公开(公告)号：US20110043661A1

公开(公告)日：2011-02-24

申请号：US12866304

申请日：2009-02-06

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: H04N5/262 ,  H04N5/225

CPC classification number: H04N5/232 ,  A61B3/102 ,  A61B3/14 ,  G01B9/02007 ,  G01B9/0203 ,  G01B9/02049 ,  G01B9/02069 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/70 ,  G02B21/0056 ,  G02B21/0064 ,  H04N5/2252 ,  H04N5/33

Abstract: The invention describes several embodiments of an adapter which can make use of the devices in any commercially available digital cameras to accomplish different functions, such as a fundus camera, as a microscope or as an en-face optical coherence tomography (OCT) to produce constant depth OCT images or as a Fourier domain (channelled spectrum) optical coherence tomography to produce a reflectivity profile in the depth of an object or cross section OCT images, or depth resolved volumes. The invention admits addition of confocal detection and provides simultaneous measurements or imaging in at least two channels, confocal and OCT, where the confocal channel provides an en-face image simultaneous with the acquisition of OCT cross sections, to guide the acquisition as well as to be used subsequently in the visualisation of OCT images. Different technical solutions are provided for the assembly of one or two digital cameras which together with such adapters lead to modular and portable high resolution imaging systems which can accomplish various functions with a minimum of extra components while adapting the elements in the digital camera. The cost of such adapters is comparable with that of commercial digital cameras, i.e. the total cost of such assemblies of commercially digital cameras and dedicated adapters to accomplish high resolution imaging are at a fraction of the cost of dedicated stand alone instruments. Embodiments and methods are presented to employ colour cameras and their associated optical sources to deliver simultaneous signals using their colour sensor parts to provide spectroscopic information, phase shifting inferometry in one step, depth range extension, polarisation, angular measurements and spectroscopic Fourier domain (channelled spectrum) optical coherence tomography in as many spectral bands simultaneously as the number of colour parts of the photodetector sensor in the digital camera. In conjunction with simultaneous acquistion of a confocal image, at least 4 channels can simultaneously be provided using the three color parts of conventional color cameras to deliver three OCT images in addition to the confocal image.

公开(公告)号：US20080074617A1

公开(公告)日：2008-03-27

申请号：US11547922

申请日：2005-03-11

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: A61B3/10

CPC classification number: G01B9/02091 ,  A61B3/102 ,  G01B9/02083

Abstract: OCT cross section images of a part of a curved object are displayed by creating a series of image points and placing each image point into a corrected image in such a way that the positions of scattering points within the image coincide with or are at least closer to their real spatial distribution within the curved object.

Abstract translation: 通过创建一系列图像点并将每个图像点放置在校正图像中，使得图像内的散射点的位置与图像中的位置一致或至少更接近于图像点来显示弯曲物体的一部分的OCT截面图像 它们在曲线对象内的实际空间分布。

公开(公告)号：US08422023B2

公开(公告)日：2013-04-16

申请号：US12307072

申请日：2007-06-28

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: G01B9/02

CPC classification number: G01N21/4795 ,  A61B3/102 ,  G01B9/0203 ,  G01B9/02063 ,  G01B9/02091 ,  G01B2290/70

Abstract: An optical coherence tomography (OCT) apparatus includes an optical source, an interferometer generating an object beam and a reference beam, a transverse scanner for scanning an object with said object beam, and a processor for generating an OCT image from an OCT signal returned by said interferometer. At least the optical source, the interferometer, and the scanner are mounted on a common translation stage displaceable towards and away from said object. A dynamic focus solution is provided when the scanner and a folded object path are placed on the translation stage.

