公开(公告)号：US20240293985A1

公开(公告)日：2024-09-05

申请号：US18586910

申请日：2024-02-26

Applicant: Alcon Inc.

Inventor： Richard Charles Breitkopf ,  Feng Jing ,  Daqing Wu ,  Jack W. Trieu ,  Steve Yun Zhang

IPC: B29D11/00 ,  B29C33/40 ,  B29C35/02 ,  B29K83/00 ,  B29K105/00 ,  B29K105/16 ,  G02C7/04

CPC classification number: B29D11/00865 ,  B29C33/40 ,  B29C35/0227 ,  B29D11/00067 ,  B29D11/00125 ,  B29K2083/00 ,  B29K2105/0002 ,  B29K2105/0061 ,  B29K2105/16 ,  B29K2823/12 ,  B29K2995/0093 ,  G02C7/049

Abstract: The invention provides a method for producing coated silicone hydrogel contact lenses in a cost-effective manner. The method comprises treating the molding surfaces of polypropylene lens molds (or other hydrophobic plastic molds) with a vacuum UV or a corona plasma to increase the surface energies of the molding surfaces of the lens molds, cast-molding a silicone hydrogel lens formulation containing a relatively small amount of at least one carboxyl-containing vinylic monomer in the treated lens molds, and heating resultant cast-molded silicone hydrogel contact lenses in an aqueous coating solution comprising a water-soluble and thermally crosslinkable polymeric material to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a hydrogel layer covalently attached onto the bulk silicone hydrogel material.

公开(公告)号：US11945895B2

公开(公告)日：2024-04-02

申请号：US17199158

申请日：2021-03-11

Applicant: Alcon Inc.

Inventor： Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang ,  Weihong Lang

IPC: C08F283/12 ,  C08G77/06 ,  C08G77/388 ,  C08G77/442 ,  C08L83/08 ,  C08L83/12 ,  C09K9/02 ,  G02B1/04

CPC classification number: C08F283/124 ,  C08G77/06 ,  C08G77/388 ,  C08G77/442 ,  C08L83/08 ,  C08L83/12 ,  C09K9/02 ,  G02B1/043 ,  C08G2210/00 ,  C08L2312/06 ,  C09K2211/1088 ,  G02B2207/109

Abstract: The invention provides a class of photochromic polydiorganosiloxane vinylic crosslinkers. Each of the photochromic polydiorganosiloxane vinylic crosslinkers of the invention comprise (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and photochromic siloxane unit having one methyl substituent and one organic substituent having a photochromic moiety that capable of undergoing a reversible color change upon exposure to UV-irradiation or high-energy-violet light; (2) two terminal ethylenically-unsaturated groups. The invention also provides a soft photochromic contact lens, especially a photochromic silicone hydrogel contact lens, which comprises a crosslinked polymeric material comprising repeating units of at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers. The invention further provides a method of producing a photochromic contact lens from a polymerizable composition comprising at least one of such a class of photochromic polydiorganosiloxane vinylic crosslinkers.

公开(公告)号：US11945181B2

公开(公告)日：2024-04-02

申请号：US17512431

申请日：2021-10-27

Applicant: Alcon Inc.

Inventor： Junhao Ge ,  Yuan Chang ,  Steve Yun Zhang ,  Michelle Plavnik ,  Augustine Twum Kumi ,  Daqing Wu

IPC: B29D11/00 ,  C08F230/08 ,  G02C7/04 ,  G02C7/10 ,  B29K33/00 ,  B29K83/00 ,  B29K105/00

CPC classification number: B29D11/00653 ,  B29D11/00076 ,  B29D11/00134 ,  C08F230/08 ,  G02C7/04 ,  G02C7/102 ,  B29K2033/26 ,  B29K2083/00 ,  B29K2105/0002 ,  B29K2105/0061 ,  B29K2823/10 ,  B29K2995/0046 ,  B29K2995/0065

