公开(公告)号：US20190004051A1

公开(公告)日：2019-01-03

申请号：US16069111

申请日：2017-01-11

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  NEW YORK UNIVERSITY

发明人： Joshua Labaer ,  Ji Qiu ,  Jie Wang ,  Garrick Wallstrom ,  Jin Park ,  William Rom ,  Harvey Pass

IPC分类号： G01N33/574

摘要： An immune-proteomic screening of AAb responses using protein arrays has identified two panels of Aab (antigen/antibody complexes) that can potentially differentiate lung adenocarcinoma from smoker controls as well as CT positive benign lung disease. The resulting biomarkers appear to have high specificity so that high risk subjects with a positive CT screen and a positive serum test should get more invasive test such as needle biopsy for a timely cancer diagnosis, among other advantages.

公开(公告)号：US11525831B2

公开(公告)日：2022-12-13

申请号：US16743906

申请日：2020-01-15

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Joshua LaBaer ,  Jie Wang ,  Ji Qui ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC分类号： G01N33/564 ,  G01N33/574 ,  C07K16/30 ,  C12Q1/6886 ,  C12N15/11

摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US20170363631A1

公开(公告)日：2017-12-21

申请号：US15534203

申请日：2015-12-09

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  NATIONAL INSTITUTES OF HEALTH

发明人： Joshua LaBaer ,  Jie Wang ,  Ji Qiu ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC分类号： G01N33/574 ,  C12Q1/68 ,  C07K16/30 ,  C12N15/11

CPC分类号： G01N33/57415 ,  C07K16/3015 ,  C12N15/11 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/564

摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US20200010899A1

公开(公告)日：2020-01-09

申请号：US16532138

申请日：2019-08-05

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Joshua LaBaer ,  Kristin Gillis ,  Garrick Wallstrom ,  Jin Park ,  Vel Murugan ,  Mitch Magee

IPC分类号： C12Q1/6883

摘要： Disclosed herein are compositions and methods for accurately estimating the absorbed dose of radiation indicated by a subject based on the expression pattern of a panel of radiation-modulated (RM) genes at various time points following exposure of the subject to ionizing radiation.

公开(公告)号：US12085569B2

公开(公告)日：2024-09-10

申请号：US17940883

申请日：2022-09-08

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Joshua LaBaer ,  Jie Wang ,  Ji Qiu ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC分类号： G01N33/574 ,  C07K16/30 ,  C12Q1/6886 ,  G01N33/564 ,  C12N15/11

CPC分类号： G01N33/57415 ,  C07K16/3015 ,  C12Q1/6886 ,  G01N33/564 ,  C12N15/11 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US10787710B2

公开(公告)日：2020-09-29

申请号：US16532138

申请日：2019-08-05

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Joshua LaBaer ,  Kristin Gillis ,  Garrick Wallstrom ,  Jin Park ,  Vel Murugan ,  Mitch Magee

IPC分类号： C12Q1/6883 ,  C12Q1/6827

摘要： Disclosed herein are compositions and methods for accurately estimating the absorbed dose of radiation indicated by a subject based on the expression pattern of a panel of radiation-modulated (RM) genes at various time points following exposure of the subject to ionizing radiation.

公开(公告)号：US20230079737A1

公开(公告)日：2023-03-16

申请号：US17940883

申请日：2022-09-08

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Joshua LaBaer ,  Jie Wang ,  Ji Qiu ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC分类号： G01N33/574 ,  G01N33/564 ,  C07K16/30 ,  C12Q1/6886

摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US20200182874A1

公开(公告)日：2020-06-11

申请号：US16743906

申请日：2020-01-15

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  NATIONAL CANCER INSTITUTE

发明人： Joshua LaBaer ,  Jie Wang ,  Ji Qui ,  Garrick Wallstrom ,  Karen Anderson ,  Jin Park ,  Jonine Figueroa

IPC分类号： G01N33/574 ,  C12Q1/6886 ,  C07K16/30 ,  G01N33/564

摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).

公开(公告)号：US10045990B2

公开(公告)日：2018-08-14

申请号：US15555241

申请日：2016-03-02

申请人： Arizona Board of Regents on behalf of Arizona State University

发明人： Fernanda Festa ,  Joshua Labaer ,  Jin Park ,  Femina Rauf

IPC分类号： A61K31/519 ,  A61K31/517

摘要： Disclosed herein are methods of treating diseases that exhibit over-activation of the ERBB4 pathway, such as breast cancer and lung cancer. The method comprises administering to a subject having a disease that exhibits over-activation of the ERBB4 pathway and a gene expression profile consistent with an ERBB4-sensitive profile a therapeutically effective amount of an ERBB4 inhibitor, wherein the disease is effectively treated. Gene expression profiles of ERBB4-sensitive cells and microarrays suitable for protein-tyrosine kinases are also provided.