Abstract translation: 光学相干断层摄影（OCT）装置包括光源，产生物体光束和参考光束的干涉仪，用于用所述物体光束扫描物体的横向扫描仪，以及用于从OCT信号产生OCT图像的处理器， 所述干涉仪。 至少光源，干涉仪和扫描仪安装在可朝向和远离所述物体移动的公共平移台上。 当扫描仪和折叠对象路径放置在平移台上时，提供动态聚焦解决方案。

公开(公告)号：US20120013849A1

公开(公告)日：2012-01-19

申请号：US12835221

申请日：2010-07-13

Applicant: Adrian Podoleanu ,  Michael Leitner

Inventor： Adrian Podoleanu ,  Michael Leitner

IPC: A61B3/10 ,  G01B11/02

CPC classification number: G01B9/02057 ,  A61B3/1005 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02021 ,  G01B9/02044 ,  G01B9/02064 ,  G01B9/0209

Abstract: A spectral interferometry apparatus and method are disclosed, that can be used to monitor or measure an unknown length by following a characteristic of an indicating signal. The measurement is performed by adjusting an optical path difference (OPD) in an interferometer until sound or light or both are obtained with the desired strength and pitch. Embodiments are presented where the unknown length is the eye length. Sound of different pitches are produced by scanning the channeled spectrum output of an interferometer with the object returning at least one of the interferometer optical signals. The scanning is performed by reading the signal of an analogue photodetector array driven by a nonlinear clock or by tuning a low cost swept source using a distorted driving signal.

Abstract translation: 公开了一种光谱干涉测量装置和方法，其可以用于通过遵循指示信号的特性来监视或测量未知长度。 通过调整干涉仪中的光程差（OPD）来进行测量，直到以期望的强度和间距获得声音或光或者两者。 呈现其中未知长度是眼睛长度的实施例。 通过用对象返回干涉仪光信号中的至少一个来扫描干涉仪的信道频谱输出来产生不同音调的声音。 通过读取由非线性时钟驱动的模拟光电检测器阵列的信号或通过使用失真的驱动信号调谐低成本扫频源来执行扫描。

公开(公告)号：US20110109911A1

公开(公告)日：2011-05-12

申请号：US12919026

申请日：2009-02-24

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: G01B9/02

CPC classification number: G01B9/02014 ,  A61B3/102 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02002 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795

Abstract: The invention discloses an optical interferometer which can be used to provide simultaneous measurements over multiple path lengths and methods to employ such an interferometer as to achieve a variety of functions covering simultaneous measurements at different depths separated by an increment of a multiple differential delay matched in the interferometer as well as imaging. Optical sensors, optical coherence tomography (OCT) set-ups, optical sensing methods and OCT methods are disclosed which can provide: (i) multiple en-face images at several depths with dynamic dispersion compensation, (ii) fast acquisition of cross sections, (iii) fast acquisition of 3D volumes of a scattering object while maintaining dynamic focus; (iv) fast acquisition of long axial measurement profiles, non mechanical, with dynamic focus, range scalable, with applications in tracking and OTDR. Methods are disclosed on the combination of scanning regimes and modes of operation to achieve versatile functionality in measurements, in the 3D imaging of moving tissue such as the eye, heart, or moving embryos or functional/low noise imaging by making use of angular compounding or polarisation. A method for elimination of axial movement effects in measuring the flow profile is also disclosed.

Abstract translation: 本发明公开了一种光干涉仪，其可用于提供多路径长度上的同时测量以及采用这种干涉仪的方法，以实现各种功能，覆盖在不同深度处的同时测量，所述多个不同深度由在 干涉仪以及成像。 公开了光学传感器，光学相干断层扫描（OCT）设置，光学感测方法和OCT方法，其可以提供：（i）在几个深度处具有动态色散补偿的多个面部图像，（ii）快速获取横截面， （iii）快速获取散射物体的3D体积，同时保持动态聚焦; （iv）快速获取长轴向测量轮廓，非机械，具有动态聚焦，范围可扩展，应用于跟踪和OTDR。 在扫描方式和操作模式的组合中公开了方法，以在测量中进行多功能功能，在移动组织例如眼睛，心脏或移动胚胎或功能/低噪声成像的3D成像中，通过使用角配合或 极化。 还公开了一种在测量流动剖面中消除轴向运动效应的方法。

