公开(公告)号：US20130278929A1

公开(公告)日：2013-10-24

申请号：US13451290

申请日：2012-04-19

Applicant: Alexandre M. Bratkovski ,  R. Stanley Williams ,  Zhiyong Li

Inventor： Alexandre M. Bratkovski ,  R. Stanley Williams ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01J3/021 ,  G01N21/658

Abstract: Apparatus, methods, and hollow metal waveguides to perform surface-enhanced Raman spectroscopy are disclosed. An example apparatus includes a hollow metal waveguide to direct Raman photons from an intermediate location within a volume of the hollow metal waveguide toward a distal end of the hollow metal waveguide, and a mirror to direct incident light from a light source to the intermediate location within the volume of the hollow metal waveguide and to direct at least some of the Raman photons toward the distal end.

Abstract translation: 公开了用于执行表面增强拉曼光谱的装置，方法和中空金属波导。 示例性装置包括中空金属波导，以将拉曼光子从中空金属波导的体积内的中间位置引向中空金属波导的远端，以及反射镜，用于将来自光源的入射光引导到中间金属波导的中间位置 中空金属波导的体积并且将至少一些拉曼光子引向远端。

公开(公告)号：US08279437B2

公开(公告)日：2012-10-02

申请号：US12836097

申请日：2010-07-14

Applicant: Min Hu ,  Alexandre M. Bratkovski ,  Huel Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

Inventor： Min Hu ,  Alexandre M. Bratkovski ,  Huel Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Michael Josef Stuke ,  Michael Renne Ty Tan ,  Shih-Yuan Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/18 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/651

Abstract: An apparatus for detecting at least one species using Raman light detection includes at least one laser source for illuminating a sample containing the at least one species. The apparatus also includes a modulating element for modulating a spatial relationship between the sample and the light beams to cause relative positions of the sample and the light beams to be oscillated, in which Raman light at differing intensity levels are configured to be emitted from the at least one species based upon the different wavelengths of the light beams illuminating the sample. The apparatus also includes a Raman light detector and a post-signal processing unit configured to detect the at least one species.

Abstract translation: 用于使用拉曼光检测来检测至少一种物质的装置包括用于照亮含有至少一种物质的样品的至少一个激光源。 该装置还包括用于调制样品与光束之间的空间关系的调制元件，以使得样品和光束的相对位置发生振荡，其中以不同强度水平的拉曼光被配置为从at 基于照射样品的光束的不同波长的至少一种物质。 该装置还包括拉曼光检测器和被配置为检测至少一种物种的后信号处理单元。

公开(公告)号：US20110188035A1

公开(公告)日：2011-08-04

申请号：US12697156

申请日：2010-01-29

Applicant: Huei Pei Kuo ,  Michael J. Stuke ,  Min Hu ,  Fung Suong Ou ,  Shih-Yuan (SY) Wang ,  Alexandre M. Bratkovski ,  Wei Wu ,  Zhiyong Li

Inventor： Huei Pei Kuo ,  Michael J. Stuke ,  Min Hu ,  Fung Suong Ou ,  Shih-Yuan (SY) Wang ,  Alexandre M. Bratkovski ,  Wei Wu ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01J3/44

Abstract: A vibrating tip surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a nano-needle configured to vibrate. The apparatus includes the nano-needle with a substantially sharp tip at a free end opposite an end attached to a substrate. The tip is configured to adsorb an analyte. The apparatus further includes a vibration source configured to provide an alternating current (AC) electric field that induces a vibration of the free end and the tip of the nano-needle. Vibration of the nano-needle under the influence of the AC electric field facilitates detection of a Raman scattering signal from the analyte adsorbed on the nano-needle tip. The system further includes a synchronous detector configured to be gated cooperatively with the vibration of the nano-needle. The method includes inducing the vibration, illuminating the vibrating tip to produce a Raman signal, and detecting the Raman signal using the detector.

Abstract translation: 振动尖端表面增强拉曼光谱（SERS）装置，系统和方法采用配置为振动的纳米针。 该装置包括在与连接到基底的端相对的自由端处具有基本尖锐的尖端的纳米针。 尖端构造成吸附分析物。 该装置还包括一个被配置为提供交流（AC）电场的振动源，其引起自由端和纳米针的尖端的振动。 在AC电场的影响下，纳米针的振动有助于检测吸附在纳米针尖上的分析物的拉曼散射信号。 该系统还包括配置为与纳米针的振动协同地选通的同步检测器。 该方法包括引起振动，照亮振动尖端以产生拉曼信号，并使用检测器检测拉曼信号。

公开(公告)号：US20100091274A1

公开(公告)日：2010-04-15

申请号：US12287549

申请日：2008-10-10

Applicant: Alexandre M. Bratkovski ,  Ekaterina Viktorovna Ponizovskaya ,  Zhiyong Li

