公开(公告)号：US20240309196A1

公开(公告)日：2024-09-19

申请号：US18605027

申请日：2024-03-14

申请人： Pranav Soman ,  Puskal Kunwar

发明人： Pranav Soman ,  Puskal Kunwar

IPC分类号： C08L33/26 ,  B29C35/08 ,  B29C64/124 ,  B29C64/209 ,  B29C64/245 ,  B29C64/268 ,  B29C64/295 ,  B29K33/00 ,  B29K105/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/20 ,  B33Y70/00 ,  C08J3/075

CPC分类号： C08L33/26 ,  B29C64/124 ,  B29C64/245 ,  B29C64/268 ,  B29C64/295 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/20 ,  B33Y70/00 ,  C08J3/075 ,  B29C2035/0838 ,  B29C64/209 ,  B29K2033/26 ,  B29K2105/0002 ,  B29K2105/0061 ,  C08J2333/26 ,  C08J2405/00

摘要： An apparatus and method for shaping double-network hydrogels into customized 3D structures. A one-pot prepolymer formulation containing photo-cross-linkable acrylamide and thermoreversible sol-gel κ-carrageenan with a suitable crosslinker, and photo-initiator/absorbers was used. The formulation was polymerized using a TOPS system with heating stage to photo-polymerize the primary acrylamide network into a 3D structure above the sol-gel transition of κ-carrageenan (80° C.). Cooling down then generates the secondary physical κ-carrageenan network to realize tough double-network hydrogel structures. Printed 3D structures had superior lateral (37 μm) and vertical (180 μm) resolutions and 3D design freedoms (internal voids) that exhibit ultimate stress and strain of 200 kPa and 2400% respectively under tension, and simultaneously exhibit high compression stress of 15 MPa with a strain of 95%, both with high recovery rates. The apparatus and method can be employed with other double-network hydrogels to make multifunctional soft devices for a range of applications.

公开(公告)号：US11925569B1

公开(公告)日：2024-03-12

申请号：US16666192

申请日：2019-10-28

申请人： Arrowhead Center, Inc.

发明人： Robyn Marks ,  Reza Foudazi ,  Neda Sanatkaran ,  Ryan Zowada

IPC分类号： A61F2/78 ,  A61F2/30 ,  B29C39/00 ,  B29C39/02 ,  B29C44/34 ,  B29C44/56 ,  B29K33/00 ,  B29K33/04 ,  C08F2/32

CPC分类号： A61F2/7812 ,  B29C39/003 ,  B29C39/026 ,  B29C44/3403 ,  B29C44/56 ,  C08F2/32 ,  A61F2002/30024 ,  A61F2002/7818 ,  A61F2002/7837 ,  B29K2033/04 ,  B29K2033/26

摘要： A material that can be formed into a porous prosthetic sleeve liner that provides particularly useful benefits for prosthetics. The material is breathable and sweat-absorbing, thus minimizing skin morbidity when used as a prosthetic liner. The material can include hydrophilic-lined continuous pores within a hydrophobic polymer, wherein the hydrophilic lining is crosslinked together with the hydrophobic polymer via non-degradable covalent interactions using chain crosslinkers.

公开(公告)号：US20230366102A1

公开(公告)日：2023-11-16

申请号：US18315659

申请日：2023-05-11

申请人： Northern Technologies International Corporation

发明人： Mahin Shahlari ,  Mitchell Fillbach

IPC分类号： C23F11/14 ,  C08L33/26 ,  B29C48/08

CPC分类号： C23F11/145 ,  C08L33/26 ,  B29C48/08 ,  B29K2033/26

摘要： A volatile corrosion inhibitor composition comprising about 1 wt. % to about 100 wt. % of a polyacrylamide is disclosed that prevents corrosion of metal materials. A volatile corrosion inhibitor composition may also include a second volatile corrosion inhibitor selected from the group consisting of: ammonium salt, triazole, nitrite, nitrate, an amine carboxylate, an amine, a carboxylic acid, aldehyde, anhydride and any combination thereof. An anticorrosion method of a metal material using the volatile corrosion inhibitor composition is also disclosed.

