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公开(公告)号：US11324681B2
公开(公告)日：2022-05-10
申请号：US16955224
申请日：2018-12-18
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Katie F. Wlaschin , Amanda C. Engler , Hannah C. Cohen , Yizhong Wang , Tao Gong , Tiffany T. Ton , Joel D. Oxman , Jie Yang
IPC: A61K8/36 , A61K8/9794 , A61K8/365 , A61K8/42 , A61K8/49 , A61K8/67 , A61K8/73 , A61K8/92 , A61Q11/00
Abstract: Compositions that include: from 5 wt-% to 70 wt-% of one or more plant based oils based on the total weight of the composition; from 35 wt-% to 95 wt-% of an aqueous phase based on the total weight of the composition; not greater than 7.5 wt-% of one or more surfactants based on the total weight of the composition; and not greater than 3 wt-% of a viscosity modifier of, wherein the composition has a pH from 4.5 to 9.5, the composition is an oil in water (o/w) emulsion, and the composition is edible. Methods of utilizing disclosed compositions are also included.
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![N-1 branched cycloalkyl substituted imidazo[4,5-c]quinoline compounds, compositions, and methods](/abs-image/US/2024/01/30/US11884662B2/abs.jpg.150x150.jpg)
12.发明授权公开(公告)号：US11884662B2
公开(公告)日：2024-01-30
申请号：US17250073
申请日：2019-05-23
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： George W. Griesgraber , Hannah C. Cohen , Jana Ninkovic
IPC: C07D471/04 , A61P37/02 , A61K31/4745
CPC classification number: C07D471/04 , A61K31/4745 , A61P37/02
Abstract: Imidazo[4,5-c]quinoline compounds of Formula (I) having a substituent that is attached at the N−1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.
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公开(公告)号：US20230406855A1
公开(公告)日：2023-12-21
申请号：US18251578
申请日：2021-10-15
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： George W. Griesgraber , Mark A. Tomai , Hannah C. Cohen , Devon M. Hunerdosse
IPC: C07D471/04 , A61K47/54
CPC classification number: C07D471/04 , A61K47/545
Abstract: Imidazoquinoline compounds, salts thereof, conjugates thereof, pharmaceutical compositions containing the compounds and conjugates, and methods of use of such compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals.
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公开(公告)号：US11801231B2
公开(公告)日：2023-10-31
申请号：US16226122
申请日：2018-12-19
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Katie F. Wlaschin , Amanda C. Engler , Hannah C. Cohen , Yizhong Wang , Tao Gong , Tiffany T. Ton , Joel D. Oxman , Jie Yang
CPC classification number: A61K31/164 , A61K9/0053 , A61K9/107 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/44 , A61P1/02
Abstract: Compositions that include from 0.1 wt-% to 8 wt-% of one or more compounds of formula (I) based on the total weight of the composition
HOCH2—(CHOH)n—CH2NR1R2 (I)
wherein R1 and R2 are independently selected from the group consisting of a hydrogen atom, an alkyl group, C(O)R3, and SO2R4; with R3 and R4 being independently selected from the group consisting of an alkyl group, an aryl group, and an aralkyl group; wherein n is an integer from about 2 to about 5; from 5 wt-% to 95 wt-% of one or more plant based oils based on the total weight of the composition; from 5 wt-% to 80 wt-% water based on the total weight of the composition and from 0.01 wt-% to 1 wt-% of one or more nonionic aromatic phenolic preservatives based on the total weight of the composition wherein the composition has a pH from 4.5 to 9.5, the composition is an emulsion, and the composition is edible.-
公开(公告)号：US20220211603A1
公开(公告)日：2022-07-07
申请号：US17594914
申请日：2020-05-18
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Richard P. Rusin , Jie Yang , Petra L. Kohler Riedi , Jodi L. Connell , Ingo Haeberlein , Hannah C. Cohen , Katie F. Wlaschin , Paul R. Klaiber , Yizhong Wang , Joel D. Oxman , Tiffany T. Ton , Roxanne A. Boehmer
Abstract: A composition comprising from 1 wt-% to 3 wt-% total of glucosamine a derivative of glucosamine, or a combination thereof based on the total weight of the composition, and from 0.3 wt-% to 3 wt-% total of one or more surfactants, based on the total weight of the composition, of Formula (I): HOCH2—(OHOH)n—CH2NR1R2 (I) wherein R1 and R2 are independently selected from the group consisting of a hydrogen atom, an alkyl group, C(O)R3 and SO2R4 with R3 and R4 being independently selected from the group consisting of an alkyl group, an aryl group and an aralkyl group, wherein n is an integer from 2 to 5.
