公开(公告)号：US08794013B2

公开(公告)日：2014-08-05

申请号：US13097724

申请日：2011-04-29

Applicant: Ying Zhou ,  Theodore H. Gasteyer, III ,  Nigel J. Grinter ,  Alan T. Cheng ,  Yeu-Chuan Simon Ho ,  Robert R. Sever

Inventor： Ying Zhou ,  Theodore H. Gasteyer, III ,  Nigel J. Grinter ,  Alan T. Cheng ,  Yeu-Chuan Simon Ho ,  Robert R. Sever

IPC: F25D25/00 ,  G01N1/22 ,  C12M3/00 ,  A01N1/02 ,  F25D3/10 ,  F25D29/00

CPC classification number: A01N1/0289 ,  A01N1/0257 ,  A01N1/0284 ,  F25D3/102 ,  F25D29/001

Abstract: A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.

Abstract translation: 提供了控制速率冷冻和成核的方法和系统。 本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力，其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。 生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。 目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。

公开(公告)号：US20140007615A1

公开(公告)日：2014-01-09

申请号：US13884647

申请日：2011-11-08

Applicant: Alan T. Cheng ,  De-Cheng Xie ,  Zhijie Sun

Inventor： Alan T. Cheng ,  De-Cheng Xie ,  Zhijie Sun

IPC: F25J3/00

CPC classification number: F25J3/00 ,  C01B33/035 ,  H02K21/38

Abstract: A system and method for improved cryogenic cooling of process streams in polysilicon manufacturing is provided. The disclosed system and method provides for the cryogenic cooling of a silane and hydrogen process stream during the manufacture of polysilicon with concurrent recovery of refrigeration capacity from the vaporized nitrogen as well as the recovery of refrigeration capacity from the cold hydrogen stream. The improved cryogenic cooling system and method reduces the overall consumption of liquid nitrogen without sacrificing cooling performance of the cryogenic cooling of the silane and hydrogen process stream.

Abstract translation: 提供了一种用于改善多晶硅制造中工艺流的低温冷却的系统和方法。 所公开的系统和方法提供了在制造多晶硅期间硅烷和氢工艺流的低温冷却，同时从蒸发的氮回收制冷能力以及从冷氢流回收制冷能力。 改进的低温冷却系统和方法降低了液氮的总体消耗，而不牺牲硅烷和氢气工艺流的低温冷却的冷却性能。

公开(公告)号：US20130323714A1

公开(公告)日：2013-12-05

申请号：US13908462

申请日：2013-06-03

Applicant: Alan T. Cheng ,  Ying Zhou ,  Paul W. Belanger ,  Jennifer G. Bugayong

Inventor： Alan T. Cheng ,  Ying Zhou ,  Paul W. Belanger ,  Jennifer G. Bugayong

IPC: C12M1/00

CPC classification number: C12M41/48 ,  C12M21/12 ,  C12M27/00 ,  C12M29/06 ,  C12M29/24 ,  C12M41/32 ,  C12M41/34

Abstract: A method and apparatus for micro-aeration of large scale fermentation systems is provided. The micro-aeration system includes a fermentation reactor, a sparging apparatus, and a micro-aeration gas mixture delivered to the fermentation reactor via the sparging apparatus. The micro-aeration gas mixture is a very low oxygen concentration mixture comprising an oxygen containing gas and an inert carrier gas that is preferably recycled through the fermentation reactor. The inert carrier gas is preferably nitrogen whereas the oxygen containing gas is oxygen or and is introduced to the fermentation reactor at a minimum superficial velocity of about 0.02 m/sec to produce a uniform dispersion of the oxygen/air throughout the fermentation broth while concurrently mixing the entire fermentation broth. The micro-aeration method and apparatus further comprises a controller operatively coupled to one or more control valves for regulating the micro-aeration conditions in the fermentation reactor.

