利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

32 条记录 (耗时 0.035 秒)

    Imidazopyridines and related derivatives as selective modulators of bradykinin B2 receptors
    11.
    发明授权
    Imidazopyridines and related derivatives as selective modulators of bradykinin B2 receptors 失效
    咪唑并吡啶类和相关衍生物作为缓激肽B2受体的选择性调节剂

    公开(公告)号：US06420365B1

    公开(公告)日：2002-07-16

    申请号：US09765159

    申请日：2001-01-17

    申请人： John M. Peterson ,  Alan Hutchison ,  Kenneth Shaw ,  Kevin Hodgetts ,  George D. Maynard ,  Richard Lew

    发明人： John M. Peterson ,  Alan Hutchison ,  Kenneth Shaw ,  Kevin Hodgetts ,  George D. Maynard ,  Richard Lew

    IPC分类号： A61K31435

    CPC分类号： C07D471/04

    摘要： Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein A, B, C, D, Y, R1, R3, R4, R5, and R6 are variables defined herein, which compounds are modulators of Bradykinin B2 receptors. These compounds are useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatory disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility, glaucoma, pain, asthma, and rhinitis and for the increase of permeability of the blood-brain barrier or the blood-brain-tumor barrier.

    摘要翻译： 公开了下式的化合物或其药学上可接受的无毒性盐，其中A，B，C，D，Y，R 1，R 3，R 4，R 5和R 6是本文定义的变量，该化合物是缓激肽B2受体的调节剂 。 这些化合物可用于诊断和治疗肾脏疾病，心力衰竭，高血压，梅尼埃病，阴道炎症和疼痛，外周循环障碍，更年期障碍，视网膜循环障碍，心肌缺血，心肌梗死，心肌梗死后综合征，心绞痛， 经皮腔内冠状动脉血管成形术，肝炎，肝硬化，胰腺炎，肠梗阻，糖尿病，糖尿病并发症，男性不育症，青光眼，疼痛，哮喘和鼻炎的再狭窄，以及增加血脑屏障或血脑屏障的渗透性， 肿瘤屏障。

    Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors
    12.
    发明授权
    Aryl and hetroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors 失效
    芳基和杂芳基稠合氨基烷基 - 咪唑衍生物：缓激肽B2受体的选择性调节剂

    公开(公告)号：US06358949B1

    公开(公告)日：2002-03-19

    申请号：US09540580

    申请日：2000-03-31

    申请人： Robert W. DeSimone ,  Alan Hutchison ,  Kenneth Shaw ,  George D. Maynard ,  John M. Peterson ,  Richard Lew ,  Harry L. Brielmann

    发明人： Robert W. DeSimone ,  Alan Hutchison ,  Kenneth Shaw ,  George D. Maynard ,  John M. Peterson ,  Richard Lew ,  Harry L. Brielmann

    IPC分类号： A61K315377

    CPC分类号： C07D471/04

    摘要： Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein: A, B, C and D are N or CH; X is a bond or (un)substituted CH2; R1 is lower alkenyl or (un)substituted lower alkyl; R3 is lower alkyl; and R2, R4, R5, and R6 are variables defined herein; which compounds are useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatroy disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility or glaucoma, or for the increase of permeability of blood-brain barrier, pain, asthma, and rhinitis.

    摘要翻译： 公开了下式的化合物或其药学上可接受的无毒盐，其中：A，B，C和D是N或CH; X是一个或（un）取代的CH 2; R 1是低级烯基或（取代） 低级烷基; R3是低级烷基; 和R2，R4，R5和R6是本文定义的变量;这些化合物可用于诊断和治疗肾脏疾病，心力衰竭，高血压，梅尼埃病，阴道炎症和疼痛，外周循环障碍，更年期障碍，视网膜循环障碍， 心肌缺血，心肌梗死，心肌梗死后综合征，心绞痛，经皮腔内冠状动脉成形术后再狭窄，肝炎，肝硬化，胰腺炎，肠梗阻，糖尿病，糖尿病并发症，男性不育症或青光眼，或增加血脑屏障通透性 ，疼痛，哮喘和鼻炎。