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Patent Agency Ranking
公开(公告)号：US20220192953A1
公开(公告)日：2022-06-23
申请号：US17594878
申请日：2020-05-20
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Richard P. Rusin , Jie Yang , Petra L. Kohler Riedi , Jodi L. Connell , Ingo Haeberlein , Katie F. Wlaschin , Hannah C. Cohen , Tiffany T. Ton , Paul R. Klaiber , Yizhong Wang , Joel D. Oxman
Abstract: A composition comprising: from 0.2 wt-% to 3 wt-% total of arginine, glycine, or a combination thereof based on the total weight of the composition; and from 0.3 wt-% to 3 wt-% total of one or more surfactants, based on the total weight of the composition, of Formula I: HOCH2—(CHOH)n—CH2NR1R2 (I) wherein R1 and R2 are independently selected from the group consisting of a hydrogen atom, an alkyl group, C(O)R3, and SO2R4; with R3 and R4 being independently selected from the group consisting of an alkyl group, an aryl group, and an aralkyl group; wherein n is an integer from about 2 to about 5.
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![N-1 BRANCHED ALKYL SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, COMPOSITIONS, AND METHODS](/abs-image/US/2022/06/09/US20220177471A1/abs.jpg.150x150.jpg)
17.发明申请公开(公告)号：US20220177471A1
公开(公告)日：2022-06-09
申请号：US17594415
申请日：2020-05-27
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： George W. Griesgraber , Michael J. Rice , Hannah C. Cohen , Devon M. Hunerdosse , Adam D. Miller , Joshua R. Wurst
IPC: C07D471/04
Abstract: Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing (or inhibiting) cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.
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公开(公告)号：US20220080019A1
公开(公告)日：2022-03-17
申请号：US17419516
申请日：2019-12-26
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Hannah C. Cohen , Katie F. Wlaschin , Yizhong Wang , Amanda C. Engler , Jie Yang , Tiffany T. Ton , Joel D. Oxman
IPC: A61K36/886 , A61K9/00 , A61K47/44 , A61K47/42 , A61K47/36 , A61K31/519 , A61K31/728 , A61K31/198 , A61K31/205 , A61K31/355 , A61K31/714 , A61K31/4425 , A61K31/155 , A61K45/06 , A61K47/02
Abstract: Articles that include not greater than 60 wt-% of one or more plant based oil that is solid at 25° C. (room temperature), the weight percent based on the total weight of the article; and from 4 wt-% to 10 wt-% of gelatin, from 0.8 to 5 wt-% of agar, or a combination thereof, the weight percent based on the total weight of the article, wherein the article is solid set and homogeneous. Methods of using the articles and compositions for forming the articles are also disclosed.
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公开(公告)号：US20220079976A1
公开(公告)日：2022-03-17
申请号：US17419527
申请日：2019-12-27
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Hannah C. Cohen , Katie F. Wlaschin , Yizhong Wang , Amanda C. Engler , Jie Yang , Tiffany T. Ton , Joel D. Oxman
Abstract: Articles that include from 70 wt-% to 99 wt-% of one or more plant based oil that is solid at 25° C., the weight percent based on the total weight of the article; and from 0.5 wt-% to 10 wt-% of fumed silica, the weight percent based on the total weight of the article. Methods of use of the articles are also included.
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公开(公告)号：US20190083220A1
公开(公告)日：2019-03-21
申请号：US16196872
申请日：2018-11-20
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Katie F. Wlaschin , Amanda C. Engler , Hannah C. Cohen , Yizhong Wang , Tao Gong , Tiffany T. Ton , Joel D. Oxman , Jie Yang , Richard P. Rusin
IPC: A61C19/06 , A61P1/02 , A61K9/00 , A61K31/355 , A61K31/714 , A61K31/198 , A61K31/728 , A61K31/164 , A61K31/205 , A61K36/28 , A61K36/48 , A61K36/52 , A61K36/81 , A61K36/736 , A61K36/752 , A61K36/63 , A61K31/025 , A61K31/075
Abstract: Compositions that include: from 5 wt-% to 30 wt-% of one or more plant based oils based on the total weight of the composition; from 70 wt-% to 95 wt-% of an aqueous phase based on the total weight of the composition; from 0.1 wt-% to 5 wt-% of one or more surfactants based on the total weight of the composition; and from 0.05 wt-% to 3 wt-% of a viscosity modifier, wherein the composition has a pH from 4.5 to 9.5, the composition is an oil in water (o/w) emulsion, and the composition is edible. Methods of utilizing disclosed compositions are also included.
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