公开(公告)号：US09752116B2

公开(公告)日：2017-09-05

申请号：US15235422

申请日：2016-08-12

申请人： The Curators of the University of Missouri ,  MUSC Foundation for Research Development

发明人： Gabor Forgacs ,  Karoly Jakab ,  Adrian Neagu ,  Vladimir Mironov

IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N5/07 ,  C12N11/00 ,  C12N11/12 ,  C12N5/071 ,  C12M1/26 ,  B29C67/00 ,  C12M3/00 ,  C12M1/00 ,  C12M1/36 ,  B33Y70/00 ,  B33Y10/00 ,  B33Y50/02 ,  B33Y30/00 ,  B33Y80/00 ,  B29L31/00 ,  B29K105/00 ,  B29K33/00

CPC分类号： C12N5/0062 ,  B29C64/112 ,  B29C64/209 ,  B29C64/386 ,  B29C64/393 ,  B29K2033/26 ,  B29K2105/0035 ,  B29K2105/0061 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y70/00 ,  B33Y80/00 ,  C12M21/08 ,  C12M33/12 ,  C12M41/48 ,  C12M47/00 ,  C12M47/02 ,  C12N5/0697

摘要： A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing processes parameters for use in producing an engineered tissue having a desired three-dimensional structure.

公开(公告)号：US20170028641A1

公开(公告)日：2017-02-02

申请号：US15272878

申请日：2016-09-22

申请人： SEIKO EPSON CORPORATION

发明人： Eiji OKAMOTO

IPC分类号： B29C67/00

CPC分类号： B29C33/448 ,  B29C64/112 ,  B29C64/20 ,  B29C64/40 ,  B29K2033/26 ,  B29K2105/0005 ,  B29K2105/0032 ,  B29K2105/0058 ,  B29L2009/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  C09D11/101 ,  C09D11/322 ,  C09D11/40 ,  Y10T428/24802

摘要： A three-dimensional shaped article manufacturing apparatus is an apparatus for manufacturing a three-dimensional shaped article by laminating layers formed by discharging and curing inks including a curable resin. The apparatus comprises: a first discharge unit configured to discharge a substantive section-forming ink to a region that forms the three-dimensional shaped article; a second discharge unit configured to discharge a sacrificial layer-forming ink for forming a sacrificial layer to a region that is adjacent to a region that forms an outermost layer of the three-dimensional shaped article and on a surface side of the outermost layer; and a curing unit configured to cure the substantive section-forming ink and the sacrificial layer-forming ink. A viscoelasticity of the sacrificial layer-forming ink during curing of the substantive section-forming ink being not less than a viscoelasticity of the substantive section-forming ink during curing of the substantive section-forming ink.

摘要翻译： 三维成形制品装置是一种通过层压由包含可固化树脂的油墨排出和固化形成的层来制造三维成形制品的装置。 该装置包括：第一排出单元，其构造成将实质的部分形成油墨排出到形成三维成形制品的区域; 第二放电单元，被配置为将用于形成牺牲层的牺牲层形成用墨水排出到与形成所述三维成形制品的最外层的区域相邻的区域以及所述最外层的表面侧; 以及固化单元，其被配置为固化所述实心部分形成油墨和所述牺牲层形成油墨。 在实施段形成油墨的固化过程中，牺牲层形成油墨的粘弹性不小于实体段形成油墨固化期间的实质段形成油墨的粘弹性。

公开(公告)号：US20160355676A1

公开(公告)日：2016-12-08

申请号：US15208873

申请日：2016-07-13

申请人： Applied Medical Resources Corporation

发明人： Natasha Felsinger ,  Sam Chehayeb ,  Eduardo Bolanos

IPC分类号： C08L33/26 ,  G09B23/30 ,  B29C39/00 ,  C08J5/12

CPC分类号： C08L33/26 ,  A61B18/12 ,  B29C39/003 ,  B29K2005/00 ,  B29K2033/26 ,  C08J5/122 ,  C08J2333/26 ,  C08J2405/04 ,  G09B23/30

摘要： A surgical simulator for electrosurgical training and simulation is provided. The surgical simulator includes one or more simulated tissue structures made substantially of a hydrogel comprising a dual interpenetrating network of ionically cross-linked alginate and covalently cross-linked acrylamide. Combinations of different simulated tissue structures define procedural-based models for the practice of various electrosurgical procedures including laparoscopic total mesorectal excision, transanal total mesorectal excision, cholecystectomy and transanal minimally invasive surgery. Methods of making the simulated tissue structures are also provided.

