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22 条记录 (耗时 0.018 秒)

    Medicament for the treatment of viral skin and tumour diseases
    12.
    发明授权
    Medicament for the treatment of viral skin and tumour diseases 有权
    用于治疗病毒性皮肤和肿瘤疾病的药物

    公开(公告)号：US07858662B2

    公开(公告)日：2010-12-28

    申请号：US10495889

    申请日：2002-11-18

    申请人： Yunik Chang ,  Robert Lathrop ,  Erwin Böhm ,  Irene Gander-Meisterernst ,  Regina Greger ,  Johanna Holldack ,  Ulrich Moebius

    发明人： Yunik Chang ,  Robert Lathrop ,  Erwin Böhm ,  Irene Gander-Meisterernst ,  Regina Greger ,  Johanna Holldack ,  Ulrich Moebius

    IPC分类号： A61K31/20 ,  A61K31/12 ,  A61K31/35 ,  A61P15/00

    CPC分类号： A61K9/0014 ,  A61K31/23 ,  A61K31/353 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  Y10S514/934 ,  Y10S514/947 ,  Y10S514/967 ,  Y10S514/969 ,  A61K2300/00

    摘要： The invention relates to a medicament containing a compound of general formula (1), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkynyl group, preferably a C11-C15 alkyl, alkylene or alkynyl group, particularly a C11-C13 alkyl, alkylene or alkynyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkynyl group, preferably a C1-C6 alkyl, alkylene or alkynyl group, in particular a C2-C4 alkyl, alkylene or alkynyl group, most preferably a C3 alkyl group, a —[CH2—(CH2)m—O]nH group with n=1 to 10, preferably n=1 to 5, m=1 to 5, preferably m=1 to 3, a —CH2—[CH—(OH)]p[CH2—(R3)]— group, where R3=independent H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumor diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.

    摘要翻译： 本发明涉及含有通式（1）化合物的药物，其中R 1独立地为直链或支链的，饱和的，单或多不饱和的任选取代的C 11 -C 21烷基，亚烷基或炔基，优选C 11 -C 15烷基，亚烷基或炔基，特别是C 11 -C 13烷基，亚烷基或炔基，最优选C 13烷基，R 2独立地为直链或支链C 1 -C 8烷基，亚烷基或炔基， C 1 -C 6烷基，亚烷基或炔基，特别是C 2 -C 4烷基，亚烷基或炔基，最优选C 3烷基， - n = 1-10的α-[CH 2 - （CH 2）m -O] n H基团 n = 1至5，m = 1至5，优选m = 1至3，-CH 2 - [CH-（OH）] p [CH 2 - （R 3）] - 基，其中R 3 =独立的H或OH，p = 1至7，优选p = 1至4，戊糖基或己糖基，作为治疗活性剂，单独或与一种或几种其它药剂组合，作为tr的组合制剂 特别是由人乳头状瘤病毒（HPV）和/或疱疹病毒引起的病毒性皮肤疾病和/或肿瘤疾病，以及局部作用的药物制剂及其用途。

    Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
    15.
    发明授权
    Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols 失效
    油酸，油精和油醇与低级醇的二元体系渗透增强

    公开(公告)号：US4863970A

    公开(公告)日：1989-09-05

    申请号：US218702

    申请日：1988-07-13

    申请人： Dinesh C. Patel ,  Yunik Chang

    发明人： Dinesh C. Patel ,  Yunik Chang

    IPC分类号： A61K9/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14

    CPC分类号： A61K47/14 ,  A61K47/10 ,  A61K47/12 ,  A61K9/0014 ,  Y10S514/947

    摘要： Penetration-enhancing pharmaceutical compositions for topical transepidermal and percutaneous application are disclosed which are non-irritating to the skin. These compositions are made up of a safe and effective amount of an active pharmaceutical permeant, including hydrophilic salt forms, contained in a novel penetration-enhancing vehicle comprising, (i) 1-95% w. of a cell-envelope disordering compound selected from the group consisting of oleic acid, oleyl alcohol, glycerol monoleate, glycerol dioleate, glycerol trioleate and mixtures thereof, (ii) 5-75% w., and preferably 5-49% w., of a lower alkanol selected from the group consisting of ethanol, propanol and isopropanol and mixtures thereof and (iii) 0-45% w., and preferably 1-45% w., of an inert diluent which, according to properties of the permeant used, may range from hydrophilic to hydrophobic. Water, polyethylene or polypropylene glycols and mineral oil are exemplary diluents.