Abstract translation: 提供了一种用于大规模发酵系统微通气的方法和装置。 微曝气系统包括通过喷射装置输送到发酵反应器的发酵反应器，喷射装置和微通气气体混合物。 微通气气体混合物是包含含氧气体和惰性载气的非常低的氧浓度混合物，其优选通过发酵反应器再循环。 惰性载气优选为氮气，而含氧气体为氧气，或以约0.02m / sec的最小表观速度引入发酵反应器，以产生氧气/空气在整个发酵液中的均匀分散，同时混合 整个发酵液。 微曝气方法和装置还包括操作地耦合到一个或多个控制阀的控制器，用于调节发酵反应器中的微通气条件。

公开(公告)号：US06355292B1

公开(公告)日：2002-03-12

申请号：US09492759

申请日：2000-01-27

Applicant: Alan T. Cheng ,  Pedro L. Durao

Inventor： Alan T. Cheng ,  Pedro L. Durao

IPC: C12G106

CPC classification number: A23L2/54

Abstract: The tendency of carbonated beverage to generate excessive foam when it is produced and bottled is reduced in a process including: (a) providing water or a mixture of water and syrup, which contains oxygen or air dissolved therein, and maintaining a pressure greater than atmospheric thereon; (b) saturating said mixture with carbon dioxide, and feeding the resultant mixture to step (c), while maintaining sufficient pressure thereon that no dissolved gas evolves therefrom; and (c) removing dissolved oxygen or air from the mixture formed in step (b) while dissolving additional carbon dioxide into said mixture and maintaining over said mixture a pressure greater than atmospheric.

Abstract translation: 碳酸饮料在生产和装瓶过程中产生过量泡沫的趋势在一个过程中减少，包括：（a）提供水或水和糖浆的混合物，其中含有溶解在其中的氧气或空气，并保持大于大气压 上; （b）用二氧化碳使所述混合物饱和，并将所得混合物进料至步骤（c），同时在其上保持足够的压力，不会从其中产生溶解气体; 和（c）从步骤（b）中形成的混合物中除去溶解的氧气或空气，同时将额外的二氧化碳溶解在所述混合物中并保持所述混合物的压力大于大气压。

公开(公告)号：US5302325A

公开(公告)日：1994-04-12

申请号：US587860

申请日：1990-09-25

Applicant: Alan T. Cheng

Inventor： Alan T. Cheng

IPC: B01F3/04 ,  B01F5/00 ,  B01F5/04 ,  B01F5/06

CPC classification number: B01F5/061 ,  B01F5/0416 ,  Y10S261/78

Abstract: The dispersion of a gas in a liquid is enhanced by accelerating a gas/liquid mixture to supersonic velocity, with subsequent deacceleration, in a conical in-line mixer.

Abstract translation: 通过在锥形在线混合器中将气体/液体混合物加速至超音速，随后进行减速，增强气体在液体中的分散。

公开(公告)号：US5061406A

公开(公告)日：1991-10-29

申请号：US587745

申请日：1990-09-25

Applicant: Alan T. Cheng

Inventor： Alan T. Cheng

IPC: B01F3/04 ,  B01F5/04 ,  B01J10/00 ,  B01J19/00 ,  B01J19/26

CPC classification number: B01F5/0416 ,  B01J10/002 ,  B01J19/006 ,  B01J19/26 ,  B01J2219/00162 ,  B01J2219/00774 ,  Y10S261/56 ,  Y10S261/75 ,  Y10S261/78

Abstract: The dispersion of a gas in a liquid is enhanced by the use of an adjustable conical mixer to control the flow of a gas/liquid mixture to a venturi device used to accelerate the mixture to a supersonic vclocity with subsequent deacceleration to subsonic velocity to produce sonic shock waves in the mixture.

公开(公告)号：US20120318017A1

公开(公告)日：2012-12-20

申请号：US13526614

申请日：2012-06-19

Applicant: Alan T. Cheng

Inventor： Alan T. Cheng

IPC: F25J1/02

CPC classification number: B01D7/00 ,  B01D5/0006 ,  B01D8/00 ,  B01D53/265 ,  B01D2256/10 ,  F25B39/04 ,  F28D7/0066 ,  F28D7/024

Abstract: A method and apparatus for condensing vapor in a gas. A cryogen, such as liquid nitrogen, may be provided into first and second coil sets in a condenser housing to cool the condensable vapor in the housing to condense the vapor into a liquid or solid form. The flow of cryogen in the first and second coil sets may be independently controlled, coils in the first and/or second coil sets may have a substantially equal length, and/or coils in the first and/or second coil sets may have uppermost portions that are located at a substantially equal height.

