Kim ,  Seung-Joo Cho ,  Gyoung-Won Kim

IPC: C07F9/6561 ,  C07F9/6512 ,  C07F9/40 ,  A61K31/675 ,  A61P31/20

CPC classification number: C07H19/10 ,  C07F9/65616 ,  C07H19/20

Abstract: The present invention relates to a nucleoside phosphonate derivative represented by formula (1): pharmaceutically acceptable salts, and stereoisomers. This nucleoside phosphonate derivative is useful as an antiviral agent, particularly, against hepatitis B virus. Also disclosed are processes for the preparation of the nucleoside phosphonate derivative. Also disclosed are methods treating hepatitis B by administering a nucleoside phosphonate derivative of formula (1).

Abstract translation: 本发明涉及由式（1）表示的核苷膦酸酯衍生物：其药学上可接受的盐和立体异构体。 该核苷膦酸衍生物可用作抗病毒剂，特别是乙型肝炎病毒。 还公开了制备核苷膦酸酯衍生物的方法。 还公开了通过施用式（1）的核苷膦酸酯衍生物治疗乙型肝炎的方法。

公开(公告)号：US20060293284A1

公开(公告)日：2006-12-28

申请号：US11455679

申请日：2006-06-20

Applicant: Dong-Gyu Cho ,  Jae-Hong Lim ,  Jae-Taeg Hwang ,  Woo-Young Cho ,  Hyun-Sook Jang ,  Chang-Ho Lee ,  Tae-Saeng Choi ,  Chung-Mi Kim ,  Yong-Zu Kim ,  Tae-Kyun Kim ,  Seung-Joo Cho ,  Gyoung-Won Kim ,  Jong-Ryoo Choi ,  Jeong-Min Kim ,  Kee-Yoon Roh

Inventor： Dong-Gyu Cho ,  Jae-Hong Lim ,  Jae-Taeg Hwang ,  Woo-Young Cho ,  Hyun-Sook Jang ,  Chang-Ho Lee ,  Tae-Saeng Choi ,  Chung-Mi Kim ,  Yong-Zu Kim ,  Tae-Kyun Kim ,  Seung-Joo Cho ,  Gyoung-Won Kim ,  Jong-Ryoo Choi ,  Jeong-Min Kim ,  Kee-Yoon Roh

IPC: A61K31/675 ,  C07F9/6512

CPC classification number: C07H19/10 ,  C07F9/65616 ,  C07H19/20

Abstract: The present invention relates to an acyclic nucleoside phosphonate derivative which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.

Abstract translation: 本发明涉及可用作抗病毒剂（特别是针对乙型肝炎病毒）的无环核苷膦酸酯衍生物，其药学上可接受的盐，立体异构体及其制备方法。

公开(公告)号：US06436921B1

公开(公告)日：2002-08-20

申请号：US09508656

申请日：2000-05-18

Applicant: Sang Woo Park ,  Dong Kin Kim ,  Kye-Jung Shin ,  Yong Koo Kang ,  Yong Zu Kim ,  Yong Ho Chung ,  Hong Woo Lee ,  Jae Doo Huh ,  Sang Joo Lee ,  Il Hong Suh ,  Bong Suk Ko

Inventor： Sang Woo Park ,  Dong Kin Kim ,  Kye-Jung Shin ,  Yong Koo Kang ,  Yong Zu Kim ,  Yong Ho Chung ,  Hong Woo Lee ,  Jae Doo Huh ,  Sang Joo Lee ,  Il Hong Suh ,  Bong Suk Ko

IPC: C07D47720

CPC classification number: C07D477/20 ,  C07D207/16 ,  Y02P20/55

Abstract: The present invention relates to carbapenem derivatives of Formula I, wherein X is carbonyl or sulfonyl, and a preparation method thereof. The carbapenem derivatives of the invention have excellent antibacterial properties and are thus useful as antibiotics.

Abstract translation: 本发明涉及式I的碳青霉烯衍生物及其制备方法，其中X为羰基或磺酰基。 本发明的碳青霉烯衍生物具有优异的抗菌性能，因此可用作抗生素。

公开(公告)号：US20130165652A1

公开(公告)日：2013-06-27

申请号：US13818420

申请日：2011-08-25

Applicant: Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

Inventor： Hyung Sub Gwak ,  Yong Zu Kim ,  Uk Il Kim ,  Byeong Deog Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Joung Yul Yun ,  Dae Yon Lee ,  Hyang Sook Lee ,  Jeong Eun Jeon ,  Se Kyoo Jeong ,  Hyung Mook Choi

IPC: C07D471/04

CPC classification number: C07D235/08 ,  A61K8/4946 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/008 ,  C07D471/04

Abstract: The heterocyclic compound according to the present invention may treat and prevent inflammatory diseases and heal skin wounds, and particularly, have effects of recovering damaged skin barrier, reducing inflammation and pruritus in inflammatory skin diseases. In addition, the composition containing the compound according to the present invention as an active ingredient may be used to alleviate various inflammatory diseases and diseases in which PAR-2 is excessively expressed, and particularly, the composition may inhibit activity of PAR-2 in skin, such that the composition may be used as a composition having anti-inflammatory function in inflammatory skin diseases including atopic dermatitis, or the like.

Abstract translation: 根据本发明的杂环化合物可以治疗和预防炎性疾病并愈合皮肤伤口，特别是具有恢复受损的皮肤屏障，减少炎性皮肤疾病中的炎症和瘙痒的作用。 此外，含有本发明化合物作为活性成分的组合物可以用于缓和各种炎性疾病和PAR-2过度表达的疾病，特别是该组合物可抑制PAR-2在皮肤中的活性 ，使得该组合物可以用作具有抗炎功能的组合物，所述炎性皮肤病包括特应性皮炎等。