公开(公告)号：US20120174239A1

公开(公告)日：2012-07-05

申请号：US13317754

申请日：2011-10-27

申请人： Stephen Jay Anderson ,  Jane Brennan ,  Frederic J. de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Nelda A. Fikes ,  Wenhu Huang ,  Wenjun Ouyang ,  Carolina Rangel ,  Mamta Sangha ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joseph Trackey ,  Melissa Vetter ,  Ching-Yun Wang ,  Jessica Woodings

发明人： Stephen Jay Anderson ,  Jane Brennan ,  Frederic J. de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Nelda A. Fikes ,  Wenhu Huang ,  Wenjun Ouyang ,  Carolina Rangel ,  Mamta Sangha ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joseph Trackey ,  Melissa Vetter ,  Ching-Yun Wang ,  Jessica Woodings

IPC分类号： G01N21/64 ,  G01N23/083 ,  C40B30/04 ,  G01N33/53

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes.Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20070292438A1

公开(公告)日：2007-12-20

申请号：US10583466

申请日：2004-12-13

申请人： Stephen Anderson ,  Jane Brennan ,  Frederic de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Nelda Fikes ,  Wenhu Huang ,  Wenjun Ouyang ,  Carolina Rangel ,  Mamta Sangha ,  Zheng-Zheng Shi ,  Mary Sparks ,  Joseph Trackey ,  Melissa Vetter ,  Ching-Yun Wang ,  Jessica Woodings

发明人： Stephen Anderson ,  Jane Brennan ,  Frederic de Sauvage ,  Zhiyong Ding ,  Joel Edwards ,  Nelda Fikes ,  Wenhu Huang ,  Wenjun Ouyang ,  Carolina Rangel ,  Mamta Sangha ,  Zheng-Zheng Shi ,  Mary Sparks ,  Joseph Trackey ,  Melissa Vetter ,  Ching-Yun Wang ,  Jessica Woodings

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N5/00 ,  C12N5/06 ,  C12Q1/02 ,  G01N33/00

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20110097330A1

公开(公告)日：2011-04-28

申请号：US11722967

申请日：2006-02-27

申请人： Allison Anne Byers Horner ,  Catherine Batac Clarke ,  Katherin E. Combs ,  Frederic J. de Sauvage ,  Joel Edwards ,  Paul Godowski ,  Deanna Grant Wilson ,  Wenhu Huang ,  Lorelei Diane Ketcherside ,  Erin Marie Massey ,  Charles Montgomery ,  Bobby Joe Payne ,  Andrew Peterson ,  Ni Nancy Qian ,  Jeffrey J. Schrick ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Colleen M. Viator ,  Peter Vogel ,  Weilan Ye ,  Jung-Hua Yeh ,  Zhiyong Ding

发明人： Allison Anne Byers Horner ,  Catherine Batac Clarke ,  Katherin E. Combs ,  Frederic J. de Sauvage ,  Joel Edwards ,  Paul Godowski ,  Deanna Grant Wilson ,  Wenhu Huang ,  Lorelei Diane Ketcherside ,  Erin Marie Massey ,  Charles Montgomery ,  Bobby Joe Payne ,  Andrew Peterson ,  Ni Nancy Qian ,  Jeffrey J. Schrick ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Joy Anne Stala ,  Colleen M. Viator ,  Peter Vogel ,  Weilan Ye ,  Jung-Hua Yeh ,  Zhiyong Ding

IPC分类号： A61K49/00 ,  C07K16/18 ,  A61K39/00 ,  A61P25/00 ,  A61P9/00 ,  A61P37/00 ,  A61P27/02 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P27/06 ,  A61P27/12 ,  A61P9/10 ,  A61P19/02 ,  A61P19/10 ,  C12Q1/68 ,  C12N5/071 ,  C12N5/0735 ,  C12Q1/02