Abstract translation: 一种用于冷凝气体中的蒸气的方法和装置。 诸如液氮的冷冻剂可以设置在冷凝器壳体中的第一和第二线圈组中，以冷却壳体中的可冷凝蒸气以将蒸气冷凝成液体或固体形式。 可以独立地控制第一和第二线圈组中的冷冻剂的流动，第一和/或第二线圈组中的线圈可以具有基本相等的长度，和/或第一和/或第二线圈组中的线圈可以具有最高部分 它们位于基本上相等的高度。

公开(公告)号：US20120295333A1

公开(公告)日：2012-11-22

申请号：US13475239

申请日：2012-05-18

Applicant: Alan T. Cheng

Inventor： Alan T. Cheng

IPC: C12M1/04 ,  C12N1/14 ,  C12N1/16 ,  C12N1/20

CPC classification number: C12M23/28 ,  C12M23/14 ,  C12M23/48 ,  C12M29/06

Abstract: Biological liquid substances in a disposable bioreactor or a disposable fermentor is enriched with a dissolved gas such as oxygen. The gas is provided to the liquid in meeting growth needs of biomass within the disposable vessel. The liquid is processed through a bubble forming element such as a supersonic mixer, a membrane sparger, or the like, to form a gas-liquid dispersion. The dispersion has a high interfacial surface area for facilitating gas dissolution in the liquid. Receptacles of the disposable vessel may be coupled (e.g., magnetically) to one or more processing devices (e.g., motors, pumps, gas sources) outside of the disposable vessel so that components within the disposable vessel are able to perform functions suitable for furthering reaction and/or fermentation processes.

Abstract translation: 一次性生物反应器或一次性发酵罐中的生物液体物质富含溶解气体如氧气。 将气体提供给液体以满足一次性容器内生物质的生长需求。 液体通过诸如超声波混合器，隔膜喷雾器等的气泡形成元件加工以形成气液分散体。 分散体具有高的界面表面积，以便于气体溶解在液体中。 一次性容器的容器可以与一次性容器外部的一个或多个处理装置（例如，马达，泵，气体源）耦合（例如，磁性），使得一次性容器内的部件能够执行适于进一步反应的功能 和/或发酵过程。

公开(公告)号：US20120295332A1

公开(公告)日：2012-11-22

申请号：US13475163

申请日：2012-05-18

Applicant: Alan T. Cheng

Inventor： Alan T. Cheng

IPC: C12M1/06 ,  C12N1/00 ,  C12N1/14 ,  C12N1/20 ,  C12N1/16

CPC classification number: C12M23/28 ,  C12M23/14 ,  C12M27/04 ,  C12M27/06 ,  C12M29/06

Abstract: Oxygen is delivered into a liquid contained within a vessel. Oxygen-rich gas is introduced at an inner mixing region of a vessel toward an agitating element for dissolving some of the oxygen into the liquid. Air is introduced to the liquid at a location different from where the oxygen-rich gas is introduced, minimizing coalescing of bubbles of the oxygen-rich gas and air bubbles. Running the agitating element in the vessel may induce mixing of the liquid and improve oxygen dissolution. Movement of the air bubbles can also generate a mixing effect on the liquid, yet independent from mixing caused by the agitating element. In some embodiments, currents produced by the agitating element are asymmetric with respect to a vertical axis of the vessel. Air bubbles may also form an asymmetric configuration of bubbles about the vertical axis.

Abstract translation: 氧被输送到容纳在容器内的液体中。 在容器的内部混合区域将富氧气体引入用于将一些氧气溶解到液体中的搅拌元件。 在与富氧气体的引导位置不同的位置处将空气引入到液体中，使富氧气体和气泡的气泡的聚结最小化。 在容器中运行搅拌元件可能引起液体混合并改善氧气溶解。 气泡的移动也可以对液体产生混合效果，而与搅拌元件引起的混合无关。 在一些实施例中，由搅拌元件产生的电流相对于容器的垂直轴线是不对称的。 气泡也可以围绕垂直轴形成气泡的非对称构型。

公开(公告)号：US20120102977A1

公开(公告)日：2012-05-03

申请号：US13097763

申请日：2011-04-29

Applicant: Alan T. Cheng ,  Yeu-Chuan Simon Ho ,  Ying Zhou

Inventor： Alan T. Cheng ,  Yeu-Chuan Simon Ho ,  Ying Zhou

IPC: F17C5/02

CPC classification number: A01N1/0257 ,  A01N1/0284 ,  A01N1/0289 ,  F25D3/102 ,  F25D29/001

Abstract: A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.

Abstract translation: 提供了控制速率冷冻和成核的方法和系统。 本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力，其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。 生物材料的快速冷却是通过精确控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。 目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。