公开(公告)号：US11021453B2

公开(公告)日：2021-06-01

申请号：US16717813

申请日：2019-12-17

Applicant: Lundbeck La Jolla Research Center, Inc. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Micah J. Niphakis ,  Jae Won Chang ,  Kenneth M. Lum ,  Benjamin F. Cravatt

IPC: C07D295/205 ,  A61P25/22 ,  C07C271/12 ,  C07D317/46 ,  C07D317/58 ,  C07D231/12 ,  C07D231/16 ,  C07D231/56 ,  C07D241/04 ,  C07D471/04 ,  C07D471/10 ,  C07D261/08 ,  C07D487/04 ,  C07D263/32 ,  C07D205/04 ,  C07D491/107 ,  C07D207/14 ,  C07D271/06 ,  C07D307/79 ,  C07D405/14 ,  C07D215/42 ,  C07D213/40 ,  C07D295/26 ,  C07D213/55 ,  C07D401/04 ,  C07D407/06 ,  C07D413/06 ,  C07C271/10 ,  C07D207/09 ,  C07D213/38 ,  C07D215/46 ,  C07D401/10 ,  C07D403/10 ,  C07D413/10

Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for a method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.

公开(公告)号：US10336709B2

公开(公告)日：2019-07-02

申请号：US15764231

申请日：2016-09-29

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. Grice ,  Micah Niphakis ,  Todd K. Jones

IPC: C07D233/80 ,  C07D233/86

Abstract: Provided herein are lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors, pharmaceutical compositions thereof, and methods of their use for the treatment of disease.

公开(公告)号：US09828379B2

公开(公告)日：2017-11-28

申请号：US14902324

申请日：2014-07-01

Applicant: Abide Therapeutics, Inc.

Inventor： Todd K. Jones ,  Justin S. Cisar ,  Cheryl A. Grice ,  Dong-Hui Wang ,  Olivia D. Weber

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/407

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, N,N-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.

公开(公告)号：US09771341B2

公开(公告)日：2017-09-26

申请号：US15072229

申请日：2016-03-16

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Olivia D. Weber ,  Dong-Hui Wang

IPC: C07D295/205 ,  C07D207/08 ,  C07D207/12 ,  C07D295/26 ,  C07D211/38 ,  C07D211/58 ,  C07D207/14 ,  C07D211/14 ,  C07D498/08 ,  C07D211/62 ,  C07D403/04 ,  C07D401/04 ,  C07D417/04 ,  C07D487/04 ,  C07D471/10 ,  C07D265/30 ,  C07D207/16

CPC classification number: C07D295/205 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/14 ,  C07D211/38 ,  C07D211/58 ,  C07D211/62 ,  C07D265/30 ,  C07D295/26 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D471/10 ,  C07D487/04 ,  C07D498/08

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20150080364A1

公开(公告)日：2015-03-19

申请号：US14383076

申请日：2013-03-15

Applicant: Abide Therapeutics, Inc. ,  The Scripps Research Insititute

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Dong-Hui Wang ,  Olivia Weber ,  Benjamin F. Cravatt ,  Micah J. Niphakis ,  Armand Cognetta ,  Jae Won Chang

IPC: C07D207/46 ,  C07D401/12 ,  C07D487/04 ,  C07D491/107 ,  C07D471/04 ,  C07D405/14 ,  C07D413/12

CPC classification number: C07D207/46 ,  C07D209/48 ,  C07D233/80 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.

Abstract translation: 本文提供了可用于治疗例如疼痛，实体瘤和/或肥胖症的氨基甲酸酯化合物。

公开(公告)号：US10323038B2

公开(公告)日：2019-06-18

申请号：US15777201

申请日：2016-11-18

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. Grice ,  Todd K. Jones ,  Katharine K. Duncan ,  Justin S. Cisar ,  Jeffrey E. Merit ,  Olivia D. Weber

IPC: C07D487/10 ,  C07D487/04 ,  C07D471/10 ,  C07D519/00 ,  C07D403/06 ,  C07D491/08 ,  C07D231/40 ,  C07D231/38 ,  C07D403/12 ,  C07D417/12 ,  C07D401/12 ,  C07D413/12 ,  C07D498/08

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

公开(公告)号：US10030020B2

公开(公告)日：2018-07-24

申请号：US15593239

申请日：2017-05-11

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Olivia D. Weber ,  Daniel J. Buzard ,  Michael B. Shaghafi

IPC: C07D471/10 ,  C07D519/00

Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US09994537B2

公开(公告)日：2018-06-12

申请号：US15672165

申请日：2017-08-08

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Olivia D. Weber ,  Dong-Hui Wang

IPC: C07D295/205 ,  C07D207/08 ,  C07D471/10 ,  C07D417/04 ,  C07D403/04 ,  C07D401/04 ,  C07D295/26 ,  C07D265/30 ,  C07D207/12 ,  C07D211/38 ,  C07D211/58 ,  C07D207/14 ,  C07D211/14 ,  C07D498/08 ,  C07D211/62 ,  C07D487/04 ,  C07D207/16

CPC classification number: C07D295/205 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/14 ,  C07D211/38 ,  C07D211/58 ,  C07D211/62 ,  C07D265/30 ,  C07D295/26 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D471/10 ,  C07D487/04 ,  C07D498/08

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.