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公开(公告)号：US08128930B2
公开(公告)日：2012-03-06
申请号：US12828411
申请日：2010-07-01
申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William L. Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kristen Viola
发明人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William L. Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kristen Viola
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53
CPC分类号： G01N33/5058 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本发明的抗体还阻断ADDL与神经元的结合，ADDL的组装和tau磷酸化，并且在预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US20100239597A1
公开(公告)日：2010-09-23
申请号：US12793775
申请日：2010-06-04
申请人： Gene Kinney , William R. Strohl , Zhiqiang An
发明人： Gene Kinney , William R. Strohl , Zhiqiang An
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/5058 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本发明的抗体还阻断ADDL与神经元的结合，ADDL的组装和tau磷酸化，并且在预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US07731962B2
公开(公告)日：2010-06-08
申请号：US11581843
申请日：2006-10-17
申请人： Gene Kinney , William R. Strohl , Zhiqiang An
发明人： Gene Kinney , William R. Strohl , Zhiqiang An
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/5058 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US08889138B2
公开(公告)日：2014-11-18
申请号：US12901738
申请日：2010-10-11
申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
发明人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
IPC分类号： A61K39/395 , G01N33/50 , C07K16/18 , G01N33/68
CPC分类号： G01N33/5058 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US08383113B2
公开(公告)日：2013-02-26
申请号：US13368742
申请日：2012-02-08
申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kristen Viola
发明人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kristen Viola
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53
CPC分类号： C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/5058 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US20120171224A1
公开(公告)日：2012-07-05
申请号：US13368742
申请日：2012-02-08
申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kristen Viola
发明人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kristen Viola
IPC分类号： A61K39/395 , C12N5/0793 , G01N33/566 , C07K16/18
CPC分类号： C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/5058 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US20110159013A1
公开(公告)日：2011-06-30
申请号：US12901738
申请日：2010-10-11
申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L. Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
发明人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L. Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
IPC分类号： A61K39/395 , C07K16/18 , C12N5/0793 , G01N33/53 , A61P25/28
CPC分类号： G01N33/5058 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US08420093B2
公开(公告)日：2013-04-16
申请号：US13361143
申请日：2012-01-30
申请人： Gene Kinney , William R. Strohl , Zhiqiang An
发明人： Gene Kinney , William R. Strohl , Zhiqiang An
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US07811563B2
公开(公告)日：2010-10-12
申请号：US11577426
申请日：2005-10-21
申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
发明人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53
CPC分类号： G01N33/5058 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDL的组装和酪氨酸磷酸化，并且在用于预防和治疗与淀粉样蛋白和可溶性蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US08105593B2
公开(公告)日：2012-01-31
申请号：US12793775
申请日：2010-06-04
申请人： Gene Kinney , William R. Strohl , Zhiqiang An
发明人： Gene Kinney , William R. Strohl , Zhiqiang An
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/5058 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本发明的抗体还阻断ADDL与神经元的结合，ADDL的组装和tau磷酸化，并且在预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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