Inventor： Alexandre M. Bratkovski ,  Ekaterina Viktorovna Ponizovskaya ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/55

CPC classification number: G01N21/658

Abstract: Various embodiments of the present invention relate to plasmonic electric-field concentrators and to systems incorporating the plasmonic electric-field concentrators to perform Raman spectroscopy. In one aspect, a plasmonic electric-field concentrator comprises two or more large features, and a relatively small feature similar in shape to large features positioned adjacent to the two or more large features. The features are arranged so that when light of an appropriate wavelength is incident on the features, surface plasmon polaritons form on the outer surfaces of the features. The surface plasmon polaritons have associated electric fields extending perpendicular to the surfaces of the features. The electric fields are concentrated in the space between features forming an electric field hot spot that enhances Raman scattered light emitted from an analyte proximate to or absorbed on the features.

Abstract translation: 本发明的各种实施例涉及等离子体电场集中器以及结合等离子体激元集中器以执行拉曼光谱的系统。 一方面，等离子体电场集中器包括两个或更多个大特征，以及与形状相邻的相对较小的特征，其尺寸与两个或更多个特征邻近的大特征相似。 特征被布置成使得当适当波长的光入射到特征上时，在特征的外表面上形成表面等离子体激元。 表面等离子体激元极化子具有垂直于特征表面延伸的相关电场。 电场集中在形成电场热点的特征之间的空间中，其增强了从附近或被吸收在特征上的分析物发射的拉曼散射光。

公开(公告)号：US07391511B1

公开(公告)日：2008-06-24

申请号：US11700986

申请日：2007-01-31

Applicant: Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Zhiyong Li

Inventor： Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: A Raman signal-enhancing structure includes a substrate and a plurality of protrusions located at predetermined positions relative to a surface of the substrate. Each protrusion includes a Raman signal-enhancing material and has cross-sectional dimensions of less than about 50 nanometers. The structure also includes an edge that includes an intersection between two nonparallel surfaces of at least one protrusion. A Raman spectroscopy system includes such a Raman signal-enhancing structure, and Raman spectroscopy may be performed on an analyte using such structures and systems. A method for forming such a Raman signal-enhancing structure includes nanoimprint lithography.

Abstract translation: 拉曼信号增强结构包括基板和位于相对于基板的表面的预定位置处的多个突起。 每个突起包括拉曼信号增强材料并且具有小于约50纳米的横截面尺寸。 该结构还包括边缘，其包括至少一个突起的两个不平行表面之间的交叉点。 拉曼光谱系统包括这样的拉曼信号增强结构，并且可以使用这种结构和系统对分析物进行拉曼光谱。 形成这种拉曼信号增强结构的方法包括纳米压印光刻。

公开(公告)号：US09442071B2

公开(公告)日：2016-09-13

申请号：US14394287

申请日：2012-04-24

Applicant: Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

Inventor： Steven Barcelo ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Ansoon Kim

IPC: G01J3/44 ,  G01B11/16 ,  G01N21/00 ,  G01N33/566 ,  G01N30/96 ,  G01N21/65 ,  B82Y15/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01N2201/06113 ,  Y10S977/954

Abstract: An apparatus for performing a sensing application includes a reservoir to contain a solution, a dispenser to dispense the solution from the reservoir, and a substrate having a plurality of nano-fingers positioned to receive the dispensed solution, in which the plurality of nano-fingers are flexible, such that the plurality of nano-fingers are configurable with respect to each other. The apparatus also includes an illumination source to illuminate the received solution, an analyte introduced around the plurality of nano-fingers, and the plurality of nano-fingers, in which light is to be emitted from the analyte in response to being illuminated. The apparatus further includes a detector to detect the light emitted from the analyte.

Abstract translation: 用于执行感测应用的装置包括容纳溶液的储存器，用于从储存器分配溶液的分配器以及具有多个纳米手指的基板，该多个纳米手指定位成接收分配的溶液，其中多个纳米手指 是柔性的，使得多个纳米手指可相对于彼此配置。 所述装置还包括照亮所接收的溶液的照明源，围绕所述多个纳米手指引入的分析物和所述多个纳米手指，其中光将响应于被照亮从分析物发射。 该装置还包括检测器，用于检测从分析物发射的光。

公开(公告)号：US09080980B2

公开(公告)日：2015-07-14

申请号：US14233957

申请日：2011-07-27

Applicant: Alexandre M Bratkovski ,  Zhiyong Li

Inventor： Alexandre M Bratkovski ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65 ,  G01N21/01

CPC classification number: G01N21/658 ,  G01N21/01

Abstract: A surface enhanced Raman spectroscopy (SERS) apparatus employs a nanorod in an indentation in a surface of a substrate. The SERS apparatus includes the nanorod having a tip at a free end opposite to an end of the nanorod that is supported by the substrate indentation. The indentation has a tapered profile and supports the nanorod at a bottom of the indentation. The free end of the nanorod extends away from the indentation bottom. The SERS apparatus further includes a Raman-active material at a surface of one or both of the nanorod and the indentation. The indentation and the nanorod facilitate one or both of production and detection of a Raman scattering signal emitted by an analyte in a vicinity of the nanorod and indentation.