    Surveillance balloon
    15.
    发明授权
    Surveillance balloon 失效
    监视气球

    公开(公告)号：US5115997A

    公开(公告)日：1992-05-26

    申请号：US464388

    申请日：1990-01-12

    申请人： John M. Peterson

    发明人： John M. Peterson

    IPC分类号： B64B1/20 ,  B64B1/50

    CPC分类号： B64B1/50 ,  B64B1/20

    摘要： A tethered surveillance balloon having a relatively low lift-to-weight ratio (e.g., 1.1) and an aerodynamic device to help maintain the surveillance balloon elevation when subject to high velocity wind conditions at an altitude which is a high percentage of the altitude the surveillance balloon would assume if there was zero wind velocity and all other conditions were the same (e.g. temperature, air density). The surveillance balloon also includes a sensing device such as a TV detector for detecting objects and relaying information to a ground station and with possibly a target designation device, if so desired. The balloon is formed of a material which is virtually, if not entirely, radar and visibly transparent.

    摘要翻译： 具有相对较低提升重量比（例如1.1）的系留式监视气球和一种空气动力学装置，以在高度为高度的高度风速条件下维持监视气球高度，高度是高度的高度监视 如果风速为零，所有其他条件相同（如温度，空气密度），气球就会假设。 监视气球还包括诸如TV检测器的感测装置，用于检测物体并将信息中继到地面站以及可能的目标指定装置，如果需要的话。 气球是由雷达实际上（如果不是完全）和明显透明的材料形成的。

    Non-combustible nuclear radiation shields with high hydrogen content
    16.
    发明授权
    Non-combustible nuclear radiation shields with high hydrogen content 失效
    具有高氢含量的不可燃核辐射屏蔽

    公开(公告)号：US4123392A

    公开(公告)日：1978-10-31

    申请号：US695378

    申请日：1976-06-14

    申请人： William C. Hall ,  John M. Peterson

    发明人： William C. Hall ,  John M. Peterson

    IPC分类号： G21F1/04 ,  G21F1/10 ,  C09K3/00

    CPC分类号： G21F1/106 ,  G21F1/045 ,  G21F1/047

    摘要： This invention relates to compositions, methods of production and uses of non-combustible nuclear radiation shields, with particular emphasis on those containing a high concentration of hydrogen atoms, especially effective for moderating neutron energy by elastic scatter, dispersed as a discontinuous phase in a continuous phase of a fire resistant matrix.

    摘要翻译： 本发明涉及不可燃核辐射屏蔽的组合物，生产方法和使用方法，特别强调含有高浓度氢原子的组合物，特别是对通过弹性散射调节中子能有效的氢能原子分散在连续的不连续相中 耐火基体的相。

    Method and system for through fault detection in electrical devices
    17.
    发明申请
    Method and system for through fault detection in electrical devices 有权
    电气设备中通过故障检测的方法和系统

    公开(公告)号：US20100208403A1

    公开(公告)日：2010-08-19

    申请号：US11991124

    申请日：2006-08-29

    申请人： Ratan Das ,  Sethuraman Ganesan ,  John M. Peterson

    发明人： Ratan Das ,  Sethuraman Ganesan ,  John M. Peterson

    IPC分类号： H02H3/00

    CPC分类号： H02H7/0455 ,  G01R19/2513 ,  G01R27/2694 ,  G01R31/027 ,  G01R31/34 ,  H02H3/006

    摘要： The present invention is directed to a method and a system for fault detection analysis in a power device which is operatively associated with a differential protection unit. The power device has one input side and one output side through which an input current and an output current flows into and out from it, respectively. Signals representative of the input and output currents are processed in order to verify if an occurring fault is external to the power device. Under a condition of an external fault, the differential protection unit is disabled for a determined interval of time.

    摘要翻译： 本发明涉及一种与差分保护单元可操作地相关联的功率器件中的故障检测分析的方法和系统。 功率器件具有一个输入侧和一个输出侧，输入电流和输出电流分别通过该输入侧和输出侧流入和流出。 处理代表输入和输出电流的信号，以验证发生故障是否在功率器件外部。 在外部故障的情况下，差动保护单元在一段确定的时间间隔内被禁用。