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公开(公告)号：US20080015160A1
公开(公告)日：2008-01-17
申请号：US11591480
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in pancreatic carcinoma as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在胰腺癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20070154916A1
公开(公告)日：2007-07-05
申请号：US11591486
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in myeloma as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经发现与正常细胞相比在骨髓瘤中扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US08216785B2
公开(公告)日：2012-07-10
申请号：US12568569
申请日：2009-09-28
申请人： Johji Inazawa , Issei Imoto , Jun Inoue
发明人： Johji Inazawa , Issei Imoto , Jun Inoue
CPC分类号： G01N33/57407 , A61K38/00 , C12Q1/6886 , C12Q2600/154
摘要： The present invention is intended to provide a means for judging the malignancy of neuroblastoma and the progress of spontaneous regression thereof. The present invention provides a method for detecting cancer which comprises detecting activation or inactivation of the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) gene and amplification of the MYCN gene in a specimens to evaluate the malignancy of the specimens and the progress of spontaneous regression.
摘要翻译： 本发明旨在提供一种判断神经母细胞瘤的恶性程度及其自发消退的方法。 本发明提供一种检测癌症的方法，其包括检测样品中溶酶体相关蛋白多能跨膜5（LAPTM5）基因的活化或失活以及MYCN基因的扩增，以评估标本的恶性程度和自发回归的进展 。
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公开(公告)号：US20070154915A1
公开(公告)日：2007-07-05
申请号：US11591470
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in large intestine cancer as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在大肠癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US08183223B2
公开(公告)日：2012-05-22
申请号：US12964464
申请日：2010-12-09
申请人： Johji Inazawa , Ken-ichi Kozaki , Issei Imoto
发明人： Johji Inazawa , Ken-ichi Kozaki , Issei Imoto
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/16 , C12Q2600/178 , Y10T436/143333
摘要： The present invention is directed to methods for suppressing the growth of oral squamous-cell carcinoma cells. The methods include introducing at least one gene selected from miR-137 or miR-193a into oral squamous-cell carcinoma cells.
摘要翻译： 本发明涉及抑制口腔鳞状细胞癌细胞生长的方法。 所述方法包括将至少一种选自miR-137或miR-193a的基因导入口腔鳞状细胞癌细胞。
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公开(公告)号：US20110076768A1
公开(公告)日：2011-03-31
申请号：US12964464
申请日：2010-12-09
申请人： Johji INAZAWA , Ken-ichi Kozaki , Issei Imoto
发明人： Johji INAZAWA , Ken-ichi Kozaki , Issei Imoto
IPC分类号： C12N5/02
CPC分类号： C12Q1/6886 , C12Q2600/154 , C12Q2600/16 , C12Q2600/178 , Y10T436/143333
摘要： An object of the present invention is to identify genes exhibiting characteristic behavior in the cases of carcinoma such as oral squamous-cell carcinoma using a change of expression level of micro RNA in oral squamous-cell carcinoma as an indicator, so as to provide a method for detecting carcinoma and an agent for suppressing carcinoma. The present invention A method for detecting oral squamous-cell carcinoma, which comprises detecting malignant transformation of specimens by employing a change of expression level of micro RNA as an indicator, and an agent for suppressing oral squamous-cell carcinoma using micro RNA.
摘要翻译： 本发明的目的在于鉴定使用口腔鳞状细胞癌中的微小RNA的表达水平的变化作为指标，在癌症例如口腔鳞状细胞癌的情况下表现出特征性的基因，以提供一种方法 用于检测癌症和抑制癌症的药剂。 本发明一种检测口腔鳞状细胞癌的方法，其特征在于，使用微RNA的表达水平的变化作为指标检测标本的恶性转化，以及使用微RNA抑制口腔鳞状细胞癌的药剂。
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公开(公告)号：US20090054245A1
公开(公告)日：2009-02-26
申请号：US11785683
申请日：2007-04-19
申请人： Hisashi Takada , Issei Imoto , Johji Inazawa
发明人： Hisashi Takada , Issei Imoto , Johji Inazawa
CPC分类号： C12Q1/6886 , C12Q2600/154
摘要： It is an objective of the present invention to provide a highly stable and reproducible method for detecting gastric cancer, by finding a novel gastric cancer-related gene and detecting the inactivation of such cancer-related gene. The present invention provides a method for detecting gastric cancer, comprising detecting malignant transformation of a gastric tissue cell by detecting the inactivation of the human VLDLR gene in the gastric tissue cell.