Abstract translation: 表面增强拉曼光谱（SERS）装置在衬底的表面中采用在压痕中的纳米棒。 SERS装置包括在由衬底压痕支撑的纳米棒的端部相对的自由端处具有尖端的纳米棒。 压痕具有锥形轮廓并且支撑在压痕底部的纳米棒。 纳米棒的自由端延伸远离压痕底部。 SERS装置还包括在纳米棒和凹陷中的一个或两个的表面处的拉曼活性材料。 压痕和纳米棒促进由纳米棒和压痕附近的分析物发射的拉曼散射信号的生成和检测中的一个或两个。

公开(公告)号：US20150103340A1

公开(公告)日：2015-04-16

申请号：US14405334

申请日：2012-07-29

Applicant: Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

Inventor： Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

IPC: G01N21/65

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/4412 ,  G01N2021/651 ,  G01N2201/06113 ,  Y10S977/902

Abstract: A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.

Abstract translation: 散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。 散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。 通过暴露在入射到保护罩上的光束可选地去除保护罩。 保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。

公开(公告)号：US08477303B2

公开(公告)日：2013-07-02

申请号：US13014688

申请日：2011-01-26

Applicant: Alexandre M Bratkovski ,  Wei Wu ,  Zhiyong Li

Inventor： Alexandre M Bratkovski ,  Wei Wu ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y20/00

Abstract: A reconfigurable surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a stimulus responsive material to move nanorods of a plurality between inactive and active configurations. The apparatus includes the plurality of nanorods and the stimulus responsive material. The system further includes a Raman signal detector. The method of reconfigurable SERS includes providing the plurality of nanorods and exposing the stimulus responsive material to a stimulus. The exposure causes a change in one or more of a size, a shape and a volume of the stimulus responsive material that moves the nanorods between the inactive and active configurations. The active configuration facilitates one or both of production and detection of a Raman scattering signal emitted by the analyte.

Abstract translation: 可重新配置的表面增强拉曼光谱（SERS）装置，系统和方法使用刺激响应材料来移动多个非活动和活动配置之间的纳米棒。 该装置包括多个纳米棒和刺激响应材料。 该系统还包括拉曼信号检测器。 可重新配置的SERS的方法包括提供多个纳米棒并将刺激响应材料暴露于刺激。 暴露导致在非活性和活动配置之间移动纳米棒的刺激响应材料的尺寸，形状和体积中的一种或多种的变化。 活性配置有利于分析物发射的拉曼散射信号的生成和检测中的一个或两个。

公开(公告)号：US08390804B2

公开(公告)日：2013-03-05

申请号：US12697136

申请日：2010-01-29

Applicant: Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

Inventor： Michael J. Stuke ,  Alexandre M. Bratkovski ,  Min Hu ,  Huei Pei Kuo ,  Jingjing Li ,  Zhiyong Li ,  Fung Suong Ou ,  Shih-Yuan (Sy) Wang ,  Wei Wu

IPC: G01J3/44

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: A surface enhanced Raman spectroscopy (SERS) apparatus, system and method employ a plurality of nanorods configured to vibrate. The apparatus includes the nanorods having tips at free ends opposite an end attached to a substrate. The tips are configured to adsorb an analyte and to vibrate at a vibration frequency. The apparatus further includes a vibration source configured to vibrate the free ends of the nanorods at the vibration frequency in a back-and-forth motion. Vibration of the nanorods is configured to facilitate detection of a Raman scattering signal emitted by the analyte adsorbed on the nanorod tips. The system further includes a synchronous detector configured to receive the Raman signal and to be gated cooperatively with the vibration of the nanorods. The method includes inducing a vibration of the nanorods, illuminating the vibrating tips to produce a Raman signal, and detecting the Raman signal using the detector.

Abstract translation: 表面增强拉曼光谱（SERS）装置，系统和方法采用配置成振动的多个纳米棒。 该装置包括纳米棒，其具有与连接到基底的端部相对的自由端处的尖端。 尖端被配置为吸附分析物并以振动频率振动。 该装置还包括一个振动源，其构造成以往复运动的振动频率使纳米棒的自由端振动。 纳米棒的振动被配置为便于检测由吸附在纳米棒尖端上的分析物发射的拉曼散射信号。 该系统还包括一个同步检测器，其被配置为接收拉曼信号并与纳米棒的振动协同地门控。 该方法包括诱导纳米棒的振动，照亮振动尖端以产生拉曼信号，以及使用检测器检测拉曼信号。