公开(公告)号：US07466423B2

公开(公告)日：2008-12-16

申请号：US11239677

申请日：2005-09-30

Applicant: Adrian Podoleanu ,  Adrian Bradu ,  Chris Dainty ,  David Merino

Inventor： Adrian Podoleanu ,  Adrian Bradu ,  Chris Dainty ,  David Merino

IPC: G01B9/02

CPC classification number: A61B3/102 ,  A61B3/1025 ,  A61B3/14

Abstract: Optical mapping apparatus for imaging an object, comprising an optical coherence tomography (OCT) system including an OCT source, an OCT reference path leading from the OCT source to an OCT receiver, an OCT object path leading from the object to the OCT coupler, an OCT depth scanner adapted to alter at least one of the OCT reference path and the OCT receiver path. A confocal system is provided including a confocal optical receiver a confocal path leading from the object to the confocal optical receiver via a confocal input aperture. An adaptive optics (AO) system is provided to correct optical aberrations in the OCT object path and the confocal path.

Abstract translation: 用于对物体成像的光学映射设备，包括包括OCT源，从OCT源引导到OCT接收器的OCT参考路径的光学相干断层摄影（OCT）系统，从对象引导到OCT耦合器的OCT对象路径， OCT深度扫描器适于改变OCT参考路径和OCT接收器路径中的至少一个。 提供了共焦系统，其包括共聚焦光学接收器，其经由共焦输入孔从物体引导到共焦光学接收器。 提供自适应光学（AO）系统来校正OCT对象路径和共焦路径中的光学像差。

公开(公告)号：US08514404B2

公开(公告)日：2013-08-20

申请号：US12919026

申请日：2009-02-24

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: G01B9/02 ,  G01B11/02

CPC classification number: G01B9/02014 ,  A61B3/102 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/7257 ,  G01B9/02002 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795

Abstract: The invention discloses an optical interferometer which can be used to provide simultaneous measurements over multiple path lengths and methods to employ such an interferometer as to achieve a variety of functions covering simultaneous measurements at different depths separated by an increment of a multiple differential delay matched in the interferometer as well as imaging. Optical sensors, optical coherence tomography (OCT) set-ups, optical sensing methods and OCT methods are disclosed which can provide: (i) multiple en-face images at several depths with dynamic dispersion compensation, (ii) fast acquisition of cross sections, (iii) fast acquisition of 3D volumes of a scattering object while maintaining dynamic focus; (iv) fast acquisition of long axial measurement profiles, non mechanical, with dynamic focus, range scalable, with applications in tracking and OTDR. Methods are disclosed on the combination of scanning regimes and modes of operation to achieve versatile functionality in measurements, in the 3D imaging of moving tissue such as the eye, heart, or moving embryos or functional/low noise imaging by making use of angular compounding or polarisation. A method for elimination of axial movement effects in measuring the flow profile is also disclosed.

Abstract translation: 本发明公开了一种光干涉仪，其可用于提供多路径长度上的同时测量以及采用这种干涉仪的方法，以实现各种功能，覆盖在不同深度处的同时测量，所述多个不同深度由在 干涉仪以及成像。 公开了光学传感器，光学相干断层扫描（OCT）设置，光学感测方法和OCT方法，其可以提供：（i）在几个深度处具有动态色散补偿的多个面部图像，（ii）快速获取横截面， （iii）快速获取散射物体的3D体积，同时保持动态聚焦; （iv）快速获取长轴向测量轮廓，非机械，具有动态聚焦，范围可扩展，应用于跟踪和OTDR。 在扫描方式和操作模式的组合中公开了方法，以在测量中进行多功能功能，在移动组织例如眼睛，心脏或移动胚胎或功能/低噪声成像的3D成像中，通过使用角配合或 极化。 还公开了一种在测量流动剖面中消除轴向运动效应的方法。

公开(公告)号：US07594730B2

公开(公告)日：2009-09-29

申请号：US11547922

申请日：2005-03-11

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: A61B3/00 ,  A61B3/02 ,  A61B3/10

CPC classification number: G01B9/02091 ,  A61B3/102 ,  G01B9/02083

Abstract: OCT cross section images of a part of a curved object are displayed by creating a series of image points and placing each image point into a corrected image in such a way that the positions of scattering points within the image coincide with or are at least closer to their real spatial distribution within the curved object.

