公开(公告)号：US20210077385A1

公开(公告)日：2021-03-18

申请号：US17024268

申请日：2020-09-17

Applicant: Alcon Inc.

Inventor： Junhao Ge ,  Steve Yun Zhang ,  Daqing Wu ,  Jing Cheng

IPC: A61K9/00 ,  A61K47/32 ,  A61K47/36 ,  A61K9/06 ,  A61K45/06

Abstract: The invention is generally related to a soft hydrogel ocular insert that is composed of at least one hydrogel material in fully hydrated state and can be comfortable for wearing. The hydrogel material comprises polymer chains, which are derived from at least one arylborono-containing hydrophilic copolymer and at least one mucoadhesive polymer, and cyclic boronic ester crosslinks for crosslinking those mucoadhesive polymer chains and arylborono-containing hydrophilic copolymer chains to form a 3-dimensional polymer network. Those cyclic boronic ester crosslinks can be hydrolyzed slowly in the tear of the eyes of a patient, resulting in the disintegration (dissolution) of the 3-dimensional polymer network and thereby providing mucoadhesisve polymers and optionally drugs impregnated in the hydrogel ocular insert in a controlled manner.

公开(公告)号：US20210009762A1

公开(公告)日：2021-01-14

申请号：US17038293

申请日：2020-09-30

Applicant: Alcon Inc.

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Junhao Ge ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G77/14 ,  C08L83/10 ,  G02B1/04 ,  C08G77/12 ,  B29D11/00 ,  G02C7/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US20190300654A1

公开(公告)日：2019-10-03

申请号：US16365973

申请日：2019-03-27

Applicant: Alcon Inc.

Inventor： Daqing Wu ,  Steve Yun Zhang ,  Junhao Ge ,  Richard Charles Breitkopf ,  Augustine Twum Kumi ,  Weihong Lang

IPC: C08G77/442 ,  G02B1/04 ,  B29D11/00

Abstract: The invention provides a method for making silicone hydrogel contact lenses. The method of the invention is characterized by using an organic solvent as a processing-aid tool for controlling lens diameter without significantly affecting lens equilibrium water content during cast-molding of soft contact lenses from a polymerizable composition. By adjusting the weight percentage of the organic solvent in a polymerizable composition for making SiHy contact lenses, one can adjust lens diameter of produced SiHy lenses to meet target without affecting adversely the lens properties.

公开(公告)号：US20240293985A1

公开(公告)日：2024-09-05

申请号：US18586910

申请日：2024-02-26

Applicant: Alcon Inc.

Inventor： Richard Charles Breitkopf ,  Feng Jing ,  Daqing Wu ,  Jack W. Trieu ,  Steve Yun Zhang

IPC: B29D11/00 ,  B29C33/40 ,  B29C35/02 ,  B29K83/00 ,  B29K105/00 ,  B29K105/16 ,  G02C7/04

CPC classification number: B29D11/00865 ,  B29C33/40 ,  B29C35/0227 ,  B29D11/00067 ,  B29D11/00125 ,  B29K2083/00 ,  B29K2105/0002 ,  B29K2105/0061 ,  B29K2105/16 ,  B29K2823/12 ,  B29K2995/0093 ,  G02C7/049

Abstract: The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner. The method comprises treating the molding surfaces of polypropylene lens molds (or other hydrophobic plastic molds) with a vacuum UV or a corona plasma to increase the surface energies of the molding surfaces of the lens molds, cast-molding a silicone hydrogel lens formulation containing a relatively small amount of at least one carboxyl-containing vinylic monomer in the treated lens molds, and heating resultant cast-molded silicone hydrogel contact lenses in an aqueous coating solution comprising a water-soluble and thermally crosslinkable polymeric material to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel layer covalently attached onto the bulk silicone hydrogel material.

公开(公告)号：US11945181B2

公开(公告)日：2024-04-02

申请号：US17512431

申请日：2021-10-27

Applicant: Alcon Inc.