Abstract: Described herein is a method for producing photochromic silicone hydrogel contact lenses in a relatively efficient and consistent manner from a polymerizable composition under a controlled thermal curing scheme. The main polymerizable components in the polymerizable composition are a high radical-reactive hydrophilic (meth)acrylamido monomer, a high radical-reactive siloxane-containing (meth)acrylamido monomer, and a polysiloxane vinylic crosslinker(s) free of low-reactive ethylenically unsaturated group as the main crosslinker. The thermal free radical initiator having a 10 hour half-life temperature (T10hλ) of from about 50° C. to about 90° C. The controlled thermal curing scheme includes maintaining a first curing temperature of from about (T10hλ−20)° C. to about T10hλ° C. for a first curing time and maintaining a second curing temperature of from about (T10hλ+10)° C. to about (T10hλ+35)° C. for a second curing time.

公开(公告)号：US11886045B2

公开(公告)日：2024-01-30

申请号：US17518423

申请日：2021-11-03

Applicant: Alcon Inc.

Inventor： Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang ,  Michelle Plavnik ,  Augustine Twum Kumi

IPC: G02C7/04 ,  B29D11/00 ,  C08J7/18 ,  G02B1/04 ,  G02C7/10

CPC classification number: G02C7/049 ,  B29D11/00048 ,  C08J7/18 ,  G02B1/043 ,  G02C7/102 ,  C08J2300/00 ,  C08J2451/00

Abstract: Described herein is a method for producing photochromic contact lenses, in particular, photochromic silicone hydrogel contact lenses. The method comprises a step of cast molding of a lens-forming composition including an iniferter to form an unprocessed contact lens having iniferter moieties covalently incorporated into its polymer matrix and a step of iniferter-induced graft-polymerization of a photochromic vinylic monomer to the polymer matrix only in its central region which is circular and concentric with the central axis of the unprocessed contact lens. The obtained photochromic contact lens has a central pupillary region that only can undergo a reversible color change upon exposure to UV/HEVL-radiation.

公开(公告)号：US11840035B2

公开(公告)日：2023-12-12

申请号：US18165653

申请日：2023-02-07

Applicant: Alcon Inc.

Inventor： Richard Charles Breitkopf ,  Changhong Yin ,  Steve Yun Zhang

IPC: B29D11/00 ,  C08L83/04 ,  G02B1/04

CPC classification number: B29D11/00903 ,  C08L83/04 ,  G02B1/043

Abstract: The invention relates to a pad printing instrument comprising an ink supply system capable of control the temperature, viscosity and colorant concentration of an ink in an ink cup. Such controls are achieved by continuously adding and mixing a cold ink having a composition identical to the ink in the ink cup but having a lower temperature. The continuous addition of a small amount of a cold ink into the ink cup could compensate heat generated by the friction between the ink cup and a cliché and could minimize the evaporation of a diluent in the ink and change in the concentration of colorants in the ink and ink viscosity. The invention also relates to use of a pad printing instrument comprising an ink supply system of the invention for producing colored hydrogel or silicone hydrogel contact lenses.

公开(公告)号：US20230382065A1

公开(公告)日：2023-11-30

申请号：US18322651

申请日：2023-05-24

Applicant: Alcon Inc.

Inventor： Jing Cheng ,  Michelle Plavnik ,  Ya-Wen Chang ,  Feng Jing ,  Steve Yun Zhang

IPC: B29D11/00

CPC classification number: B29D11/00134 ,  B29D11/00442 ,  B29D11/0048

Abstract: A method for producing embedded hydrogel contact lenses comprises at least the following steps: obtaining an insert made of a crosslinked polymeric material comprising repeating units of a free-radical photoinitiator; placing the insert in a female lens mold half; dosing an amount of a lens-forming composition to immerse the insert in the female lens mold half; closing tightly a male lens mold half onto the top of the female lens mold half halves to form a molding assembly; actinically curing both the lens-forming composition in the molding assembly to form an embedded hydrogel lens precursor which comprises a bulk hydrogel material formed the lens-forming composition and the insert that is embedded therein and covalently linked to the bulk hydrogel material.

