公开(公告)号：US20090017040A1

公开(公告)日：2009-01-15

申请号：US12213006

申请日：2008-06-12

申请人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

发明人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/06 ,  A61P25/00 ,  G01N33/53 ,  C07H21/04

CPC分类号： A61K39/3955 ,  A61K31/5513 ,  A61K45/06 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/4711 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/52

摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD)

摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供新的方法和组合物，其包含具有特异性识别和结合来自β-淀粉样蛋白范围的特异性表位的能力的高度特异性和高效抗体。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性疾病，包括但不限于神经障碍如阿尔茨海默病（AD）

公开(公告)号：US09687447B2

公开(公告)日：2017-06-27

申请号：US13881502

申请日：2011-10-26

申请人： Pedro Reis ,  David Hickman ,  Maria Pihlgren Bosch ,  Andreas Muhs ,  Andrea Pfeifer

发明人： Pedro Reis ,  David Hickman ,  Maria Pihlgren Bosch ,  Andreas Muhs ,  Andrea Pfeifer

IPC分类号： A61K39/395 ,  A61K9/127 ,  A61K9/00 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  A61K47/48 ,  C07K16/18 ,  G01N33/68

CPC分类号： A61K9/1278 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/1271 ,  A61K39/0007 ,  A61K39/385 ,  A61K39/39 ,  A61K47/542 ,  A61K47/62 ,  A61K47/6911 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55572 ,  C07K16/18 ,  G01N33/6896 ,  Y02A50/41

摘要： The present invention relates to method for preparing liposome-based constructs comprising a peptide, particularly an antigenic peptide, of interest modified through hydrophobic moieties reconstituted in liposomes and to the antigenic constructs obtained with said method. The invention further relates to the use of said constructs for the therapeutic and diagnostic use in the treatment of diseases and disorders, which are caused by or associated with proteopathy such as Alzheimer's Disease.

公开(公告)号：US09146244B2

公开(公告)日：2015-09-29

申请号：US13272603

申请日：2011-10-13

申请人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs

发明人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs

IPC分类号： C07H21/04 ,  C07K16/18 ,  G01N33/68 ,  A61K39/395 ,  A61K39/00 ,  A61K47/48

CPC分类号： G01N33/6896 ,  A61K39/0007 ,  A61K39/3955 ,  A61K47/6911 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供包含高度特异性和高效抗体的方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白斑形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

公开(公告)号：US08124353B2

公开(公告)日：2012-02-28

申请号：US12311505

申请日：2007-10-02

申请人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

发明人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

IPC分类号： G01N33/53

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/6896

摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of j3-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列j3-淀粉样蛋白质的特异性表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

公开(公告)号：US07892544B2

公开(公告)日：2011-02-22

申请号：US11777777

申请日：2007-07-13

申请人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

发明人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/6896

摘要： The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.

摘要翻译： 本发明涉及嵌合和人源化抗体以及用于治疗和诊断用途的方法和组合物，用于治疗淀粉样变性，一类与阿尔茨海默病等淀粉样蛋白相关的病症和异常。

公开(公告)号：US20100285108A1

公开(公告)日：2010-11-11

申请号：US12661628

申请日：2010-03-18

申请人： Andrea Pfeifer ,  Andreas Muhs ,  Maria Pihlgren

发明人： Andrea Pfeifer ,  Andreas Muhs ,  Maria Pihlgren

IPC分类号： A61K9/127 ,  A61K39/00 ,  A61K39/385 ,  A61P25/28 ,  A61P37/04 ,  A61P31/18 ,  A61P25/00 ,  A61P25/16

CPC分类号： C07K14/4711 ,  A61K39/0007 ,  A61K2039/55555 ,  A61K2039/6018

摘要： The present invention is related to methods for the therapeutic use in the treatment of diseases and disorders where T-helper independent antibody responses are beneficial. In particular, the present invention relates to a method wherein these diseases and disorders above are treated in immunocompromised or autoimmune diseased animals or humans. Even more particular the present invention relates to the treatment of Alzheimer's disease in immunocompromised or autoimmune diseased animals or humans or where inflammatory reactions need to be specifically avoided.

