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公开(公告)号：US10669314B2
公开(公告)日：2020-06-02
申请号：US15317188
申请日：2015-06-15
Applicant: Affibody AB
Inventor： Fredrik Frejd , Elin Gunneriusson , Ingmarie Höidén-Guthenberg , Per-Ake Nygren , Susanne Klint , Feifan Yu
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for interleukin-6, and provides an IL-6 binding polypeptide comprising the sequence EEX3X4AWX7EIH X11 LPNLX16X17X18QX20 X21AFIX25X26LX28X29. The present disclosure also relates to the use of such an IL-6 binding polypeptide as a therapeutic, prognostic and/or diagnostic agent.
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公开(公告)号：US10323066B2
公开(公告)日：2019-06-18
申请号：US15510900
申请日：2015-09-17
Applicant: Affibody AB
Inventor： Lars Abrahmsén , Caroline Ekblad , Elin Gunneriusson , Torbjörn Gräslund , Johan Seijsing , John Löfblom , Malin Lindborg , Fredrik Frejd , Lindvi Gudmundsdotter
IPC: C07K14/31 , C07K14/00 , C07K14/735 , C07K14/74 , A61K38/00
Abstract: The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal Fc receptor FcRn, and provides an FcRn binding dimer, comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein the first and second monomer units each comprises an FcRn binding motif. The FcRn binding dimer binds FcRn with higher capacity compared to the first monomer unit or second monomer unit alone. The present disclosure also relates to the use of the FcRn binding dimer as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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公开(公告)号：US20170114099A1
公开(公告)日：2017-04-27
申请号：US15317188
申请日：2015-06-15
Applicant: Affibody AB
Inventor： Fredrik Frejd , Elin Gunneriusson , Ingmarie Höidén-Guthenberg , Per-Ake Nygren , Susanne Klint , Feifan Yu
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for interleukin-6, and provides an IL-6 binding polypeptide comprising the sequence EEX3X4AWX7EIH X11 LPNLX16X17X18QX20 X21AFIX25X26LX28X29. The present disclosure also relates to the use of such an IL-6 binding polypeptide as a therapeutic, prognostic and/or diagnostic agent.
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公开(公告)号：US20160289337A1
公开(公告)日：2016-10-06
申请号：US14442603
申请日：2013-12-19
Applicant: AFFIBODY AB
Inventor： Lars Abrahmsén , Ingmarie Höidén-Guthenberg , Elin Gunneriusson
CPC classification number: C07K16/40 , C07K14/435 , C07K14/47 , C07K16/30 , C07K2317/92 , C07K2318/20
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for carbonic anhydrase IX (CAIX), and provides a CAIX binding polypeptide comprising the sequence EX2X3X4AX6X7EIX10X11LPN LX16X17X18QX20 X21AFIX25X26LWD. The present disclosure also relates to the use of such a CAIX binding polypeptide as a diagnostic, prognostic agent and/or therapeutic agent.
Abstract translation: 本公开还涉及这种CAIX结合多肽作为诊断，预后剂和/或治疗剂的用途。
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公开(公告)号：US20240139352A1
公开(公告)日：2024-05-02
申请号：US18119070
申请日：2023-03-08
Applicant: General Electric Company , Affibody AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
CPC classification number: A61K51/088 , C07K14/71
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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Patent Agency Ranking
公开(公告)号：US11155596B2
公开(公告)日：2021-10-26
申请号：US15770956
申请日：2016-10-28
Applicant: AFFIBODY AB
Inventor： Elisabet Wahlberg , Elin Gunneriusson
IPC: A61K38/00 , C07K14/705 , A61K38/16 , A61K38/17 , A61K38/36 , C07K14/745 , A61P35/00 , A61K47/42 , C07K14/47
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for programmed death-ligand 1 (PD-L1), and provides a PD-L1 binding polypeptide comprising the sequence ERNX4AAX7EIL X11LPNLX16X17X18QX20 WAFIWX26LX28D. The present disclosure also relates to the use of such a PD-L1 binding polypeptide as a therapeutic, prognostic and/or diagnostic agent.
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公开(公告)号：US20210047372A1
公开(公告)日：2021-02-18
申请号：US16977625
申请日：2019-03-12
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Sophia Hober , Sarah Lindbo
Abstract: The disclosure provides a population of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence Xsc1AELDXsc2Xsc3GVG AXXIKXIXsc4XA XXVEXVQXXK QXILAX. The disclosure also provides methods for selecting and identifying polypeptides from the population, as well as such polypeptides themselves.
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公开(公告)号：US20180230235A1
公开(公告)日：2018-08-16
申请号：US15938424
申请日：2018-03-28
Applicant: AFFIBODY AB
Inventor： Lars Abrahmsén , Ingmarie Höidén-Guthenberg , Elin Gunneriusson
IPC: C07K16/40 , C07K14/47 , C07K14/435 , C07K16/30
CPC classification number: C07K16/40 , C07K14/435 , C07K14/47 , C07K16/30 , C07K2317/92 , C07K2318/20
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for carbonic anhydrase IX (CAIX), and provides a CAIX binding polypeptide comprising the sequence EX2X3X4AX6X7EIX10X11LPN LX16X17X18QX20X21AFIX25X26LWD (SEQ ID NO. 369). The present disclosure also relates to the use of such a CAIX binding polypeptide as a diagnostic, prognostic agent and/or therapeutic agent.
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公开(公告)号：US11633507B2
公开(公告)日：2023-04-25
申请号：US17117697
申请日：2020-12-10
Applicant: General Electric Company , Affibody AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US09975943B2
公开(公告)日：2018-05-22
申请号：US14776319
申请日：2014-03-17
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Malin Lindborg , Lars Abrahmsen , John Löblom , Torbjörn Gräslund , Johan Seijsing
IPC: C07K14/745 , C07K14/735 , C07K14/74 , C07K14/31 , C07K14/435 , A61K38/00
CPC classification number: C07K14/745 , A61K38/00 , C07K14/31 , C07K14/435 , C07K14/70535 , C07K14/70539 , C07K2319/74
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2X3X4AX6X7 EIRWLPNL X16X17X18QRX21 AFIX25X26LX28X29 (SEQ ID NO: 1075). The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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