公开(公告)号：US3453266A

公开(公告)日：1969-07-01

申请号：US3453266D

申请日：1966-03-14

Applicant: AMERICAN HOME PROD

Inventor： WEI PETER H L ,  BELL STANLEY C

IPC: C07D285/36 ,  C07D93/40 ,  C07D41/06

CPC classification number: C07D285/36

公开(公告)号：US3448116A

公开(公告)日：1969-06-03

申请号：US3448116D

申请日：1966-04-25

Applicant: AMERICAN HOME PROD

Inventor： MCCAULLY RONALD J ,  BELL STANLEY C ,  RUSSELL PETER B

IPC: C07C275/64 ,  C07D233/72 ,  C07D233/80 ,  C07D233/86 ,  C07D49/32

CPC classification number: C07D233/86 ,  C07C275/64 ,  C07D233/80

公开(公告)号：US3384660A

公开(公告)日：1968-05-21

申请号：US56239266

申请日：1966-07-01

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C

IPC: C07C233/00 ,  C07D243/24

CPC classification number: C07D243/24 ,  C07C233/00

公开(公告)号：US3344136A

公开(公告)日：1967-09-26

申请号：US41458364

申请日：1964-11-30

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C ,  CHILDRESS SCOTT J

IPC: C07D243/24 ,  C07D243/26

CPC classification number: C07D243/24

公开(公告)号：US3336296A

公开(公告)日：1967-08-15

申请号：US23346762

申请日：1962-10-26

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C ,  CHILDRESS SCOTT J ,  SULKOWSKI THEODORE S

IPC: C07D243/24

CPC classification number: C07D243/24

公开(公告)号：US3296251A

公开(公告)日：1967-01-03

申请号：US26122963

申请日：1963-02-26

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C ,  WEI PETER H L ,  CARL GOCHMAN

IPC: C07D401/04 ,  C07D405/04 ,  C07D409/04

CPC classification number: C07D401/04 ,  C07D405/04 ,  C07D409/04

公开(公告)号：US3296249A

公开(公告)日：1967-01-03

申请号：US28550063

申请日：1963-06-04

Applicant: AMERICAN HOME PROD

Inventor： BELL STANLEY C

IPC: C07D243/26 ,  C07D409/04

CPC classification number: C07D409/04 ,  Y10S514/906

公开(公告)号：US3294791A

公开(公告)日：1966-12-27

申请号：US53377566

申请日：1966-03-14

Applicant: AMERICAN HOME PROD

Inventor： WEI PETER H L ,  BELL STANLEY C

IPC: C07D513/08

CPC classification number: C07D513/08

公开(公告)号：US3912733A

公开(公告)日：1975-10-14

申请号：US46805374

申请日：1974-05-08

Applicant: AMERICAN HOME PROD

Inventor： SANTILLI ARTHUR A ,  SCOTESE ANTHONY C ,  BELL STANLEY C

IPC: C07D311/86 ,  C07D295/00

CPC classification number: C07D311/86 ,  Y10S514/821

Abstract: The disclosure is directed to 1-substituted-6-(2-hydroxy-3substituted aminopropoxy)xanthen-9-ones which have the formula

WHERE R1 is hydrogen or di(lower)alkylamino(lower)alkyl; and R2 and R3 when taken separately are hydrogen or lower alkyl and when taken together with the nitrogen atom to which they are attached are morpholino, piperazino, N-lower alkyl-piperazino, piperidino, lower alkylpiperidino and phen(lower)alkyl piperidino. The compounds exhibit antiarrhythmic activity when evaluated in standard pharmacological procedures or are intermediates in the preparation of compounds having antiarrhythmic activity. Also some of the compounds have anti inflammatory activity.

Abstract translation: 本公开涉及具有式WHERE R 1为氢或二（低级）烷基氨基（低级）烷基的1-取代-6-（2-羟基-3-取代氨基丙氧基）呫吨-9-酮。 和R2和R3分别是氢或低级烷基，当与它们所连接的氮原子一起时，是吗啉代，哌嗪子基，N-低级烷基 - 哌嗪子基，哌啶子基，低级烷基哌啶子基和苯基（低级）哌啶子基。

公开(公告)号：US3632644A

公开(公告)日：1972-01-04

申请号：US3632644D

申请日：1969-10-14

Applicant: AMERICAN HOME PROD

Inventor： MCCAULLY RONALD J ,  BELL STANLEY C

IPC: C07C101/04 ,  C07C53/14

CPC classification number: C07C205/59

Abstract: HOOC-CH2-NH-OH (I)--> HOOC-CH2-N(-CO-CH3)-OOC-CH3 (II)-->

D R A W I N G
1. 2-(N-ACETYL-N-ACETOXYAMINO)ACETYL CHLORIDE.

(I) --> CH3-COO-CO-CH2-N(-CO-CH3)-OOC-CH3 (VI) --> (IV)

3H-1,4-BENZODIAZEPINE (V)

2-(O=),4-(O=),5-PHENYL,7-(CL-)-1,2-DIHYDRO-

BENZENE (IV)-->

1-(PHENYL-CO-),3-(CL-),6-(CH3-COO-N(-CO-CH3)-CH2-CO-NH-)

CL-CO-CH2-N(-CO-CH3)-OOC-CH3 (III)-->