CPC分类号： C07K14/47 ,  A01K2217/075 ,  A61K2039/505 ,  G01N2500/00

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供转基因小鼠，其包括PRO179，PRO181，PRO244，PRO247，PRO269，PRO293，PRO298，PRO339，PRO341，PRO347，PRO531，PRO537，PRO718，PRO773，PRO860，PRO871，PRO872，PRO813，PRO828，PRO1100中的中断 ，PRO1114，PRO115，PRO1126，PRO1133，PRO1154，PRO1185，PRO1194，PRO1287，PRO1291，PRO1293，PRO1310，PRO1312，PRO1335，PRO1339，PRO2155，PRO1356，PRO1385，PRO1412，PRO1487，PRO1758，PRO1779，PRO1785，PRO1889，PRO90318，PRO3434 ，PRO3579，PRO4322，PRO4343，PRO4347，PRO4403，PRO4976，PRO260，PRO6014，PRO6027，PRO6181，PRO6714，PRO9922，PRO7179，PRO7476，PRO9824，PRO19814，PRO19836，PRO20088，PRO70789，PRO50298，PRO51592，PRO1757，PRO4421，PRO9903，PRO1106 ，PRO1411，PRO1486，PRO1565，PRO4399或PRO4404基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20080160034A1

公开(公告)日：2008-07-03

申请号：US11572702

申请日：2005-08-23

申请人： Jane Brennan ,  Frederic J. de Sauvage ,  Weilan Ye ,  Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Bobby Joe Payne ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel

发明人： Jane Brennan ,  Frederic J. de Sauvage ,  Weilan Ye ,  Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Bobby Joe Payne ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel

IPC分类号： A61K39/395 ,  A01K67/00 ,  C12N5/06 ,  A61P27/02 ,  C07K16/18 ,  G01N33/567

CPC分类号： A01K67/0276 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/02 ,  A01K2267/03 ,  C12N15/8509

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245, PRO246, PRO258, PRO287, PRO328, PRO344, PRO357, PRO526, PRO724, PRO731, PRO732, PRO1003, PRO1104, PRO1151, PRO1244, PRO1298, PRO1313, PRO1570, PRO1886, PRO1891, PRO4409, PRO5725, PRO5994, PRO6097, PRO7425, PRO10102, PRO10282, PRO61709 or PRO779 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供转基因小鼠，其包括PRO196，PRO217，PRO231，PRO236，PRO245，PRO246，PRO258，PRO287，PRO328，PRO344，PRO357，PRO526，PRO724，PRO731，PRO732，PRO1003，PRO1104，PRO1151，PRO1244，PRO1298中的中断 ，PRO1313，PRO1570，PRO1886，PRO1891，PRO4409，PRO5725，PRO5994，PRO6097，PRO7425，PRO10102，PRO10282，PRO61709或PRO779基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20110093960A1

公开(公告)日：2011-04-21

申请号：US12907655

申请日：2010-10-19

申请人： Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Oox

发明人： Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Oox

IPC分类号： G01N33/00 ,  G01N33/48 ,  C12Q1/02 ,  C12Q1/68

CPC分类号： A01K67/0276 ,  A01K2217/054 ,  A01K2227/105 ,  A01K2267/03 ,  A61K47/6843 ,  A61K47/6913 ,  A61K49/0008 ,  A61K51/1018 ,  C12N15/8509 ,  Y10T436/146666

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供包含PRO227，PRO233，PRO238，PRO1328，PRO4342，PRO7423，PRO10096，PRO21384，PRO353或PRO1885基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US08227661B2

公开(公告)日：2012-07-24

申请号：US12907655

申请日：2010-10-19

申请人： Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Oox

发明人： Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Oox

IPC分类号： G01N33/00 ,  A01K67/00 ,  A01K67/027

CPC分类号： A01K67/0276 ,  A01K2217/054 ,  A01K2227/105 ,  A01K2267/03 ,  A61K47/6843 ,  A61K47/6913 ,  A61K49/0008 ,  A61K51/1018 ,  C12N15/8509 ,  Y10T436/146666

