公开(公告)号：US20080167643A1

公开(公告)日：2008-07-10

申请号：US11791277

申请日：2005-11-21

申请人： Noam Mizrahi ,  Shimon Eckhouse ,  Alon Getz ,  Aharon Cohen ,  Fabian Izhack ,  Eran Levit

发明人： Noam Mizrahi ,  Shimon Eckhouse ,  Alon Getz ,  Aharon Cohen ,  Fabian Izhack ,  Eran Levit

IPC分类号： A61B18/04

CPC分类号： A61B18/082 ,  A61B2018/00005 ,  A61B2018/00404

摘要： An apparatus for treating varicose veins includes a catheter (20) where the distal end is placed within a varicose vein and the proximal portion remains outside the body of the subject. A heating element (22) heats the vein. A cooling element (62) can be applied to an external surface of the skin above the vicinity of the heating element. A control unit (26) can drive the heating element to apply heat to the vein simultaneously. Alternatively, the control unit can apply a current to the heating element to resistively heat a resistive element. A method for treating a varicose vein includes inserting the elongated heating element into the vein, and driving the heating element to apply heat to the segment of vein simultaneously from the entire active heating portion.

摘要翻译： 用于治疗静脉曲张的装置包括导管（20），其中远端放置在静脉曲张内并且近端部分保留在受试者的身体外部。 加热元件（22）加热静脉。 冷却元件（62）可以施加到加热元件附近的皮肤的外表面上。 控制单元（26）可以驱动加热元件同时对静脉施加热量。 或者，控制单元可以向加热元件施加电流以电阻加热电阻元件。 用于治疗静脉曲张的方法包括将细长的加热元件插入静脉中，并且驱动加热元件以从整个活动加热部分同时向静脉段施加热量。

公开(公告)号：US5084150A

公开(公告)日：1992-01-28

申请号：US566846

申请日：1990-08-14

申请人： Barry L. Karger ,  Aharon Cohen

发明人： Barry L. Karger ,  Aharon Cohen

IPC分类号： B01D15/08 ,  B01D57/02 ,  G01N30/02 ,  G01N30/28 ,  G01N30/58

CPC分类号： B01D57/02 ,  B01D15/08 ,  B01D15/3885 ,  G01N30/58 ,  G01N2030/285 ,  G01N30/02

摘要： An electrokinetic method for separating molecular species employs the surface of moving charged colloidal particles in a buffered dispersing medium, in a process which combines electrophoresis and a variant of chromatography in which the "stationary phase" surface moves. The colloidal particles have on their surface a material having the ability to interact selectively with the molecular species to be separated. The surface of the particles as originally formed may have such an ability, or the surface is modified to produce it. In one embodiment the colloidal particles are negatively charged and the surface-modifying materials are metal ions. In another embodiment the surface of the colloidal particles is modified by the incorporation of affinity groups. The analytes distribute themselves between the dispersing medium and the surface of the colloidal particles, resulting in analyte migration rates which are functions of the individual distribution equilibrium constants and the rate of colloidal particle migration. A capillary column for conducting the method includes surface-modified charged colloidal particles in a buffered dispersing medium.

摘要翻译： 用于分离分子种类的电动方法在组合电泳和“固定相”表面移动的色谱变体的过程中使用缓冲分散介质中移动带电胶体颗粒的表面。 胶体颗粒在其表面上具有能够与要分离的分子物质选择性相互作用的材料。 最初形成的颗粒的表面可以具有这样的能力，或者表面被修饰以产生它。 在一个实施方案中，胶体颗粒带负电荷，表面改性材料是金属离子。 在另一个实施方案中，通过引入亲和基团来修饰胶体颗粒的表面。 分析物分散在分散介质和胶体颗粒的表面之间，导致分析物迁移速率，其是单个分布平衡常数和胶体颗粒迁移速率的函数。 用于进行该方法的毛细管柱包括缓冲分散介质中的表面改性的带电胶体颗粒。

公开(公告)号：US20180085108A1

公开(公告)日：2018-03-29

申请号：US15275667

申请日：2016-09-26

申请人： Ofir Rimer ,  Nir Altman ,  Shalom Levin ,  Asaf Levin ,  Izhak Fabian ,  Aharon Cohen

发明人： Ofir Rimer ,  Nir Altman ,  Shalom Levin ,  Asaf Levin ,  Izhak Fabian ,  Aharon Cohen

IPC分类号： A61B17/04

CPC分类号： A61B17/0401 ,  A61B17/0469 ,  A61B17/068 ,  A61B2017/00309 ,  A61B2017/00323 ,  A61B2017/00327 ,  A61B2017/0409 ,  A61B2017/0464 ,  A61B2017/0648 ,  A61F2220/0016

摘要： A tacker for applying a rotary tack, including a tacker for applying a rotary tack, including a handle with a first trigger assembly and a second trigger assembly, the trigger assemblies being coupled to an articulated applicator arm which is disposed through a drive shaft connected to the handle, the first trigger assembly operative to apply a rotary tack from a distal end of the applicator arm and the second trigger assembly operative to bend the distal end of the applicator arm, wherein a longitudinal axis of the handle is tilted with respect to the drive shaft.

