公开(公告)号：US20170205409A1

公开(公告)日：2017-07-20

申请号：US15129370

申请日：2015-03-19

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  The United States of America, as Represented by the Secretary, Department of Health and Human Serv

Inventor： Karen Anderson ,  Elizabeth Unger

IPC: G01N33/569 ,  G01N33/574

CPC classification number: G01N33/56983 ,  C12Q1/6886 ,  C12Q1/708 ,  G01N33/57407 ,  G01N33/57411 ,  G01N2333/025

Abstract: Methods and systems for detection of HPV mediated cervical or oropharyneal cancer are provided. The methods include contacting a fluid sample from a patient with multiple antibodies to HPV16 early gene proteins and comparing patterns of HPV16 antibody bound to said early gene proteins with a control associated with cervical or oropharyneal cancer (FIG. 1).

公开(公告)号：US12298300B2

公开(公告)日：2025-05-13

申请号：US17232631

申请日：2021-04-16

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  RECOGNITION ANALYTIX INC.

Inventor： Stuart Lindsay ,  Karen Anderson ,  Mark Knappenberger ,  Sepideh Afsari Mamaghani ,  Jacob L. Swett

IPC: G01N33/53 ,  C12N9/22 ,  C12N15/11 ,  G01N27/02

Abstract: The present disclosure provides devices, systems, and methods related to single molecule detection. In particular, the present disclosure provides devices and methods for sequence-specific detection of a nucleic acid target using current fluctuations as a readout for protein binding to the nucleic acid target. As described herein, certain aspects of the bioelectronic devices and method can be used to detect and identify any nucleic acid target for the purpose of diagnosis and/or treatment.

公开(公告)号：US20240368572A1

公开(公告)日：2024-11-07

申请号：US18778083

申请日：2024-07-19

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Radwa Ewaisha ,  Samira Kiani ,  Shayesteh Roshdi Ferdosi ,  Karen Anderson ,  Farzaneh Moghadam ,  Sri Krishna ,  Mo Reza Ebrahimkhani

IPC: C12N9/22 ,  A61K48/00 ,  G01N33/573

Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.

公开(公告)号：US12085569B2

公开(公告)日：2024-09-10

申请号：US17940883

申请日：2022-09-08

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： Joshua LaBaer ,  Jie Wang ,  Ji Qiu ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC: G01N33/574 ,  C07K16/30 ,  C12Q1/6886 ,  G01N33/564 ,  C12N15/11

CPC classification number: G01N33/57415 ,  C07K16/3015 ,  C12Q1/6886 ,  G01N33/564 ,  C12N15/11 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US20220163531A1

公开(公告)日：2022-05-26

申请号：US17563279

申请日：2021-12-28

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Benjamin Katchman ,  Karen Anderson ,  Garrick Wallstrom ,  Joshua LaBaer ,  Daniel Cramer

IPC: G01N33/574

Abstract: Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.

公开(公告)号：US20200377871A1

公开(公告)日：2020-12-03

申请号：US16632782

申请日：2018-04-27

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Radwa Ewaisha ,  Samira Kiani ,  Shayesteh Roshdi Ferdosi ,  Karen Anderson ,  Farzaneh Moghadam ,  Sri Krishna ,  Mo Reza Ebrahimkhani

IPC: C12N9/22 ,  G01N33/573

Abstract: Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation.

公开(公告)号：US20240402178A1

公开(公告)日：2024-12-05

申请号：US18804843

申请日：2024-08-14

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： Joshua LaBaer ,  Jie Wang ,  Ji Qiu ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC: G01N33/574 ,  C07K16/30 ,  C12N15/11 ,  C12Q1/6886 ,  G01N33/564

Abstract: Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US20210325379A1

公开(公告)日：2021-10-21

申请号：US17232631

申请日：2021-04-16

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  RECOGNITION ANALYTIX INC.

Inventor： Stuart Lindsay ,  Karen Anderson ,  Mark Knappenberger ,  Sepideh Afsari Mamaghani ,  Jacob L. Swett

IPC: G01N33/53 ,  C12N15/11 ,  C12N9/22 ,  G01N27/02

Abstract: The present disclosure provides devices, systems, and methods related to single molecule detection. In particular, the present disclosure provides devices and methods for sequence-specific detection of a nucleic acid target using current fluctuations as a readout for protein binding to the nucleic acid target. As described herein, certain aspects of the bioelectronic devices and method can be used to detect and identify any nucleic acid target for the purpose of diagnosis and/or treatment.

公开(公告)号：US20180320230A1

公开(公告)日：2018-11-08

申请号：US15770323

申请日：2016-10-27

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joshua LaBaer ,  Karen Anderson ,  Ji Qiu ,  Sri Krishna

IPC: C12Q1/6881 ,  G01N33/569 ,  G01N33/554

CPC classification number: C12Q1/6881 ,  G01N33/554 ,  G01N33/56972

Abstract: Provided herein are methods of classifying antigens and epitopes as being recognized by an individual's cellular immune response. More particularly, provided herein are methods for unbiased determination of which antigens are recognized by a population of T cells.

公开(公告)号：US12196757B2

公开(公告)日：2025-01-14

申请号：US17563279

申请日：2021-12-28

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Benjamin Katchman ,  Karen Anderson ,  Garrick Wallstrom ,  Joshua LaBaer ,  Daniel Cramer

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/574

Abstract: Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.