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公开(公告)号：US20250073072A1
公开(公告)日：2025-03-06
申请号：US18953999
申请日：2024-11-20
Applicant: Avedro, Inc.
Inventor： Mikhail Smirnov
Abstract: An example system for corneal treatment includes an illumination system to generate cross-linking in at least one selected region of a cornea treated with a cross-linking agent by delivering photoactivating light according to photoactivation parameters. The system includes a controller to receive input relating to treatment parameters, which include the photoactivation parameters. The controller is configured to output information for adjusting the one or more treatment parameters by (A) determining from the input, a distribution of cross-links for at least one selected region of the cornea; and (B) determining, from the distribution of cross-links, a shape change for the cornea. Responsive to the output from the controller, the illumination system is configured to adjust at least one of the one or more photoactivation parameters and determine a shape change according to a biomechanical model, and at least one of a biochemical model or an optical mode.
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公开(公告)号：US12171691B2
公开(公告)日：2024-12-24
申请号：US17434275
申请日：2020-02-26
Applicant: Avedro, Inc.
Inventor： Mikhail Smirnov
Abstract: An example system for corneal treatment includes an illumination system to generate cross-linking in at least one selected region of a cornea treated with a cross-linking agent by delivering photoactivating light according to one or more photoactivation parameters. The system includes a controller to receive input relating to one or more treatment parameters, which include the one or more photoactivation parameters. The controller is configured to output information for adjusting the one or more treatment parameters by (A) determining from the input, a distribution of cross-links for the at least one selected region of the cornea; (B) determining, from the distribution of cross-links, a shape change for the cornea; and (C) determining, from the shape change for the cornea, a change in vision for the subject. Responsive to the output from the controller, the illumination system is configured to adjust at least one of the one or more photoactivation parameters.
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公开(公告)号：US12070618B2
公开(公告)日：2024-08-27
申请号：US17521276
申请日：2021-11-08
Applicant: Avedro, Inc.
Inventor： Marc D. Friedman , Mikhail Smirnov , Pavel Kamaev
CPC classification number: A61N5/0624 , A61F9/0079 , A61F9/029 , A61N5/062 , A61M2202/0208 , A61M2205/3368 , A61M2205/36 , A61M2205/52 , A61M2210/0612 , A61N2005/0626 , A61N2005/0648 , A61N2005/0661
Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.
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公开(公告)号：US20230346601A1
公开(公告)日：2023-11-02
申请号：US18313078
申请日：2023-05-05
Applicant: Avedro, Inc.
Inventor： Desmond C. Adler , Mikhail Smirnov , David Usher , Behrouz Tavakol , Jason Hill , Jie Zhang , Amit Mukherjee , Alex Yildizyan
IPC: A61F9/008
CPC classification number: A61F9/008 , A61F2009/00844 , A61F2009/00897 , A61F2009/00872
Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.
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15.发明申请公开(公告)号：US20220284575A1
公开(公告)日：2022-09-08
申请号：US17689515
申请日：2022-03-08
Applicant: AVEDRO, INC.
Inventor： David Usher , Mikhail Smirnov , Behrouz Tavakol , Grace Elizabeth Lytle
Abstract: An automated process receives input tomography data and generates an optimized (customized) treatment pattern for an individual patient without relying on the physician's analysis and judgment. For example, a method for treating a cornea includes receiving tomographic data for a cornea. The method includes identifying a keratoconic defect in the cornea based on the tomographic data. The method includes segmenting the keratoconic defect into treatment zones based on predefined geometric parameters, wherein the treatment zones indicate where a cross-linking agent is to be applied on the cornea and photoactivated to treat the keratoconic defect.
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Patent Agency Ranking
公开(公告)号：US20220054858A1
公开(公告)日：2022-02-24
申请号：US17521276
申请日：2021-11-08
Applicant: Avedro, Inc.
Inventor： Marc D. Friedman , Mikhail Smirnov , Pavel Kamaev
Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.
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公开(公告)号：US20250161114A1
公开(公告)日：2025-05-22
申请号：US19030052
申请日：2025-01-17
Applicant: Avedro, Inc.
Inventor： Desmond C. Adler , Mikhail Smirnov , David Usher , Behrouz Tavakol , Jason Hill , Jie Zhang , Amit Mukherjee , Alex Yildizyan
IPC: A61F9/008
Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.
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公开(公告)号：US20220151830A1
公开(公告)日：2022-05-19
申请号：US17509337
申请日：2021-10-25
Applicant: Avedro, Inc.
Inventor： Marc D. Friedman , Pavel Kamaev , Mikhail Smirnov
Abstract: A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.
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公开(公告)号：US11219553B2
公开(公告)日：2022-01-11
申请号：US16511500
申请日：2019-07-15
Applicant: Avedro, Inc.
Inventor： Marc D. Friedman , Pavel Kamaev , Mikhail Smirnov
Abstract: A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.
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公开(公告)号：US11167149B2
公开(公告)日：2021-11-09
申请号：US16384099
申请日：2019-04-15
Applicant: Avedro, Inc.
Inventor： Marc D. Friedman , Mikhail Smirnov , Pavel Kamaev
Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.
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