摘要翻译： 提供了一种用于电外科训练和模拟的手术模拟器。 手术模拟器包括基本由水凝胶制成的一个或多个模拟组织结构，其包含离子交联的藻酸盐和共价交联的丙烯酰胺的双互穿网络。 不同模拟组织结构的组合定义了用于各种电外科手术操作的基于程序的模型，包括腹腔镜全直肠切除术，经肛门全直肠切除术，胆囊切除术和经肛门微创手术。 还提供了制作模拟组织结构的方法。

公开(公告)号：US20150030642A1

公开(公告)日：2015-01-29

申请号：US14383490

申请日：2012-05-25

申请人： Feipeng Wu ,  Yuanhua Miao

发明人： Feipeng Wu ,  Yuanhua Miao

IPC分类号： A61K39/145 ,  A61K9/00 ,  B29C39/02 ,  A61K38/28 ,  C12N7/00 ,  C08F120/56 ,  A61M37/00 ,  A61K38/38

CPC分类号： A61K39/145 ,  A61K9/0021 ,  A61K38/28 ,  A61K38/385 ,  A61K47/32 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C39/026 ,  B29K2033/26 ,  B29K2901/00 ,  C08F120/56 ,  C08L33/26 ,  C12N7/00 ,  C12N2760/16034

摘要： The invention discloses a polymer micro-needle array chip, comprising a substrate and a micro-needle array standing thereon; the material for preparing the micro-needle array is a polyacrylamides polymer, with the molecular weight of 1.0×104-2.0×105, the Vickers hardness of 150-600 HV, and the impact strength of 5-30 J/m. The polymer micro-needle array chip has a high mechanical strength and a sharp needle tip, and it can easily dissolve or swell on contact with a water-containing environment, which helps the drug to be released slowly in the skin.

摘要翻译： 本发明公开了一种聚合物微针阵列芯片，其包括基板和站立在其上的微针阵列; 制备微针阵列的材料是聚丙烯酰胺聚合物，分子量为1.0×104-2.0×105，维氏硬度为150-600HV，冲击强度为5-30J / m。 聚合物微针阵列芯片具有高机械强度和锋利的针尖，并且在与含水环境接触时容易溶解或溶胀，这有助于药物在皮肤中缓慢释放。

公开(公告)号：US08480941B2

公开(公告)日：2013-07-09

申请号：US12879492

申请日：2010-09-10

申请人： Ralf Wehrspohn ,  Martin Steinhart

发明人： Ralf Wehrspohn ,  Martin Steinhart

IPC分类号： B29C41/02

CPC分类号： C03C23/0095 ,  B29C65/64 ,  B29C66/05 ,  B29C66/30326 ,  B29C66/341 ,  B29C66/71 ,  B29C66/712 ,  B29C66/7392 ,  B29C66/7394 ,  B29C66/742 ,  B29C66/7461 ,  B29C66/7465 ,  B29C66/91411 ,  B29C66/919 ,  B29C66/91921 ,  B29C66/91933 ,  B29K2023/06 ,  B29K2025/00 ,  B29K2027/18 ,  B29K2033/08 ,  B29K2067/00 ,  B29K2069/00 ,  B29K2071/00 ,  B29K2083/00 ,  B29K2105/045 ,  B29K2305/10 ,  B29K2305/12 ,  B29K2305/14 ,  B29K2309/04 ,  B29K2309/08 ,  B29L2031/3406 ,  B29L2031/756 ,  Y10T428/249921 ,  Y10T428/249978 ,  B29K2081/06 ,  B29K2081/00 ,  B29K2079/08 ,  B29K2077/00 ,  B29K2075/00 ,  B29K2067/006 ,  B29K2067/003 ,  B29K2065/00 ,  B29K2033/26 ,  B29K2025/06 ,  B29K2023/38 ,  B29K2023/083 ,  B29K2023/00 ,  B29K2011/00 ,  B29K2009/00

摘要： A three-dimensional molded body, a method for producing a three-dimensional molded body and a method for producing an adhesive bond between a polymer-containing material and a molded body having an inorganic porous framework structure in at least partial areas are described. In all cases the porous structure of the molded body comprising inorganic material is brought in contact with a polymer-containing material which is heated until the heated material enters into a joint connection with the molded body based on adhesive interactions, interfacial interactions, electrostatic interactions or any combination thereof, in which the pore-like voids of the porous structure are filled completely with the polymer-containing material, which stabilizes the molded body so that it has dimensional stability after cooling.