Abstract translation: 通过创建一系列图像点并将每个图像点放置在校正图像中，使得图像内的散射点的位置与图像中的位置一致或至少更接近于图像点来显示弯曲物体的一部分的OCT截面图像 它们在曲线对象内的实际空间分布。

公开(公告)号：US20070046948A1

公开(公告)日：2007-03-01

申请号：US11239677

申请日：2005-09-30

Applicant: Adrian Podoleanu ,  Adrian Bradu ,  Chris Dainty ,  David Merino

Inventor： Adrian Podoleanu ,  Adrian Bradu ,  Chris Dainty ,  David Merino

IPC: G01B11/02

CPC classification number: A61B3/102 ,  A61B3/1025 ,  A61B3/14

Abstract: Optical mapping apparatus for imaging an object, comprising an optical coherence tomography (OCT) system including an OCT source, an OCT reference path leading from the OCT source to an OCT receiver, an OCT object path leading from the object to the OCT coupler, an OCT depth scanner adapted to alter at least one of the OCT reference path and the OCT receiver path. A confocal system is provided including a confocal optical receiver a confocal path leading from the object to the confocal optical receiver via a confocal input aperture. An adaptive optics (AO) system is provided to correct optical aberrations in the OCT object path and the confocal path.

Abstract translation: 用于对物体成像的光学映射设备，包括包括OCT源，从OCT源引导到OCT接收器的OCT参考路径的光学相干断层摄影（OCT）系统，从对象引导到OCT耦合器的OCT对象路径， OCT深度扫描器适于改变OCT参考路径和OCT接收器路径中的至少一个。 提供了共焦系统，其包括共聚焦光学接收器，其经由共焦输入孔从物体引导到共焦光学接收器。 提供自适应光学（AO）系统来校正OCT对象路径和共焦路径中的光学像差。

公开(公告)号：US08619184B2

公开(公告)日：2013-12-31

申请号：US12866304

申请日：2009-02-06

Applicant: Adrian Podoleanu

Inventor： Adrian Podoleanu

IPC: H04N5/225

CPC classification number: H04N5/232 ,  A61B3/102 ,  A61B3/14 ,  G01B9/02007 ,  G01B9/0203 ,  G01B9/02049 ,  G01B9/02069 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/70 ,  G02B21/0056 ,  G02B21/0064 ,  H04N5/2252 ,  H04N5/33

Abstract: An adapter which can make use of the devices in any commercially available digital cameras to accomplish different functions, the invention admits addition of confocal detection and provides simultaneous measurements or imaging in at least two channels, confocal and OCT, where the confocal channel provides an en-face image simultaneous with the acquisition of OCT cross sections, to guide the acquisition as well as to be used subsequently in the visualization of OCT images. Different technical solutions are provided for the assembly of one or two digital cameras which together with such adapters lead to modular and portable high resolution imaging systems which can accomplish various functions with a minimum of extra components while adapting the elements in the digital camera.

Abstract translation: 可以使用任何市售数码相机中的装置来实现不同功能的适配器，本发明允许加入共聚焦检测，并且在至少两个通道，共聚焦和OCT中提供同时测量或成像，其中共聚焦通道提供en 同时采集OCT横截面，以指导采集以及随后在OCT图像的可视化中使用。 提供了不同的技术解决方案，用于组装一个或两个数字照相机，这些数字照相机与这些适配器一起导致模块化和便携式的高分辨率成像系统，其可以在使数字照相机中的元件适应的同时以最小额外的成分完成各种功能。