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公开(公告)号：US07811563B2
公开(公告)日：2010-10-12
申请号：US11577426
申请日：2005-10-21
申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
发明人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53
CPC分类号： G01N33/5058 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDL的组装和酪氨酸磷酸化，并且在用于预防和治疗与淀粉样蛋白和可溶性蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US08889138B2
公开(公告)日：2014-11-18
申请号：US12901738
申请日：2010-10-11
申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
发明人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
IPC分类号： A61K39/395 , G01N33/50 , C07K16/18 , G01N33/68
CPC分类号： G01N33/5058 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US20110159013A1
公开(公告)日：2011-06-30
申请号：US12901738
申请日：2010-10-11
申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L. Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
发明人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L. Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
IPC分类号： A61K39/395 , C07K16/18 , C12N5/0793 , G01N33/53 , A61P25/28
CPC分类号： G01N33/5058 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。
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公开(公告)号：US07780963B2
公开(公告)日：2010-08-24
申请号：US11256332
申请日：2005-10-21
申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola
发明人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53
CPC分类号： G01N33/5058 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β1-42.
摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白1-42的可溶性低聚物相关的疾病的方法中是有用的。
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公开(公告)号：US20080175835A1
公开(公告)日：2008-07-24
申请号：US11577426
申请日：2005-10-21
申请人： Paul Acton , Zhigiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L. Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
发明人： Paul Acton , Zhigiang An , Andrew J. Bett , Robert Breese , Elizabeth Chen Dodson , Gene Kinney , William L. Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kirsten Viola , Lei Chang
IPC分类号： A61K39/395 , C07K16/44 , G01N33/536 , C12N9/12 , G01N33/53 , A61P25/28
CPC分类号： G01N33/5058 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
摘要翻译： 本发明涉及差异地识别Abeta衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDL的组装和Tauphosphorylation，并且在用于预防和治疗与淀粉样蛋白β1-42的可溶性低聚物相关的疾病的方法中是有用的。
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公开(公告)号：US20060228349A1
公开(公告)日：2006-10-12
申请号：US11256332
申请日：2005-10-21
申请人： Paul Acton , Zhiqiang An , Andrew Bett , Robert Breese , Lei Chang , Elizabeth Dodson , Gene Kinney , William Klein , Mary Lambert , Xiaoping Liang , Paul Shughrue , William Strohl , Kirsten Viola
发明人： Paul Acton , Zhiqiang An , Andrew Bett , Robert Breese , Lei Chang , Elizabeth Dodson , Gene Kinney , William Klein , Mary Lambert , Xiaoping Liang , Paul Shughrue , William Strohl , Kirsten Viola
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： G01N33/5058 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821
摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β1-42.
摘要翻译： 本发明涉及差异地识别Abeta衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与β1-42淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。
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7.发明申请Monoclonal Antibodies That Target Pathological Assemblies Of Amyloid B (Abeta) 有权靶向淀粉样蛋白B（Abeta）病理组织的单克隆抗体公开(公告)号：US20070218499A1
公开(公告)日：2007-09-20
申请号：US11571532
申请日：2005-07-05
申请人： Mary Lambert , Pauline Velasco , Lei Chang , Kirsten Viola , Sara Fernandez , Pascale Lacor , Daliya Khuon , Yuesong Gong , William Klein , Grant Krafft
发明人： Mary Lambert , Pauline Velasco , Lei Chang , Kirsten Viola , Sara Fernandez , Pascale Lacor , Daliya Khuon , Yuesong Gong , William Klein , Grant Krafft
CPC分类号： C07K16/18 , C07K2317/76 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid β (Abeta) and methods of employing those antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind to Abeta oligomers on cultured hippocampal cells. The antibodies neutralize endogenous Abeta oligomers and Abeta oligomers produced in solution.
摘要翻译： 本文公开了与淀粉样蛋白β（Abeta）的可溶性低聚物以高特异性结合的抗体以及使用这些抗体的方法。 抗体能够区分阿尔茨海默病（AD）和对照人脑提取物。 抗体鉴定AD脑切片中的内源性Aβ寡聚物，并且还结合培养的海马细胞上的Abeta寡聚物。 抗体中和溶液中产生的内源性Aβ低聚物和Abeta寡聚体。
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公开(公告)号：US20070048312A1
公开(公告)日：2007-03-01
申请号：US11496149
申请日：2006-07-31
申请人： William Klein , Grant Krafft , Mary Lambert , Kirsten Viola , Brett Chromy , Lei Chang
发明人： William Klein , Grant Krafft , Mary Lambert , Kirsten Viola , Brett Chromy , Lei Chang
IPC分类号： A61K39/395
CPC分类号： G01N33/6896 , A61K38/00 , A61K2039/505 , C07K14/4711 , C07K16/18 , G01N2333/4709 , G01N2800/2821
摘要： The invention herein comprises antibodies that bind to amyloid beta-derived diffusible ligands (ADDLs). ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes.
摘要翻译： 本发明包括结合淀粉样蛋白β衍生的扩散配体（ADDL）的抗体。 ADDL包含组装成能够激活特异性细胞过程的可溶性，球状，非纤维状，寡聚结构的淀粉样蛋白β蛋白。
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公开(公告)号：US20070213512A1
公开(公告)日：2007-09-13
申请号：US11686570
申请日：2007-03-15
申请人： Grant Krafft , William Klein , Kirsten Viola , Mary Lambert , Todd Pray , Ray Lowe
发明人： Grant Krafft , William Klein , Kirsten Viola , Mary Lambert , Todd Pray , Ray Lowe
IPC分类号： C07K14/00
CPC分类号： C07K14/4711 , A61K39/0007 , C07K16/18
摘要： The present invention provides amyloid β peptide assemblies composed of at least three amyloid β peptide subunits, wherein at least one of the amyloid β peptide subunits is an amyloid β peptide analog. The invention further relates to metal complexes of amyloid β peptide assemblies and the use of amyloid β peptide assemblies as vaccines and in the identification of agents that modulate assembly of the amyloid β peptide subunits.
摘要翻译： 本发明提供了由至少三个淀粉样蛋白β肽亚基组成的淀粉样蛋白β肽组件，其中淀粉样蛋白β肽亚基中的至少一个是淀粉样蛋白β肽类似物。 本发明还涉及淀粉样蛋白β肽组件的金属络合物和淀粉样蛋白β肽组件作为疫苗的用途，以及用于鉴定调节淀粉状蛋白β肽亚基的组装的试剂。
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