公开(公告)号：US07811563B2

公开(公告)日：2010-10-12

申请号：US11577426

申请日：2005-10-21

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDL的组装和酪氨酸磷酸化，并且在用于预防和治疗与淀粉样蛋白和可溶性蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。

公开(公告)号：US08889138B2

公开(公告)日：2014-11-18

申请号：US12901738

申请日：2010-10-11

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

IPC分类号： A61K39/395 ,  G01N33/50 ,  C07K16/18 ,  G01N33/68

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。

公开(公告)号：US20110159013A1

公开(公告)日：2011-06-30

申请号：US12901738

申请日：2010-10-11

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L. Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L. Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/0793 ,  G01N33/53 ,  A61P25/28

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。

公开(公告)号：US07780963B2

公开(公告)日：2010-08-24

申请号：US11256332

申请日：2005-10-21

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白1-42的可溶性低聚物相关的疾病的方法中是有用的。

公开(公告)号：US20080175835A1

公开(公告)日：2008-07-24

申请号：US11577426

申请日：2005-10-21

申请人： Paul Acton ,  Zhigiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L. Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

发明人： Paul Acton ,  Zhigiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L. Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

IPC分类号： A61K39/395 ,  C07K16/44 ,  G01N33/536 ,  C12N9/12 ,  G01N33/53 ,  A61P25/28

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异地识别Abeta衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDL的组装和Tauphosphorylation，并且在用于预防和治疗与淀粉样蛋白β1-42的可溶性低聚物相关的疾病的方法中是有用的。

公开(公告)号：US08128930B2

公开(公告)日：2012-03-06

申请号：US12828411

申请日：2010-07-01

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L. Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L. Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本发明的抗体还阻断ADDL与神经元的结合，ADDL的组装和tau磷酸化，并且在预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。

公开(公告)号：US20100272714A1

公开(公告)日：2010-10-28

申请号：US12828411

申请日：2010-07-01

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N5/02 ,  G01N33/53

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本发明的抗体还阻断ADDL与神经元的结合，ADDL的组装和tau磷酸化，并且在预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。

公开(公告)号：US08383113B2

公开(公告)日：2013-02-26

申请号：US13368742

申请日：2012-02-08

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53

CPC分类号： C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/5058 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。

公开(公告)号：US20120171224A1

公开(公告)日：2012-07-05

申请号：US13368742

申请日：2012-02-08

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

IPC分类号： A61K39/395 ,  C12N5/0793 ,  G01N33/566 ,  C07K16/18

CPC分类号： C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/5058 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。

公开(公告)号：US20060228349A1

公开(公告)日：2006-10-12

申请号：US11256332

申请日：2005-10-21

申请人： Paul Acton ,  Zhiqiang An ,  Andrew Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Dodson ,  Gene Kinney ,  William Klein ,  Mary Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William Strohl ,  Kirsten Viola

发明人： Paul Acton ,  Zhiqiang An ,  Andrew Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Dodson ,  Gene Kinney ,  William Klein ,  Mary Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William Strohl ,  Kirsten Viola

IPC分类号： A61K39/395 ,  C07K16/40

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β1-42.

摘要翻译： 本发明涉及差异地识别Abeta衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与β1-42淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。