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公开(公告)号：US11304440B2
公开(公告)日：2022-04-19
申请号：US16674838
申请日：2019-11-05
Applicant: ALTRIA CLIENT SERVICES LLC
Inventor： Chengalrayan Kudithipudi , Alec J. Hayes , Marcos Fernando de Godoy Lusso , Jerry Whit Morris
Abstract: This disclosure provides tobacco plants containing a PMT RNAi and tobacco plants having a mutation in PMT, and methods of making and using such plants.
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公开(公告)号：US11299743B2
公开(公告)日：2022-04-12
申请号：US16825394
申请日：2020-03-20
Applicant: ALTRIA CLIENT SERVICES LLC
Inventor： Chengalrayan Kudithipudi , Alec J. Hayes , Robert Frank Hart, III , Yanxin Shen , Jesse Frederick , Dongmei Xu
Abstract: Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.
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公开(公告)号：US11236349B2
公开(公告)日：2022-02-01
申请号：US16589783
申请日：2019-10-01
Applicant: ALTRIA CLIENT SERVICES LLC
Inventor： Chengalrayan Kudithipudi , Yanxin Shen , Dongmei Xu , Jesse Frederick , Jaemo Yang
IPC: C12N15/82 , C07K14/415
Abstract: This disclosure provides a number of sequences involved in axillary bud growth in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences or transgenes of such sequences, and tobacco products made from tobacco leaf harvested from such plants.
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公开(公告)号：US11220695B2
公开(公告)日：2022-01-11
申请号：US16291878
申请日：2019-03-04
Applicant: Altria Client Services LLC
Inventor： Marcos Fernando de Godoy Lusso , James A Strickland , Jesse Frederick , Dongmei Xu , Chengalrayan Kudithipudi
Abstract: The present disclosure includes methods and compositions for improving leaf quality in low-alkaloid tobacco plants, e.g., by combining inducible promoters and non-coding RNAs for suppression of an ornithine decarboxylase (ODC) gene. Also provided are low alkaloid tobacco plants with normal, suppressed, or otherwise altered polyamine levels. Further provided are tobacco plants with altered total alkaloid, nicotine levels, commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
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公开(公告)号：US20200040350A1
公开(公告)日：2020-02-06
申请号：US16529365
申请日：2019-08-01
Applicant: Altria Client Services LLC
Inventor： Chengalrayan Kudithipudi , Jaemo Yang , Yanxin Shen , Dongmei Xu , Ujwala Warek , James Strickland , Jesse Frederick
IPC: C12N15/82
Abstract: The present disclosure provides the identification of promoters that are preferentially active in tobacco axillary buds. Also provided are tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing tobacco plants comprising reduced or no sucker growth.
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Patent Agency Ranking
公开(公告)号：US20190300893A1
公开(公告)日：2019-10-03
申请号：US16372833
申请日：2019-04-02
Applicant: Altria Client Services LLC
Inventor： Chengalrayan Kudithipudi , Dongmei Xu , James Strickland , Yanxin Shen
Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radical absorbance capacity (ORAC), increase phenylalanine, or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.
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公开(公告)号：US20160281100A1
公开(公告)日：2016-09-29
申请号：US14875928
申请日：2015-10-06
Applicant: ALTRIA CLIENT SERVICES LLC
Inventor： Chengalrayan Kudithipudi , Yanxin Shen , Dongmei Xu , Jesse Frederick , Jaemo Yang
CPC classification number: C12N15/8218 , C07K14/415 , C12N15/8229 , C12N15/8261 , C12N15/8295 , Y02A40/146
Abstract: This disclosure provides a number of sequences involved in axillary bud growth in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences or transgenes of such sequences, and tobacco products made from tobacco leaf harvested from such plants.
Abstract translation: 本公开提供了涉及烟草腋芽生长的多个序列，使用这些序列的方法，携带这种序列的转基因的烟草植物，以及由此类序列的转基因制成的烟草制品以及从这些植物收获的烟叶制成的烟草制品。
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公开(公告)号：US12270037B2
公开(公告)日：2025-04-08
申请号：US17766786
申请日：2020-10-09
Applicant: ALTRIA CLIENT SERVICES LLC
Inventor： Chengalrayan Kudithipudi , Rajanikanth Govindarajulu , Nazmul Bhuiyan , Raja Payyavula , Yanxin Shen , Dongmei Xu
IPC: C12N15/82 , C07K14/415 , C12N15/113
Abstract: The present disclosure provides composition and methods for improving leaf quality of low-alkaloid tobacco plants. Also provided are the identification and genetic engineering of target genes (Leaf Quality Genes) for producing tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.
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公开(公告)号：US20250051794A1
公开(公告)日：2025-02-13
申请号：US18928836
申请日：2024-10-28
Applicant: Altria Client Services LLC
Inventor： Jesse Frederick , Chengalrayan Kudithipudi , Dongmei Xu
Abstract: This disclosure provides a number of sequences involved in nitrogen utilization, methods of using such sequences, tobacco plants carrying modifications to such sequences, tobacco plants transgenic for such sequences, and tobacco products made from such plants.
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公开(公告)号：US11999961B2
公开(公告)日：2024-06-04
申请号：US17830072
申请日：2022-06-01
Applicant: Altria Client Services LLC
Inventor： Chengalrayan Kudithipudi , Dongmei Xu , James Strickland , Yanxin Shen
CPC classification number: C12N15/8243 , A01H6/823 , A24B13/00 , A24B15/10 , A24B15/245 , C12N15/8251 , C12Y402/01091
Abstract: The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), increase phenylalanine, or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.
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