    摘要翻译： 公开了用于局部经皮和经皮应用的渗透增强药物组合物，其对皮肤无刺激性。 这些组合物由安全有效量的包含亲水盐形式的活性药物渗透剂组成，其包含在新的渗透增强载体中，其包含（i）1-95％w。 选自油酸，油醇，甘油单油酸酯，甘油二油酸酯，甘油三油酸酯及其混合物的细胞包膜失调化合物，（ii）5-75重量％，优选5-49重量％ 的选自乙醇，丙醇和异丙醇的低级链烷醇及其混合物，和（iii）0-45％重量，优选1-45％重量的惰性稀释剂，其根据渗透剂的性质 使用，可以从亲水到疏水。 水，聚乙烯或聚丙二醇和矿物油是示例性的稀释剂。

    TETRACYCLINE STABILIZING FORMULATIONS
    18.
    发明申请
    TETRACYCLINE STABILIZING FORMULATIONS 审中-公开
    四氯化碳稳定配方

    公开(公告)号：US20120028929A1

    公开(公告)日：2012-02-02

    申请号：US13119547

    申请日：2009-09-18

    申请人： David F. Power ,  Greg Fieldson ,  Yunik Chang

    发明人： David F. Power ,  Greg Fieldson ,  Yunik Chang

    IPC分类号： A61K31/65 ,  A61P31/04 ,  A61P27/02 ,  A61P17/00 ,  A61P29/00 ,  A61P17/10

    CPC分类号： A61K9/0048 ,  A61K31/65 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/38

    摘要： An aqueous solution comprising a chelating agent at a concentration of about 0.1-0.5%, and an antioxidant agent at a concentration of about 0.1-0.5%, wherein the pH of the solution is between about 4.5 and about 7.5 is disclosed. The aqueous solution may comprise a tetracycline composition wherein the tetracycline is formulated in the aqueous solution. A method for reducing the rate and/or overall extent of degradation of a tetracycline in aqueous solution, comprising admixing in a tetracycline containing solution a chelating agent at a concentration of about 0.1-0.5% and an antioxidant at a concentration of about 0.1-0.5% and, as necessary, adjusting the pH of the solution so that it is between about 4.5 and about 7.5 is also disclosed. Tetracycline compositions of the invention may be used to treat inflammatory and/or tissue degeneration conditions.

    摘要翻译： 包含浓度为约0.1-0.5％的螯合剂和浓度为约0.1-0.5％的抗氧化剂的水溶液，其中溶液的pH为约4.5至约7.5。 水溶液可以包含四环素组合物，其中将四环素配制在水溶液中。 一种用于降低水溶液中四环素降解速率和/或总体程度的方法，包括在含有四环素的溶液中混合浓度为约0.1-0.5％的螯合剂和约0.1-0.5浓度的抗氧化剂 ％，并且根据需要调节溶液的pH使其在约4.5至约7.5之间。 本发明的四环素组合物可用于治疗炎症和/或组织变性病症。

    Device for administering an active agent to the skin or mucosa
    20.
    发明授权
    Device for administering an active agent to the skin or mucosa 失效
    用于向皮肤或粘膜施用活性剂的装置

    公开(公告)号：US4983395A

    公开(公告)日：1991-01-08

    申请号：US326536

    申请日：1989-03-21

    申请人： Yunik Chang ,  Dinesh C. Patel ,  Charles D. Ebert

    发明人： Yunik Chang ,  Dinesh C. Patel ,  Charles D. Ebert

    IPC分类号： A61F13/02 ,  A61K9/70

    CPC分类号： A61K9/703 ,  A61K9/7084

    摘要： A transdermal drug delivery device comprising a drug formulation-containing reservoir defined by a backing layer and a drug-permeable membrane layer, a peelable inner liner that underlies the reservoir and a portion of the backing/membrane outwardly of the reservoir periphery, an adhesive layer that underlies the inner liner and outwardly extending portions of the membrane/backing layers, and a peelable release liner layer that underlies the adhesive layer with a first permanent heat seal between the backing and the membrane about the perimeter of the reservoir and another concentric peelable (impermanent) heat seal between the membrane and the inner liner positioned underlying and at a radius not less than the first permanent heat seal, the heat seals and peelable barrier layer providing barriers that isolate the drug formulation from the adhesive.

    摘要翻译： 一种透皮药物递送装置，其包括由背衬层和药物可渗透膜层限定的含药物制剂储存器，位于储存器下方的可剥离内衬层和位于储存器周边外部的背衬/膜的一部分，粘合剂层 位于膜/背衬层的内衬层和向外延伸部分之下的可剥离剥离衬垫层，以及位于粘合剂层下面的可剥离衬垫层，其中衬垫和膜周围围绕储存器的第一永久热密封，另一个同心可剥离（ 膜和内衬之间的热密封，其位于下方并且半径不小于第一永久热封，热密封和可剥离阻挡层提供将药物制剂与粘合剂隔离的障碍物。