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1.发明授权Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody 有权使用抗淀粉样蛋白-β抗体治疗与淀粉样蛋白-β相关病理学相关的眼部疾病的方法公开(公告)号：US09403902B2
公开(公告)日：2016-08-02
申请号：US12681696
申请日：2008-10-03
申请人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
发明人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
IPC分类号： A61K39/395 , C07K16/18 , A61K39/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/54 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention provides methods and compositions comprising highly specific and highly effective antibodies that specifically recognize and bind to specific epitopes from a range of amyloid-beta proteins. The antibodies of the present invention are particularly useful for the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system, particularly those ocular diseases associated with amyloid-beta-related pathological abnormalities/changes in the tissues of the visual system.
摘要翻译： 本发明提供包含高度特异性和高效抗体的方法和组合物，其特异性识别并结合来自淀粉样蛋白-β蛋白质范围的特异性表位。 本发明的抗体特别可用于治疗与视觉系统的组织中的病理学异常/变化相关的眼部疾病，特别是与视觉上的淀粉样蛋白-β相关的病理学异常/组织变化相关的眼部疾病 系统。
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公开(公告)号：US08796439B2
公开(公告)日：2014-08-05
申请号：US13568995
申请日：2012-08-07
申请人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
发明人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/6896
摘要： The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.
摘要翻译： 本发明涉及嵌合和人源化抗体以及用于治疗和诊断用途的方法和组合物，用于治疗淀粉样变性，一类与阿尔茨海默病等淀粉样蛋白相关的病症和异常。
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公开(公告)号：US08048420B2
公开(公告)日：2011-11-01
申请号：US12213007
申请日：2008-06-12
申请人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
发明人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： G01N33/6896 , A61K39/0007 , A61K39/3955 , A61K47/6911 , A61K2039/505 , C07K16/18 , C07K2317/76 , G01N2333/4709 , G01N2800/2821
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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4.发明申请Liposome-Based Construct Comprising a Peptide Modified Through Hydrophobic Moieties 有权包含通过疏水部分修饰的肽的基于脂质体的构建体公开(公告)号：US20130224287A1
公开(公告)日：2013-08-29
申请号：US13881502
申请日：2011-10-26
CPC分类号： A61K9/1278 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K39/0007 , A61K39/385 , A61K39/39 , A61K47/542 , A61K47/62 , A61K47/6911 , A61K2039/55555 , A61K2039/55561 , A61K2039/55572 , C07K16/18 , G01N33/6896 , Y02A50/41
摘要： The present invention relates to method for preparing liposome-based constructs comprising a peptide, particularly an antigenic peptide, of interest modified through hydrophobic moieties reconstituted in liposomes and to the antigenic constructs obtained with said method. The invention further relates to the use of said constructs for the therapeutic and diagnostic use in the treatment of diseases and disorders, which are caused by or associated with proteopathy such as Alzheimer's Disease.
摘要翻译： 本发明涉及制备基于脂质体的构建体的方法，其包含通过在脂质体中重构的疏水部分修饰的目标改性的肽，特别是抗原肽，以及用所述方法获得的抗原构建体。 本发明还涉及所述构建体在治疗和诊断中用于治疗疾病和病症的用途，所述疾病和病症由诸如阿尔茨海默氏病等蛋白病引起或与之相关。
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公开(公告)号：US20120276009A1
公开(公告)日：2012-11-01
申请号：US13500608
申请日：2011-10-07
IPC分类号： A61K39/395 , C12N15/13 , A61P25/28 , A61P25/16 , C12N5/18 , A61K49/00 , C07K4/12 , C12P21/02 , G01N33/566 , G01N21/64 , C07K16/18 , A61K31/7088
CPC分类号： C07K16/18 , A61K39/0005 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2821 , G01N2800/52
摘要： The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用于治疗由神经原纤维缠结引起或与神经原纤维缠结有关的疾病和病症的方法和组合物。 特别地，本发明涉及特异性识别和结合磷酸化病理蛋白质tau-构象异构体的抗体以及涉及治疗和诊断用于治疗包括阿尔茨海默病（AD）在内的tau蛋白病的治疗和诊断用途的所述抗体的方法和组合物。
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公开(公告)号：US20120171216A1
公开(公告)日：2012-07-05
申请号：US13272603
申请日：2011-10-13
申请人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
发明人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
IPC分类号： A61K39/395 , C12N15/13 , A61P25/28 , A61P25/00 , A61P25/16 , G01N33/566 , A61P35/00 , A61P27/02 , C12P21/02 , G01N21/64 , C12N5/16 , C07K16/18 , A61P3/10
CPC分类号： G01N33/6896 , A61K39/0007 , A61K39/3955 , A61K47/6911 , A61K2039/505 , C07K16/18 , C07K2317/76 , G01N2333/4709 , G01N2800/2821
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供了包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。
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公开(公告)号：US20090017040A1
公开(公告)日：2009-01-15
申请号：US12213006
申请日：2008-06-12
申请人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
发明人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
CPC分类号： A61K39/3955 , A61K31/5513 , A61K45/06 , A61K2039/505 , C07H21/04 , C07K14/4711 , C07K16/18 , C07K16/44 , C07K2317/34 , C07K2317/565 , C07K2317/76 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/50 , G01N2800/52
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD)
摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供新的方法和组合物，其包含具有特异性识别和结合来自β-淀粉样蛋白范围的特异性表位的能力的高度特异性和高效抗体。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性疾病，包括但不限于神经障碍如阿尔茨海默病（AD）
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公开(公告)号：US08613923B2
公开(公告)日：2013-12-24
申请号：US12213006
申请日：2008-06-12
申请人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
发明人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
IPC分类号： A61K39/395 , C07K16/18 , C12N5/20 , A61K38/18
CPC分类号： A61K39/3955 , A61K31/5513 , A61K45/06 , A61K2039/505 , C07H21/04 , C07K14/4711 , C07K16/18 , C07K16/44 , C07K2317/34 , C07K2317/565 , C07K2317/76 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/50 , G01N2800/52
摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).
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公开(公告)号：US20100291097A1
公开(公告)日：2010-11-18
申请号：US12681696
申请日：2008-10-03
申请人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
发明人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , A61P27/02 , A61P27/06
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/54 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies that specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies of the present invention are particularly useful for the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system, particularly those ocular diseases associated with amyloid-beta-related pathological abnormalities/changes in the tissues of the visual system.
摘要翻译： 本发明提供包含高度特异性和高效抗体的新型方法和组合物，其特异性识别并结合来自一系列淀粉样蛋白质的特定表位。 本发明的抗体特别可用于治疗与视觉系统的组织中的病理学异常/变化相关的眼部疾病，特别是与视觉上的淀粉样蛋白-β相关的病理学异常/组织变化相关的眼部疾病 系统。
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公开(公告)号：US20100080800A1
公开(公告)日：2010-04-01
申请号：US12460747
申请日：2009-07-23
申请人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
发明人： Andrea Pfeifer , Maria Pihlgren , Andreas Muhs , Ryan Watts
IPC分类号： A61K39/395 , C07K16/18 , C07H21/04 , C12N15/63 , C12N5/00 , A61P25/00 , G01N33/53 , C12N5/02
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/6896
摘要： The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.
摘要翻译： 本发明涉及嵌合和人源化抗体以及用于治疗和诊断用途的方法和组合物，用于治疗淀粉样变性，一类与阿尔茨海默病等淀粉样蛋白相关的病症和异常。
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