公开(公告)号：US20090193532A1

公开(公告)日：2009-07-30

申请号：US12099459

申请日：2008-04-08

申请人： Alejandro Abuin ,  Joel A. Edwards ,  Charles Montgomery ,  Carolina Rangel ,  Arthur T. Sands ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Brian Zambrowicz

发明人： Alejandro Abuin ,  Joel A. Edwards ,  Charles Montgomery ,  Carolina Rangel ,  Arthur T. Sands ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Brian Zambrowicz

IPC分类号： A01K67/027

CPC分类号： A01K67/0276 ,  A01K2217/075

摘要： The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The invention also relates to antibodies raised in a mouse of the invention. The invention further provides methods for using the mice, cells, polynucleotides, polypeptides and antibodies of the invention.

公开(公告)号：US20100233153A1

公开(公告)日：2010-09-16

申请号：US12375662

申请日：2007-10-01

申请人： Mark Dominic Borromeo ,  Jaime-Jo Cunningham ,  Frederick Desauvage ,  Ellen Filvaroff ,  Mark Alan Klamer ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Carolina Rangel ,  Zheng-Zheng Shi ,  Peter Vogel

发明人： Mark Dominic Borromeo ,  Jaime-Jo Cunningham ,  Frederick Desauvage ,  Ellen Filvaroff ,  Mark Alan Klamer ,  Laurie Jeanette Minze ,  Bobby Joe Payne ,  Carolina Rangel ,  Zheng-Zheng Shi ,  Peter Vogel

IPC分类号： A61K39/395 ,  C12N5/10 ,  C07K16/00 ,  A61K49/00 ,  A61P37/02 ,  A61P27/02 ,  A61P25/00 ,  A61P19/00 ,  A61P17/00 ,  A61P1/16 ,  A61P35/00 ,  A61P9/10 ,  A61P9/00 ,  A61P5/18 ,  C12Q1/02 ,  A01K67/00

CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A61K49/0008

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO1105, PRO1279 or PRO1783 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供包含PRO1105，PRO1279或PRO1783基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20120174239A1

公开(公告)日：2012-07-05

申请号：US13317754

申请日：2011-10-27

申请人： Stephen Jay Anderson ,  Jane Brennan ,  Frederic J. de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Nelda A. Fikes ,  Wenhu Huang ,  Wenjun Ouyang ,  Carolina Rangel ,  Mamta Sangha ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joseph Trackey ,  Melissa Vetter ,  Ching-Yun Wang ,  Jessica Woodings

发明人： Stephen Jay Anderson ,  Jane Brennan ,  Frederic J. de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Nelda A. Fikes ,  Wenhu Huang ,  Wenjun Ouyang ,  Carolina Rangel ,  Mamta Sangha ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joseph Trackey ,  Melissa Vetter ,  Ching-Yun Wang ,  Jessica Woodings

IPC分类号： G01N21/64 ,  G01N23/083 ,  C40B30/04 ,  G01N33/53

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes.Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20070292438A1

公开(公告)日：2007-12-20

申请号：US10583466

申请日：2004-12-13

申请人： Stephen Anderson ,  Jane Brennan ,  Frederic de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Nelda Fikes ,  Wenhu Huang ,  Wenjun Ouyang ,  Carolina Rangel ,  Mamta Sangha ,  Zheng-Zheng Shi ,  Mary Sparks ,  Joseph Trackey ,  Melissa Vetter ,  Ching-Yun Wang ,  Jessica Woodings

发明人： Stephen Anderson ,  Jane Brennan ,  Frederic de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Nelda Fikes ,  Wenhu Huang ,  Wenjun Ouyang ,  Carolina Rangel ,  Mamta Sangha ,  Zheng-Zheng Shi ,  Mary Sparks ,  Joseph Trackey ,  Melissa Vetter ,  Ching-Yun Wang ,  Jessica Woodings

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N5/00 ,  C12N5/06 ,  C12Q1/02 ,  G01N33/00

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。