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公开(公告)号：US11243208B2
公开(公告)日：2022-02-08
申请号：US16317184
申请日：2017-07-11
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
IPC分类号： G01N31/00 , G01N33/53 , G01N33/574
摘要： Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.
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公开(公告)号：US20190302122A1
公开(公告)日：2019-10-03
申请号：US16317184
申请日：2017-07-11
申请人： Benjamin KATCHMAN , Karen ANDERSON , Garrick WALLSTROM , Joshua LABAER , Daniel CRAMER , ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
IPC分类号： G01N33/574
摘要： Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.
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公开(公告)号：US20220163531A1
公开(公告)日：2022-05-26
申请号：US17563279
申请日：2021-12-28
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
IPC分类号： G01N33/574
摘要： Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.
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4.发明申请公开(公告)号：US20170059563A1
公开(公告)日：2017-03-02
申请号：US15308330
申请日：2015-05-01
IPC分类号： G01N33/543 , G01N21/64 , A61B5/00 , B01L3/00
CPC分类号： G01N33/54366 , A61B5/0071 , A61B5/6802 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/025 , B01L2200/12 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0825 , B01L2300/087 , B01L2300/123 , G01N21/05 , G01N21/6428 , G01N21/6454 , G01N33/54373 , G01N2021/6439 , G01N2201/0221
摘要： A fully integrated miniaturized optical biosensor and methods of making the same are disclosed. The biosensor may include a fluid transport system and an optical system.
摘要翻译： 公开了一种完全集成的小型化光学生物传感器及其制造方法。 生物传感器可以包括流体输送系统和光学系统。
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公开(公告)号：US11543407B2
公开(公告)日：2023-01-03
申请号：US15308330
申请日：2015-05-01
IPC分类号： G01N33/543 , B01L3/00 , G01N21/64 , G01N21/05 , A61B5/00
摘要： A fully integrated miniaturized optical biosensor and methods of making the same are disclosed. The biosensor may include a fluid transport system and an optical system.
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6.发明授权公开(公告)号：US10591474B2
公开(公告)日：2020-03-17
申请号：US15579038
申请日：2016-05-06
IPC分类号： G01N33/543 , G01N33/58 , B01L3/00 , G01N21/64 , G01N33/68
摘要： Systems and methods for low-cost point-of-care immunoassay are provided. The system comprises an emitter, two optical interference filters, a microscope slide, a photodiode detector, a circuit, and a measuring unit. The detector is placed upon the second filter, the slide, the first filter, and then the emitter. The emitter comprises non-organic light emitting diodes (LEDs) or organic light emitting diodes (OLEDs) that emits light of a first color. The slide is spotted with biofluid from a patient. Biomarkers in the biofluid is bound with immobilized fluorophores that emit light of a second color when stimulated by the light of the first color. The first and second filters band-pass the light of the first and second colors, respectively. The detector detects light of the second color. The current outputted from the detector is converted into a relatively-large output voltage by a circuit. A measuring unit measures the ramp time of the output voltage. The ramp time is to be used to determine the concentration of the fluorophores, which in turn is related to the concentration of the biomarkers.
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7.发明申请公开(公告)号：US20180172681A1
公开(公告)日：2018-06-21
申请号：US15579038
申请日：2016-05-06
IPC分类号： G01N33/543 , G01N33/58 , G01N33/68 , B01L3/00 , G01N21/64
CPC分类号： G01N33/54373 , B01L3/502715 , G01N21/6428 , G01N33/54386 , G01N33/58 , G01N33/582 , G01N33/6857 , G01N2333/025
摘要： Systems and methods for low-cost point-of-care immunoassay are provided. The system comprises an emitter, two optical interference filters, a microscope slide, a photodiode detector, a circuit, and a measuring unit. The detector is placed upon the second filter, the slide, the first filter, and then the emitter. The emitter comprises non-organic light emitting diodes (LEDs) or organic light emitting diodes (OLEDs) that emits light of a first color. The slide is spotted with biofluid from a patient. Biomarkers in the biofluid is bound with immobilized fluorophores that emit light of a second color when stimulated by the light of the first color. The first and second filters band-pass the light of the first and second colors, respectively. The detector detects light of the second color. The current outputted from the detector is converted into a relatively-large output voltage by a circuit. A measuring unit measures the ramp time of the output voltage. The ramp time is to be used to determine the concentration of the fluorophores, which in turn is related to the concentration of the biomarkers.
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