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    Method for producing silicone hydrogel contact lenses
    3.
    发明授权
    Method for producing silicone hydrogel contact lenses 有权

    公开(公告)号：US11254076B2

    公开(公告)日：2022-02-22

    申请号：US16429811

    申请日：2019-06-03

    Applicant: Alcon Inc.

    Inventor： Junhao Ge ,  Daqing Wu ,  Richard Charles Breitkopf ,  Steve Yun Zhang ,  Augustine Twum Kumi

    IPC: B29D11/00 ,  C08F226/10 ,  G02B1/04 ,  B29K83/00 ,  B29K105/00

    Abstract: The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. A method of the invention comprising the steps of formulating a lens formulation by dissolving/blending all polymerizable components in a mixture a hydrophobic acrylic monomer as a reactive diluent and an organic solvent as a non-reactive diluent at a weight ratio of least 0.24 (reactive diluent over the sum of reactive and non-reactive solvents) per gram of the polymerizable composition and using a relatively low ultrasonic vibration energy for delensing. This method of the invention can be easily implemented in a production environment for enhancing the production yield.

    COATED SILICONE HYDROGEL CONTACT LENSES AND METHOD FOR MAKING THE SAME
    5.
    发明申请
    COATED SILICONE HYDROGEL CONTACT LENSES AND METHOD FOR MAKING THE SAME 有权

    公开(公告)号：US20240393501A1

    公开(公告)日：2024-11-28

    申请号：US18670852

    申请日：2024-05-22

    Applicant: Alcon Inc.

    Inventor： Jack W. Trieu ,  Daqing Wu ,  Feng Jing ,  Steve Yun Zhang

    IPC: G02B1/04 ,  C07F5/02 ,  G02B1/10

    Abstract: The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner. The method comprises obtaining a preformed silicone hydrogel contact lens comprising a bulk silicone hydrogel material that comprises repeating units of at least one carboxyl-containing vinylic monomer and at least one arylborono-containing vinylic monomer, and heating the preformed silicone hydrogel contact lens in an aqueous coating solution comprising a water-soluble and thermally crosslinkable polymeric material having azetidinium or epoxide groups and a diol-containing hydrophilic polymer having 1,2- or 1,3-diol moieties to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel coating that comprises a crosslinked polymeric material covalently attached onto the bulk silicone hydrogel material and a grafted diol-containing hydrophilic polymer covalently attached onto the bulk silicone hydrogel material and distributed in the crosslinked polymeric material.

    METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES
    7.
    发明申请
    METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES 有权

    公开(公告)号：US20220126541A1

    公开(公告)日：2022-04-28

    申请号：US17512431

    申请日：2021-10-27

    Applicant: Alcon Inc.

    Inventor： Junhao Ge ,  Yuan Chang ,  Steve Yun Zhang ,  Michelle Plavnik ,  Augustine Twum Kumi ,  Daqing Wu

    IPC: B29D11/00 ,  G02C7/04 ,  G02C7/10 ,  C08F230/08

    Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10hλ) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10hλ−20)° C. to about T10hλ° C. for a first curing time and maintaining a second curing temperature of from about (T10hλ+10)° C. to about (T10hλ+35)° C. for a second curing time.

    Wet-packed soft hydrogel ocular inserts
    9.
    发明授权
    Wet-packed soft hydrogel ocular inserts 有权

    公开(公告)号：US11931454B2

    公开(公告)日：2024-03-19

    申请号：US17024268

    申请日：2020-09-17

    Applicant: Alcon Inc.

    Inventor： Junhao Ge ,  Steve Yun Zhang ,  Daqing Wu ,  Jing Cheng

    IPC: A61K45/06 ,  A61K9/00 ,  A61K9/06 ,  A61K47/32 ,  A61K47/36

    CPC classification number: A61K9/0051 ,  A61K9/06 ,  A61K45/06 ,  A61K47/32 ,  A61K47/36

    Abstract: The invention is generally related to a soft hydrogel ocular insert that is composed of at least one hydrogel material in fully hydrated state and can be comfortable for wearing. The hydrogel material comprises polymer chains, which are derived from at least one arylborono-containing hydrophilic copolymer and at least one mucoadhesive polymer, and cyclic boronic ester crosslinks for crosslinking those mucoadhesive polymer chains and arylborono-containing hydrophilic copolymer chains to form a 3-dimensional polymer network. Those cyclic boronic ester crosslinks can be hydrolyzed slowly in the tear of the eyes of a patient, resulting in the disintegration (dissolution) of the 3-dimensional polymer network and thereby providing mucoadhesisve polymers and optionally drugs impregnated in the hydrogel ocular insert in a controlled manner.

    Method for producing silicone hydrogel contact lenses
    10.
    发明授权
    Method for producing silicone hydrogel contact lenses 有权

    公开(公告)号：US11254075B2

    公开(公告)日：2022-02-22

    申请号：US16429853

    申请日：2019-06-03

    Applicant: Alcon Inc.

    Inventor： Richard Charles Breitkopf ,  Daqing Wu ,  Junhao Ge ,  Steve Yun Zhang

    IPC: B29D11/00 ,  B29C35/02 ,  B29L11/00 ,  G02C7/04

    Abstract: The invention provides a contact lens manufacturing method comprising a process for removing unprocessed molded silicone hydrogel contact lenses from mold halves in a relatively efficient and consistent manner. A method of the invention comprises the combination of using a hydrophilic (meth)acrylamido monomer as one of major polymerizable components in a lens formulation for cast-molding of contact lenses, adding a post-curing treatment step which involves heating molds with molded lenses therewithin in an oven at a post-curing temperature higher than the curing temperature and under nitrogen gas flow at a higher flow rate, and using ultrasonic vibration energy for delensing. This method of the invention can be easily implemented in a production environment for enhancing the production yield.

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