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公开(公告)号：US20240327461A1
公开(公告)日：2024-10-03
申请号：US18497081
申请日：2024-06-11
Applicant: AMGEN INC.
Inventor： Jerry Ryan HOLDER , Gayathri SWAMINATH , Michael J. FROHN , Brian Alan LANMAN , Anthony B. REED , Leslie P. MIRANDA , John Gordon ALLEN , Alexander J. PICKRELL , Aaron C. SIEGMUND , Lewis D. PENNINGTON , Bryant YANG
CPC classification number: C07K7/08 , A61K38/10 , A61K47/542 , A61K47/60 , C07K14/47 , A61K38/00 , C07K2319/30
Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
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公开(公告)号：US20230159510A1
公开(公告)日：2023-05-25
申请号：US17799077
申请日：2021-02-11
Applicant: AMGEN INC.
Inventor： Jennifer Rebecca ALLEN , Albert AMEGADZIE , Diane Jennifer BEYLKIN , Shon BOOKER , Matthew Paul BOURBEAU , John R. BUTLER , Michael J. FROHN , Sanne Ormholt Schroder GLAD , Birgitte Weinreich HUSEMOEN , Matthew R. KALLER , Todd J. KOHN , Brian Alan LANMAN , Kexue LI , Qingyian LIU , Patricia LOPEZ , Vu Van MA , Francesco MANONI , Jose MEDINA , Ana Elena MINATTI , Jorge PEIRO CADAHIA , Liping PETTUS , Alexander J. PICKRELL , Ian SARVARY , Nuria A. TAMAYO , Mikkel VESTERGAARD
IPC: C07D413/14 , C07D471/04 , C07D401/14 , C07D401/12 , C07D405/14
CPC classification number: C07D413/14 , C07D401/12 , C07D401/14 , C07D405/14 , C07D471/04
Abstract: Described herein are compounds of Formula I and pharmaceutically acceptable salt thereof, stereoisomers, tautomers as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders. Compounds of Formula I have the following structure: (I)
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Patent Agency Ranking
公开(公告)号：US20220395504A1
公开(公告)日：2022-12-15
申请号：US17363878
申请日：2021-06-30
Applicant: Amgen Inc.
Inventor： John Gordon ALLEN , Jennifer Rebecca ALLEN , Ana Elena MINATTI , Qiufen XUE , Ryan Paul WURZ , Christopher M. TEGLEY , Alexander J. PICKRELL , Thomas T. NGUYEN , Vu Van MA , Patricia LOPEZ , Longbin LIU , David John KOPECKY , Michael J. FROHN , Ning CHEN , Jian Jeffrey CHEN , Aaron C. SIEGMUND , Albert AMEGADZIE , Nuria A. TAMAYO , Shon BOOKER , Clifford GOODMAN , Mary WALTON , Nobuko NISHIMURA , Youngsook SHIN , Jonathan D. LOW , Victor J. CEE , Anthony B. REED , Hui-Ling WANG , Brian Alan LANMAN
IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20210261619A1
公开(公告)日：2021-08-26
申请号：US17160819
申请日：2021-01-28
Applicant: AMGEN INC.
Inventor： Jerry Ryan HOLDER , Gayathri SWAMINATH , Michael J. FROHN , Brian Alan LANMAN , Anthony B. REED , Leslie P. MIRANDA , John Gordon ALLEN , Alexander J. PICKRELL , Aaron C. SIEGMUND , Lewis D. PENNINGTON , Bryant YANG
Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
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公开(公告)号：US20200069657A1
公开(公告)日：2020-03-05
申请号：US16675121
申请日：2019-11-05
Applicant: AMGEN INC.
Inventor： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY
IPC: A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D275/04 , C07D471/08 , C07D403/04 , C07D401/04 , C07D513/04 , C07D487/04 , C07D417/04 , C07D239/80 , C07D487/10 , C07D471/04
Abstract: Provided herein are methods of treating cancer with KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20180177767A1
公开(公告)日：2018-06-28
申请号：US15849905
申请日：2017-12-21
Applicant: AMGEN INC.
Inventor： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY
IPC: A61K31/428 , A61K31/496 , A61K31/519 , A61K31/517 , A61K31/5025 , A61K31/502 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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17.发明申请公开(公告)号：US20160102075A1
公开(公告)日：2016-04-14
申请号：US14973491
申请日：2015-12-17
Applicant: AMGEN INC.
Inventor： Jennifer R. ALLEN , Jian J. CHEN , Michael J. FROHN , Essa Hu HARRINGTON , Qingyian LIU , Alexander J. PICKRELL , Shannon RUMFELT , Robert M. RZASA , Wenge ZHONG
IPC: C07D401/14 , C07D409/14 , C07D403/14 , C07D491/107 , C07D487/10 , C07C53/18 , C07D405/14 , C07D413/14 , C07D487/04 , C07D491/08 , C07D487/08 , C07D471/04 , C07D491/056 , C07D513/04 , C07D417/14
CPC classification number: C07D401/14 , C07C53/18 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/056 , C07D491/08 , C07D491/107 , C07D513/04
Abstract: Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
Abstract translation: 式（I）的不饱和氮杂环化合物：如说明书中所定义，含有它们的组合物，以及制备这些化合物的方法。 本文还提供治疗通过抑制PDE10可治疗的疾病或疾病的方法，例如肥胖症，亨廷顿舞蹈病，非胰岛素依赖性糖尿病，精神分裂症，双相障碍，强迫症等。
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