摘要翻译： 描述了三维成型体，三维成型体的制造方法以及含有聚合物的材料与至少部分区域中具有无机多孔骨架结构的成型体之间的粘结剂的制造方法。 在所有情况下，包含无机材料的成型体的多孔结构与含聚合物的材料接触，所述材料被加热直到加热的材料基于粘合剂相互作用，界面相互作用，静电相互作用或与其成为接合连接 其中多孔结构的孔状空隙完全被含聚合物的材料填充的任何组合，这使得成型体稳定，使得其在冷却后具有尺寸稳定性。

公开(公告)号：US20120288938A1

公开(公告)日：2012-11-15

申请号：US13529172

申请日：2012-06-21

申请人： Gabor Forgacs ,  Karoly Jakab ,  Adrian Neagu ,  Vladimir Mironov

发明人： Gabor Forgacs ,  Karoly Jakab ,  Adrian Neagu ,  Vladimir Mironov

IPC分类号： C12N5/02

CPC分类号： C12N5/0062 ,  B29C64/112 ,  B29C64/209 ,  B29C64/386 ,  B29C64/393 ,  B29K2033/26 ,  B29K2105/0035 ,  B29K2105/0061 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y70/00 ,  B33Y80/00 ,  C12M21/08 ,  C12M33/12 ,  C12M41/48 ,  C12M47/00 ,  C12M47/02 ,  C12N5/0697

摘要： A composition comprising a plurality of cell aggregates for use in producing engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension, extruding the resulting pellet through an orifice, and cutting the extruded pellet into pieces. Apparatus for making cell aggregates comprises an extrusion system and a cutting system. In a method of organ printing, a plurality of cell aggregates are embedded in a polymeric or gel matrix and allowed to fuse to form a desired three-dimensional tissue structure. An intermediate product comprises at least one layer of matrix and a plurality of cell aggregates embedded therein in a predetermined pattern. Modeling methods predict the structural evolution of fusing cell aggregates for combinations of cell type, matrix, and embedding patterns to enable selection of organ printing process parameters for use in producing an engineered tissue having a desired three-dimensional structure.

摘要翻译： 一种组合物，其包含用于通过器官印刷生产工程化器官组织的多个细胞聚集体。 制备多个细胞聚集体的方法包括离心细胞悬浮液，通过孔口挤出所得颗粒，并将挤出的颗粒切割成块。 用于制造细胞聚集体的装置包括挤出系统和切割系统。 在器官印刷的方法中，将多个细胞聚集体嵌入聚合物或凝胶基质中并使其融合以形成所需的三维组织结构。 中间产品包含至少一层矩阵和以预定图案嵌入其中的多个细胞聚集体。 建模方法预测用于细胞类型，基质和嵌入图案组合的融合细胞聚集体的结构演变，以便能够选择用于生产具有所需三维结构的工程组织的器官印刷工艺参数。

公开(公告)号：US08075835B2

公开(公告)日：2011-12-13

申请号：US11394668

申请日：2006-03-29

申请人： Richard W. Campbell ,  Noel J. Tessier

发明人： Richard W. Campbell ,  Noel J. Tessier

IPC分类号： B29C51/08 ,  B29C51/20

CPC分类号： C08J9/32 ,  B29C49/04 ,  B29C51/04 ,  B29K2023/06 ,  B29K2023/12 ,  B29K2025/00 ,  B29K2027/06 ,  B29K2033/26 ,  B29K2069/00 ,  B29K2075/00 ,  B29K2077/00 ,  B29K2101/12 ,  B29K2105/0085 ,  B29K2105/04 ,  B29K2105/16 ,  B29K2105/165 ,  B29L2031/7132 ,  C08J2203/22 ,  C08J2377/02 ,  Y10T428/249953

摘要： The present invention provides an improved syntactic foam plug for plug assist thermoforming wherein such plug is composed of a thermoplastic material having a relatively high melting and/or glass transition temperature. Accordingly, the subject invention encompasses diminishing or removing the undesirable characteristics of thermoset syntactic plugs while increasing the ease by which these articles may be constructed for a given use, by forming such plugs from syntactic foams containing thermoplastics.

摘要翻译： 本发明提供了一种用于插头辅助热成型的改进的复合泡沫塞，其中这种塞子由具有较高熔融和/或玻璃化转变温度的热塑性材料组成。 因此，本发明包括减少或去除热固性句法插塞的不期望的特性，同时通过从包含热塑性塑料的合成泡沫形成这种塞子，增加了可以为给定用途构建这些制品的容易程度。