公开(公告)号：US08366706B2

公开(公告)日：2013-02-05

申请号：US12192911

申请日：2008-08-15

申请人： Maurice Buchbinder ,  Amnon Yadin ,  Noam Mizrahi ,  Shimon Eckhouse ,  Eran Goldberg ,  Aharon Cohen ,  Julie Logan

发明人： Maurice Buchbinder ,  Amnon Yadin ,  Noam Mizrahi ,  Shimon Eckhouse ,  Eran Goldberg ,  Aharon Cohen ,  Julie Logan

IPC分类号： A61B18/04

CPC分类号： B23P6/00 ,  A61B17/00491 ,  A61B17/0057 ,  A61B18/08 ,  A61B2017/00557 ,  A61B2017/00637 ,  A61B2017/00659 ,  A61B2017/22054 ,  A61B2017/22068 ,  Y10T137/598

摘要： Systems, apparatuses and methods are provided for use in closing punctures in vessel walls. An apparatus may have various combinations of an anchoring device, a positioning device and a heating element for closing a puncture within a vessel wall. An anchoring device may be a balloon, an expansible cage, a wire operated T-anchor, and/or a floating anchor. A positioning device may be a balloon, a sponge, and/or an expansible cage. A heating element may be flexible or rigid and preferably provides heat to target tissue through conduction and convection. A heating element may be flat-ended or dome-shaped. The heating element and anchoring device may be positioned a fixed distance apart to sandwich tissue between the heating element and the anchoring device. The heating element may operate in multiple stages. An initial stage may non-permanently adhere the heating element to the tissue and the subsequent stage may close the puncture.

摘要翻译： 提供系统，装置和方法用于封闭血管壁中的穿刺。 装置可以具有锚定装置，定位装置和加热元件的各种组合，用于封闭血管壁内的穿刺。 锚定装置可以是气球，可膨胀的笼，有线操作的T形锚和/或浮动锚。 定位装置可以是气球，海绵和/或可膨胀的笼。 加热元件可以是柔性的或刚性的，并且优选地通过传导和对流向目标组织提供热量。 加热元件可以是平的或圆顶形的。 加热元件和锚定装置可以定位成固定的距离，以夹在组合在加热元件和锚定装置之间。 加热元件可以在多个阶段中操作。 初始阶段可以非加热地将加热元件粘附到组织上，随后的阶段可以闭合穿刺。

公开(公告)号：US20100270354A1

公开(公告)日：2010-10-28

申请号：US12427778

申请日：2009-04-22

申请人： Ofir Rimer ,  Nir Altman ,  Shalom Levin ,  Asaf Levin ,  Izhak Fabian ,  Aharon Cohen

发明人： Ofir Rimer ,  Nir Altman ,  Shalom Levin ,  Asaf Levin ,  Izhak Fabian ,  Aharon Cohen

IPC分类号： A61B17/068

CPC分类号： A61B17/068 ,  A61B2017/0648 ,  A61B2017/2905 ,  A61B2017/2923 ,  A61B2017/2943

摘要： A tacker for applying a rotary tack, including a tacker for applying a rotary tack, including a handle with a first trigger assembly and a second trigger assembly, the trigger assemblies being coupled to an articulated applicator arm which is disposed through a drive shaft connected to the handle, the first trigger assembly operative to apply a rotary tack from a distal end of the applicator arm and the second trigger assembly operative to bend the distal end of the applicator arm, wherein a longitudinal axis of the handle is tilted with respect to the drive shaft.

摘要翻译： 一种用于施加旋转钉的粘合剂，包括用于施加旋转钉的粘合剂，其包括具有第一触发器组件的手柄和第二触发器组件，所述触发器组件联接到铰接的施用臂，所述铰接式施用臂通过连接到 所述手柄，所述第一触发器组件可操作以从所述施用器臂的远端施加旋转钉，并且所述第二触发器组件可操作以弯曲所述施用器臂的远端，其中所述手柄的纵向轴线相对于所述施加器臂倾斜 传动轴。

公开(公告)号：US4997537A

公开(公告)日：1991-03-05

申请号：US406080

申请日：1989-09-12

申请人： Barry L. Karger ,  Aharon Cohen

发明人： Barry L. Karger ,  Aharon Cohen

IPC分类号： G01N27/447

CPC分类号： G01N27/44747 ,  G01N27/44721 ,  G01N27/44752

摘要： A microcapillary column for high performance electrophoresis. A preferred column includes a microcapillary, a thin layer of coating material covalently bonded to the inner surface of the microcapillary wall, a thin layer of a hydrophilic polymer absorbed on the layer of coating material, and a gel comprising polyacrylamide polymerized in the tube, filling it. The gel-containing microcapillary is prepared by covalently bonding a layer of a suitable coating material to the inner surface of the microcapillary wall, applying a layer of hydrophilic polymer, and then causing a mixture of monomer with or without crosslinking agent, initiator, and polymerization catalyst to react in the bore of the microcapillary to form a polymeric matrix. In electrophoresis, the gel-containing microcapillary provides peak efficiencies in excess of 100,000 theoretical plates and in some instances over 1,000,000 theoretical plates within separation times of less than thirty minutes, permits trace level determinations of molecular weights, and permits electrophoretic operation at fields of 300 V/cm or higher, resulting in extremely high resolution separations.

摘要翻译： 用于高性能电泳的微毛细管柱。 优选的柱包括微毛细管，共价结合到微毛细管壁的内表面的薄层涂层材料，吸附在涂层材料层上的亲水性聚合物的薄层，以及包含在管中聚合的聚丙烯酰胺的凝胶，填充物 它。 含有凝胶的微毛细管通过将合适的涂层材料层共价键合到微毛细管壁的内表面，施加一层亲水聚合物，然后使单体与或不与交联剂，引发剂和聚合物 催化剂在微毛细孔的孔中反应以形成聚合物基质。 在电泳中，含凝胶的微毛细管提供超过100,000理论塔板的峰值效率，在某些情况下，在少于30分钟的分离时间内超过1,000,000理论塔板，允许痕量水平测定分子量，并允许电场操作在300 V / cm以上，导致极高的分辨率分离。