公开(公告)号：US11618823B2

公开(公告)日：2023-04-04

申请号：US17205186

申请日：2021-03-18

Applicant: Alcon Inc.

Inventor： Jing Cheng ,  Steve Yun Zhang

IPC: C08L83/06 ,  C08F220/12 ,  C08G77/442 ,  C08G77/20 ,  G02B1/04

Abstract: The invention is generally related to an insert for being embedded in a silicone hydrogel contact lens. The insert is made of a crosslinked materials which are rigid in dry state at room temperature (from about 22° C. to about 26° C.), have a high oxygen permeability and a high refractive index in fully hydrated state. Such materials are useful for making inserts in embedded contact lenses for correcting corneal astigmatism, presbyopia, and color blindness lenses and for imparting photochromic characteristics to the lenses. The invention is also related to a method for making embedded silicone hydrogel contact lenses comprising an insert of the invention therein and to embedded silicone hydrogel contact lenses comprising an insert of the invention therein.

公开(公告)号：US20230103231A1

公开(公告)日：2023-03-30

申请号：US17823539

申请日：2022-08-31

Applicant: Alcon Inc.

Inventor： Daqing Wu ,  Feng Jing ,  Steve Yun Zhang ,  Junhao Ge ,  Jack W. Trieu

IPC: G02B1/04 ,  G02B1/14 ,  B29D11/00

Abstract: The invention provide a method for producing coated silicone hydrogel contact lenses in a cost-effective and environmentally friendly manner. The method is free of lens extraction step and comprises: curing thermally or actinically in a lens mold a polymerizable composition that comprises at least one hydrophilized polysiloxane vinylic crosslinker, hydroxyethyl methacrylate, C1-C2 alkoxyethyl (meth)acrylate, at least one free-radical initiator, and at least one solvent selected from the group consisting of water, propylene glycol, and/or a low-molecular weight polyethyleneglycol; and heating the cast-molded silicone hydrogel contact lens in an aqueous coating solution to form a coated silicone hydrogel contact lens comprising a bulk silicone hydrogel material and a layer of a crosslinked hydrophilic polymeric material that is covalently attached onto the bulk silicone hydrogel material. Resultant contact lenses are optically clear and wettable and have a relatively high oxygen permeability.

公开(公告)号：US11513257B2

公开(公告)日：2022-11-29

申请号：US17122109

申请日：2020-12-15

Applicant: Alcon Inc.

Inventor： Ying Zheng ,  Jang-Shing Chiou ,  Jinbo Dou ,  Yuan Chang ,  Junhao Ge ,  Steve Yun Zhang ,  Li Yao ,  Karen Belinda Sentell ,  Ye Hong

IPC: C08L39/06 ,  G02B1/04 ,  B65B25/00 ,  C08L71/02 ,  C08L83/04 ,  G02C7/04

Abstract: The invention relates to an ophthalmic product which comprises a sealed and autoclave-sterilized lens package including (1) a post-autoclave packaging solution containing a polymeric surfactant having an HLB value of from about 11 to about 16 and a Mn of from about 800 to about 20,000 Daltons and (2) a readily-usable silicone hydrogel (SiHy) contact lens immersed in the packaging solution. The readily-usable SiHy contact lens comprises the polymeric surfactant thereon providing an excellent wettability to the readily-usable SiHy contact lens directly out of the lens package, and also the leachable polymeric surfactant which is physically distributed in the polymer matrix of the SiHy contact lens and can be released to the eye of a patient for at least 7 days of daily wear and to replenish the lens surface-bound polymeric surfactant to provide sustainable wettabilities to the contact lens and the eye.

公开(公告)号：US11453736B2

公开(公告)日：2022-09-27

申请号：US17038349

申请日：2020-09-30

Applicant: Alcon Inc.

Inventor： Jinyu Huang ,  Frank Chang ,  Steve Yun Zhang ,  Feng Jing

IPC: C08L101/14 ,  C08L83/04 ,  C08F290/06 ,  G02B1/04 ,  C08G77/20 ,  C08G77/16 ,  C08G77/392 ,  C08G77/12

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.