Inventor： Junhao Ge ,  Yuan Chang ,  Steve Yun Zhang ,  Michelle Plavnik ,  Augustine Twum Kumi ,  Daqing Wu

IPC: B29D11/00 ,  C08F230/08 ,  G02C7/04 ,  G02C7/10 ,  B29K33/00 ,  B29K83/00 ,  B29K105/00

CPC classification number: B29D11/00653 ,  B29D11/00076 ,  B29D11/00134 ,  C08F230/08 ,  G02C7/04 ,  G02C7/102 ,  B29K2033/26 ,  B29K2083/00 ,  B29K2105/0002 ,  B29K2105/0061 ,  B29K2823/10 ,  B29K2995/0046 ,  B29K2995/0065

Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10hλ) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10hλ−20)° C. to about T10hλ° C. for a first curing time and maintaining a second curing temperature of from about (T10hλ+10)° C. to about (T10hλ+35)° C. for a second curing time.

公开(公告)号：US20230103231A1

公开(公告)日：2023-03-30

申请号：US17823539

申请日：2022-08-31

Applicant: Alcon Inc.

Inventor： Daqing Wu ,  Feng Jing ,  Steve Yun Zhang ,  Junhao Ge ,  Jack W. Trieu

IPC: G02B1/04 ,  G02B1/14 ,  B29D11/00

Abstract: The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermally or actinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C1-C2 alkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and/or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.

公开(公告)号：US11439661B2

公开(公告)日：2022-09-13

申请号：US16911833

申请日：2020-06-25

Applicant: ALCON INC.

Inventor： Steve Yun Zhang ,  Richard Charles Breitkopf ,  Daqing Wu ,  Junhao Ge ,  Maria F. Gubitosi Raspino ,  Augustine Twum Kumi ,  Wei Liang

IPC: A61K31/80 ,  A61P27/04 ,  A61K31/015 ,  A61K31/07 ,  A61K31/122 ,  A61K31/202 ,  A61K31/355 ,  A61K31/593 ,  A61K31/736 ,  A61K45/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

Abstract: The invention is generally related to topical ophthalmic compositions comprising: from about 0.05 w/v % to about 5 w/v % of galactomannan polymer; a cis-diol and about 0.5 w/v % to about 10 w/v % of a hydrophilic copolymer which comprises (a) arylborono-containing repeating units each having a boronic acid, (b) repeating units of at least one phosphorylcholine-containing vinylic monomer, and (c) acrylic monomeric units of at least one acrylic monomer having 3 to 16 carbon atoms, the ophthalmic composition is substantially free of a borate for improving lubrication, hydration and drug delivery property.

公开(公告)号：US20220275154A1

公开(公告)日：2022-09-01

申请号：US17742559

申请日：2022-05-12

Applicant: Alcon Inc.

Inventor： Steve Yun Zhang ,  Daqing Wu ,  Junhao Ge ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/20 ,  C08G77/388 ,  C08G77/392 ,  C08G77/14 ,  C08L83/10 ,  G02B1/04 ,  C08G77/12 ,  B29D11/00 ,  G02C7/04

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US11346982B2

公开(公告)日：2022-05-31

申请号：US17038266

申请日：2020-09-30

Applicant: Alcon Inc.

Inventor： Daqing Wu ,  Junhao Ge ,  Steve Yun Zhang ,  Richard Charles Breitkopf ,  Xinming Qian ,  Zach Munoz ,  Matthew D. Nelson ,  Augustine Twum Kumi ,  Weihong Lang ,  Ying Zheng ,  Feng Jing ,  Frank Chang

IPC: G02B1/04 ,  C08L83/04 ,  C08F230/08 ,  B29D11/00

Abstract: The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

公开(公告)号：US20210130648A1

公开(公告)日：2021-05-06

申请号：US17146181

申请日：2021-01-11

Applicant: Alcon Inc.

Inventor： Yongxing Qiu ,  Newton T. Samuel ,  John Dallas Pruitt ,  Chandana Kolluru ,  Arturo Norberto Medina ,  Lynn Cook Winterton ,  Daqing Wu ,  Xinming Qian ,  Jared Nelson

IPC: C09D177/06 ,  B29D11/00 ,  G02B1/04 ,  G02C7/04 ,  G02B1/10 ,  G02B1/18 ,  C08J7/04 ,  C08L83/04 ,  C08G77/388 ,  C08J5/00 ,  C09D5/16 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02

Abstract: The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.