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供包含PRO227，PRO233，PRO238，PRO1328，PRO4342，PRO7423，PRO10096，PRO21384，PRO353或PRO1885基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20100031378A1

公开(公告)日：2010-02-04

申请号：US12221669

申请日：2008-08-04

申请人： Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Oox

发明人： Joel A. Edwards ,  Wenhu Huang ,  Charles Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Oox

IPC分类号： G01N33/483 ,  C12Q1/68 ,  C12N5/06 ,  C07K16/18 ,  C12Q1/02 ,  A61K39/395

CPC分类号： A01K67/0276 ,  A01K2217/054 ,  A01K2227/105 ,  A01K2267/03 ,  A61K47/6843 ,  A61K47/6913 ,  A61K49/0008 ,  A61K51/1018 ,  C12N15/8509 ,  Y10T436/146666

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供包含PRO227，PRO233，PRO238，PRO1328，PRO4342，PRO7423，PRO10096，PRO21384，PRO353或PRO1885基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US20110191865A1

公开(公告)日：2011-08-04

申请号：US11457708

申请日：2009-06-03

申请人： Joel A. Edwards ,  Wenhu Huang ,  Charles A. Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Westbrook

发明人： Joel A. Edwards ,  Wenhu Huang ,  Charles A. Montgomery ,  Ni Nancy Qian ,  Zheng-Zheng Shi ,  Mary Jean Sparks ,  Peter Vogel ,  Mindy Westbrook

IPC分类号： G01N33/48 ,  A61K39/395 ,  C12Q1/02 ,  C12N5/10 ,  C12N5/071 ,  C07K16/18 ,  A61P35/00 ,  A61P25/00 ,  A61P9/00 ,  A61P3/00 ,  A61P37/02 ,  A61P25/24 ,  A61P25/22 ,  A61P25/18 ,  A61P27/02 ,  A61P27/06 ,  A61P27/12 ,  A61P3/10 ,  A61P9/10 ,  A61P9/04 ,  A61P9/12 ,  A61P29/00 ,  A61P19/02 ,  A61P19/10

CPC分类号： C07K14/47 ,  A01K2217/075

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO227, PRO233, PRO238, PRO1328, PRO4342, PRO7423, PRO10096, PRO21384, PRO353 or PRO1885 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地，本发明提供包含PRO227，PRO233，PRO238，PRO1328，PRO4342，PRO7423，PRO10096，PRO21384，PRO353或PRO1885基因中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。

公开(公告)号：US07402730B1

公开(公告)日：2008-07-22

申请号：US11347838

申请日：2006-02-03

申请人： Mary Jean Sparks ,  Wenhu Huang

发明人： Mary Jean Sparks ,  Wenhu Huang

IPC分类号： A01K67/027 ,  A01K67/00 ,  G01N33/00 ,  C12P21/00 ,  C12N15/00 ,  C12N5/00 ,  G01N33/02

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2267/0306 ,  A01K2267/0362 ,  G01N2800/044

摘要： Genetically engineered cells and animals are described that incorporate a mutated GHP1 allele. Animals that are homozygous for the mutated GHP1 allele are useful for the production of monoclonal antibodies against GHP1.

摘要翻译： 描述了基因工程细胞和动物，其包含突变的GHP1等位基因。 对于突变的GHP1等位基因纯合的动物可用于生产针对GHP1的单克隆抗体。

公开(公告)号：US08067664B2

公开(公告)日：2011-11-29

申请号：US10583466

申请日：2004-12-13

申请人： Wenhu Huang

发明人： Wenhu Huang

IPC分类号： G01N33/00 ,  C12N15/00

CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306

摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.

摘要翻译： 本发明涉及转基因动物，以及与基因功能表征相关的组合物和方法。 具体地说，本发明提供包含PRO224，PRO9783，PRO1108，PRO34000，PRO240，PRO943，hu A33，PRO230，PRO178，PRO1199，PRO4333，PRO1336，PRO19598，PRO1083，hu TRPM2或PRO1801基因中的中断的转基因小鼠。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防，改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管，内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。