摘要翻译： 本发明的目的是提供一种用于检测胃癌的高度稳定和可重现的方法，通过发现新的胃癌相关基因并检测这种癌症相关基因的失活。 本发明提供了一种检测胃癌的方法，包括通过检测胃组织细胞中人VLDLR基因的失活来检测胃组织细胞的恶性转化。
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公开(公告)号：US09229003B2
公开(公告)日：2016-01-05
申请号：US12503434
申请日：2009-07-15
申请人： Johji Inazawa , Issei Imoto , Takaya Ishihara , Hitoshi Tsuda
发明人： Johji Inazawa , Issei Imoto , Takaya Ishihara , Hitoshi Tsuda
IPC分类号： C12Q1/68 , C12Q1/70 , C12P19/34 , G01N33/574
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： It is an object of the present invention to identify a gene that exhibits behavior which is characteristic of carcinomas such as thyroid carcinoma, so as to provide a method for detecting carcinoma and a cell growth suppressing agent. The present invention provides a method for detecting carcinoma, which comprises detecting malignant transformation by detecting at least one alteration of gene existing in chromosomal regions 1q41, 3q28, 7q31.2, 8p12, 8q22.2, 8q24.21, 11q4.1, 17q12, 20q11, 9p21.3, 16q13.2, and 16q23.1 in a specimen.
摘要翻译： 本发明的目的是鉴定表现出甲状腺癌等癌症特征的基因，从而提供检测癌症和细胞生长抑制剂的方法。 本发明提供了一种检测癌症的方法，其包括通过检测染色体区域1q41，3q28,7q31.2,8p12,8q22.2,8q24.21,11q4.1,17q12中存在的基因的至少一个改变来检测恶性转化 ，20q11,9p21.3,16q13.2和16q23.1。
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19.发明申请公开(公告)号：US20140018248A1
公开(公告)日：2014-01-16
申请号：US12730919
申请日：2010-03-24
申请人： Johji INAZAWA , Issei Imoto , Shuhei Komatsu , Ken-ichi Kozaki , Hitoshi Tsuda
发明人： Johji INAZAWA , Issei Imoto , Shuhei Komatsu , Ken-ichi Kozaki , Hitoshi Tsuda
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/118
摘要： An object of the present invention is to provide a method for detecting cancer and an agent for suppressing cell growth by identification of genes showing behaviors characteristic in cancer such as esophageal carcinoma. The present invention provides a method for detecting cancer, which comprises detecting canceration through detection of amplification of at least one gene existing in an 1q32-1q41 chromosomal region in a specimen.
摘要翻译： 本发明的目的是提供一种通过鉴定显示食管癌等癌症行为特征的基因来检测癌症的方法和抑制细胞生长的药剂。 本发明提供了一种检测癌症的方法，其包括通过检测样品中1q32-1q41染色体区域中存在的至少一个基因的扩增来检测癌变。
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公开(公告)号：US20100035262A1
公开(公告)日：2010-02-11
申请号：US12503434
申请日：2009-07-15
申请人： Johji Inazawa , Issei Imoto , Takaya Ishihara , Hitoshi Tsuda
发明人： Johji Inazawa , Issei Imoto , Takaya Ishihara , Hitoshi Tsuda
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/112 , C12Q2600/156
摘要： It is an object of the present invention to identify a gene that exhibits behavior which is characteristic of carcinomas such as thyroid carcinoma, so as to provide a method for detecting carcinoma and a cell growth suppressing agent. The present invention provides a method for detecting carcinoma, which comprises detecting malignant transformation by detecting at least one alteration of gene existing in chromosomal regions 1q41, 3q28, 7q31.2, 8p12, 8q22.2, 8q24.21, 11q4.1, 17q12, 20q11, 9p21.3, 16q13.2, and 16q23.1 in a specimen.
摘要翻译： 本发明的目的是鉴定表现出甲状腺癌等癌症特征的基因，从而提供检测癌症和细胞生长抑制剂的方法。 本发明提供了一种检测癌症的方法，其包括通过检测染色体区域1q41，3q28,7q31.2,8p12,8q22.2,8q24.21,11q4.1,17q12中存在的基因的至少一个改变来检测恶性转化 ，20q11,9p21.3,16q13.2和16q23.1。
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