公开(公告)号：US20190004051A1

公开(公告)日：2019-01-03

申请号：US16069111

申请日：2017-01-11

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  NEW YORK UNIVERSITY

发明人： Joshua Labaer ,  Ji Qiu ,  Jie Wang ,  Garrick Wallstrom ,  Jin Park ,  William Rom ,  Harvey Pass

IPC分类号： G01N33/574

摘要： An immune-proteomic screening of AAb responses using protein arrays has identified two panels of Aab (antigen/antibody complexes) that can potentially differentiate lung adenocarcinoma from smoker controls as well as CT positive benign lung disease. The resulting biomarkers appear to have high specificity so that high risk subjects with a positive CT screen and a positive serum test should get more invasive test such as needle biopsy for a timely cancer diagnosis, among other advantages.

公开(公告)号：US20220373548A1

公开(公告)日：2022-11-24

申请号：US17771595

申请日：2020-10-23

申请人： Arizona Board of Regents on behalf of Arizona State University

发明人： Joshua LaBaer ,  Lusheng Song ,  Ji Qiu ,  Yunro Chung

IPC分类号： G01N33/569 ,  G01N33/574 ,  A61P35/00

摘要： Provided herein are methods, compositions, kits, and systems for detecting Epstein Barr virus infection (EBV) in gastric cancer (GC) patients. In particular, provided herein are methods, composition, kits, and systems for diagnosing and treating EBV-positive gastric cancer (EBV+ GC) in a biological sample of an individual based on the presence and level of antibodies against particular Epstein Barr virus proteins. EBV+ GC is a distinct subtype of gastric cancer and is associated with unique molecular profiles. Also provided herein are methods for providing more personalized therapy for each of these distinct cancer subtypes and methods for determining an Epstein Barr virus-positive gastric cancer antibody signature, and kits comprising components and protocols for performing the methods of this disclosure.

公开(公告)号：US20180320230A1

公开(公告)日：2018-11-08

申请号：US15770323

申请日：2016-10-27

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Joshua LaBaer ,  Karen Anderson ,  Ji Qiu ,  Sri Krishna

IPC分类号： C12Q1/6881 ,  G01N33/569 ,  G01N33/554

CPC分类号： C12Q1/6881 ,  G01N33/554 ,  G01N33/56972

摘要： Provided herein are methods of classifying antigens and epitopes as being recognized by an individual's cellular immune response. More particularly, provided herein are methods for unbiased determination of which antigens are recognized by a population of T cells.

公开(公告)号：US20240287708A1

公开(公告)日：2024-08-29

申请号：US18417216

申请日：2024-01-19

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Joshua Labaer ,  Kevin Gorman ,  Brian Kay ,  Jie Wang ,  Ji Qiu

IPC分类号： C40B30/04 ,  C12N15/10 ,  C12Q1/6811

CPC分类号： C40B30/04 ,  C12N15/1037 ,  C12N15/1041 ,  C12N15/1062 ,  C12Q1/6811

摘要： Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.