摘要翻译： 本发明涉及治疗用于治疗T辅助者独立抗体应答有益的疾病和病症的方法。 特别地，本发明涉及一种方法，其中在免疫受损或自身免疫疾病的动物或人中治疗上述这些疾病和病症。 更具体地，本发明涉及在免疫受损或自身免疫疾病的动物或人中治疗阿尔茨海默病，或者需要特别避免炎症反应。

公开(公告)号：US07772375B2

公开(公告)日：2010-08-10

申请号：US11637213

申请日：2006-12-11

申请人： Ruth Greferath ,  David Hickman ,  Andreas Muhs ,  Andrea Pfeifer ,  Claude Nicolau

发明人： Ruth Greferath ,  David Hickman ,  Andreas Muhs ,  Andrea Pfeifer ,  Claude Nicolau

IPC分类号： C07K16/18 ,  C12N5/12 ,  A61K39/395 ,  A61K31/00

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  G01N2333/4709 ,  A61K2300/00

摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

公开(公告)号：US20090155249A1

公开(公告)日：2009-06-18

申请号：US12138372

申请日：2008-06-12

申请人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

发明人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  G01N33/53 ,  C12N15/00 ,  C12N5/06

CPC分类号： C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.

摘要翻译： 本发明涉及嵌合和人源化抗体以及用于治疗和诊断用途的方法和组合物，用于治疗淀粉样变性，一类与阿尔茨海默病等淀粉样蛋白相关的病症和异常。

公开(公告)号：US20070166311A1

公开(公告)日：2007-07-19

申请号：US11637213

申请日：2006-12-11

申请人： Ruth Greferath ,  David Hickman ,  Andreas Muhs ,  Andrea Pfeifer ,  Claude Nicolau

发明人： Ruth Greferath ,  David Hickman ,  Andreas Muhs ,  Andrea Pfeifer ,  Claude Nicolau

IPC分类号： A61K39/395 ,  C07K16/40

CPC分类号： C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  G01N2333/4709 ,  A61K2300/00

摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供新的方法和组合物，其包含具有特异性识别和结合来自β-淀粉样蛋白范围的特异性表位的能力的高度特异性和高效抗体。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

公开(公告)号：US20070040698A1

公开(公告)日：2007-02-22

申请号：US11292678

申请日：2005-12-02

申请人： Andreas Hoffmann ,  Andreas Muhs ,  Hermann Krause ,  Jurgen Ziemke ,  Klaus Puschner ,  Michael Schnatwinkel ,  Ralf Schumacher ,  Stefan Reker ,  Stefan Schumann ,  Ulrike Klasing

发明人： Andreas Hoffmann ,  Andreas Muhs ,  Hermann Krause ,  Jurgen Ziemke ,  Klaus Puschner ,  Michael Schnatwinkel ,  Ralf Schumacher ,  Stefan Reker ,  Stefan Schumann ,  Ulrike Klasing

IPC分类号： G09F9/33

CPC分类号： H01R13/7172 ,  H01R13/465 ,  H01R13/717 ,  H01R13/7175 ,  Y10T307/766

摘要： An electrical power distribution device such as a junction box or the like includes a status indicator that also serves not only to indicate the status of energization of a connector mounted in a first housing opening, but also to illuminate a translucent indicia-bearing plate mounted in second housing opening. The housing contains a chamber in which are mounted a light emitting diode that is energized simultaneously with the connector, and a light transmitting member that directs the light produced by the LED toward the second housing opening.

摘要翻译： 诸如接线盒等的电力分配装置包括状态指示器，其状态指示器也不仅用于指示安装在第一壳体开口中的连接器的通电状态，而且还用于照亮安装在第一壳体开口中的半透明标记承载板 第二个房屋开放。 壳体包括一个室，其中安装有与连接器同时通电的发光二极管，以及将由LED产生的光引导到第二壳体开口的透光构件。