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公开(公告)号：US06294573B1
公开(公告)日：2001-09-25
申请号：US09492567
申请日：2000-01-27
Applicant: Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Joseph F. Dellaria, Jr. , Alan S. Florjancic , Jianchun Gong , Yan Guo , Howard R. Heyman , James H. Holms , Michael R. Michaelides , Jamie R. Stacey , Douglas H. Steinman , Carol K. Wada , Lianhong Xu
Inventor： Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Joseph F. Dellaria, Jr. , Alan S. Florjancic , Jianchun Gong , Yan Guo , Howard R. Heyman , James H. Holms , Michael R. Michaelides , Jamie R. Stacey , Douglas H. Steinman , Carol K. Wada , Lianhong Xu
IPC: C07C25537
CPC classification number: C07D263/04 , C07D207/09 , C07D207/48 , C07D307/14 , C07D317/28
Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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公开(公告)号：US20050020603A1
公开(公告)日：2005-01-27
申请号：US10842292
申请日：2004-05-10
Applicant: Yujia Dai , Steven Davidsen , Anna Ericsson , Kresna Hartandi , Zhiqin Ji , Michael Michaelides
Inventor： Yujia Dai , Steven Davidsen , Anna Ericsson , Kresna Hartandi , Zhiqin Ji , Michael Michaelides
IPC: A61K31/4162 , A61K31/4439 , A61K31/496 , A61K31/501 , A61K31/506 , C07
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US08063091B2
公开(公告)日：2011-11-22
申请号：US12507575
申请日：2009-07-22
Applicant: Yujia Dai , Steven K. Davidsen , Anna M. Ericsson , Kresna Hartandi , Zhiqin Ji , Michael R. Michaelides
Inventor： Yujia Dai , Steven K. Davidsen , Anna M. Ericsson , Kresna Hartandi , Zhiqin Ji , Michael R. Michaelides
IPC: A61K31/415 , C07D231/56
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US07598283B2
公开(公告)日：2009-10-06
申请号：US11867887
申请日：2007-10-05
Applicant: Yujia Dai , Steven K. Davidsen , Anna M. Ericsson , Kresna Hartandi , Zhiqin Ji , Michael R. Michaelides
Inventor： Yujia Dai , Steven K. Davidsen , Anna M. Ericsson , Kresna Hartandi , Zhiqin Ji , Michael R. Michaelides
IPC: A61K31/423 , C07D261/20
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US07560552B2
公开(公告)日：2009-07-14
申请号：US10392951
申请日：2003-03-20
Applicant: Michael R. Michaelides , Lee D. Arnold , Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Robin R. Frey , Yan Guo , Zhiqin Ji , Neil Wishart
Inventor： Michael R. Michaelides , Lee D. Arnold , Michael L. Curtin , Yujia Dai , Steven K. Davidsen , Robin R. Frey , Yan Guo , Zhiqin Ji , Neil Wishart
IPC: C07D495/04 , A61K31/519 , A61P35/04 , A61P19/02 , A61P3/10 , A61P37/06
CPC classification number: C07D495/04 , C07D513/04
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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Patent Agency Ranking
公开(公告)号：US20090054430A1
公开(公告)日：2009-02-26
申请号：US12174334
申请日：2008-07-16
Applicant: Yujia Dai , Ji Zhiqin , Michael R. Michaelides
Inventor： Yujia Dai , Ji Zhiqin , Michael R. Michaelides
IPC: A61K31/423 , C07D261/20 , C07D231/56 , C07D413/02 , A61K31/416 , A61K31/5377 , A61K31/496
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04
Abstract: Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Abstract translation: 公开了抑制极光激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。
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公开(公告)号：US20080076767A1
公开(公告)日：2008-03-27
申请号：US11867887
申请日：2007-10-05
Applicant: Yujia Dai , Steven Davidsen , Anna Ericsson , Kresna Hartandi , Zhiqin Ji , Michael Michaelides
Inventor： Yujia Dai , Steven Davidsen , Anna Ericsson , Kresna Hartandi , Zhiqin Ji , Michael Michaelides
IPC: A61K31/416 , A61K31/4178 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D231/56 , C07D261/20 , C07D401/02 , C07D403/02 , C07D413/02
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US07297709B2
公开(公告)日：2007-11-20
申请号：US10842292
申请日：2004-05-10
Applicant: Yujia Dai , Steven K. Davidsen , Anna M. Ericsson , Kresna Hartandi , Zhiqin Ji , Michael R. Michaelides
Inventor： Yujia Dai , Steven K. Davidsen , Anna M. Ericsson , Kresna Hartandi , Zhiqin Ji , Michael R. Michaelides
IPC: A61K31/4439 , C07D49/02
CPC classification number: C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12
Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
Abstract translation: 具有该式的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。
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公开(公告)号：US20070135387A1
公开(公告)日：2007-06-14
申请号：US11636189
申请日：2006-12-08
Applicant: Michael Michaelides , William McClellan , Robin Frey , Michael Curtin , Douglas Steinman , Yujia Dai , James Holms
Inventor： Michael Michaelides , William McClellan , Robin Frey , Michael Curtin , Douglas Steinman , Yujia Dai , James Holms
IPC: A61K31/675 , A61K31/519 , C07D487/02 , C07F9/6512
CPC classification number: C07F9/6561 , C07D487/04 , C07D495/04
Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Abstract translation: 公开了抑制蛋白激酶的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。
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20.发明授权Synthesis of optically active helical ladder polymers with unbroken double-bond conjugation 失效具有不间断双键共轭的光学活性螺旋梯形聚合物的合成
公开(公告)号：US5830984A
公开(公告)日：1998-11-03
申请号：US671417
申请日：1996-06-27
Applicant: Thomas J. Katz , Yujia Dai
Inventor： Thomas J. Katz , Yujia Dai
CPC classification number: C08G73/06
Abstract: Optically active ladder polymers that are chiral and have an unbroken network of conjugated double bonds along a helical path are synthesized.
Abstract translation: 合成具有手性且沿着螺旋路径具有不间断的共轭双键网络的光学活性梯度聚合物。
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